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Integrins are cell surface receptors for extracellular matrix proteins and, as such, regulate adhesive cell–matrix interactions. New findings indicate that the β4 integrin subunit can also function as a signalling effector for the activated receptor tyrosine kinase Met and enhance invasive growth independent of its adhesive role.
At least one member of the Frizzled (Fz) family of receptors, together with the downstream signalling protein Dishevelled, participates in several distinct, yet closely related signal transduction pathways. Activation of the correct signal transduction pathway is critical. Here, a new study suggests that the transmembrane protein Strabismus participates in this decision.
Myosin V is a marvellous molecular motor that delivers various cargo to specific addresses in eukaryotic cells. Recent developments are leading to a detailed molecular understanding of how this enzyme transduces the chemical energy of ATP hydrolysis into mechanical movement along actin filaments.