Browse Articles

  • News & Views |

    Intrinsic factors that regulate dormancy of disseminated tumour cells (DTCs) are predominantly unknown. Now, knockdown of MSK1 is shown to accelerate bone metastasis of luminal breast cancer cells. MSK1 acts through epigenetic mechanisms that enforce the luminal phenotype and promote steady-state maintenance of DTCs within bone.

    • Candice Alexandra Grzelak
    •  & Cyrus Michael Ghajar
  • News & Views |

    Elucidating regulation of mitochondrial mRNA translation will improve our understanding of mitochondrial function during homeostasis and disease. Ribonuclease EXD2 is now shown to be important for mitochondrial translation and oxidative phosphorylation, and its loss enhances ROS production, slows development and extends lifespan in flies.

    • Brian M. Zid
    •  & Pankaj Kapahi
  • News & Views |

    Selective autophagy is important for controlled degradation of cellular components. However, a selective autophagic degradation mechanism for ribosomes in mammals has remained unclear. A study now describes non-selective and selective ribosome degradation and a significant role for ‘bystander’ non-selective autophagy.

    • Christian Münch
    •  & Ivan Dikic
  • Article |

    Gavriilidis et al. show that MTM1, which is mutated in X-linked centronuclear myopathy, and UBQLN2 recognize misfolded desmin and vimentin and trigger their degradation to clear misfolded intermediated filaments prior to aggregate formation.

    • Christos Gavriilidis
    • , Leila Laredj
    • , Romain Solinhac
    • , Nadia Messaddeq
    • , Julien Viaud
    • , Jocelyn Laporte
    • , Izabela Sumara
    •  & Karim Hnia
  • Article |

    Gawrzak et al. show that MSK1 regulates bone metastatic dormancy of ER+ breast cancer. MSK1 affects histone modifications at luminal transcription factor promoters to prevent cell differentiation and bone homing.

    • Sylwia Gawrzak
    • , Lorenzo Rinaldi
    • , Sara Gregorio
    • , Enrique J. Arenas
    • , Fernando Salvador
    • , Jelena Urosevic
    • , Cristina Figueras-Puig
    • , Federico Rojo
    • , Ivan del Barco Barrantes
    • , Juan Miguel Cejalvo
    • , Marta Palafox
    • , Marc Guiu
    • , Antonio Berenguer-Llergo
    • , Aikaterini Symeonidi
    • , Anna Bellmunt
    • , Daniela Kalafatovic
    • , Anna Arnal-Estapé
    • , Esther Fernández
    • , Barbara Müllauer
    • , Rianne Groeneveld
    • , Konstantin Slobodnyuk
    • , Camille Stephan-Otto Attolini
    • , Cristina Saura
    • , Joaquín Arribas
    • , Javier Cortes
    • , Ana Rovira
    • , Montse Muñoz
    • , Ana Lluch
    • , Violeta Serra
    • , Joan Albanell
    • , Aleix Prat
    • , Angel R. Nebreda
    • , Salvador Aznar Benitah
    •  & Roger R. Gomis
  • Article |

    RIP3 regulates mitochondrial metabolism. Yang et al. show that RIP3 activates the pyruvate dehydrogenase complex to enhance aerobic respiration and increase mitochondrial ROS during necroptosis, and MLKL is required for RIP3 translocation to mitochondria.

    • Zhentao Yang
    • , Yan Wang
    • , Yingying Zhang
    • , Xiadi He
    • , Chuan-Qi Zhong
    • , Hengxiao Ni
    • , Xin Chen
    • , Yaoji Liang
    • , Jianfeng Wu
    • , Shimin Zhao
    • , Dawang Zhou
    •  & Jiahuai Han
  • Article |

    Chen et al. demonstrate that transient Scute activation induces asymmetric division in Drosophila intestinal stem cells, which generates enteroendocrine progenitor cells that divide once before differentiation to yield a pair of enteroendocrine cells.

    • Jun Chen
    • , Na Xu
    • , Chenhui Wang
    • , Pin Huang
    • , Huanwei Huang
    • , Zhen Jin
    • , Zhongsheng Yu
    • , Tao Cai
    • , Renjie Jiao
    •  & Rongwen Xi
  • Letter |

    Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development.

    • Vasileios I. Floros
    • , Angela Pyle
    • , Sabine Dietmann
    • , Wei Wei
    • , Walfred W. C. Tang
    • , Naoko Irie
    • , Brendan Payne
    • , Antonio Capalbo
    • , Laila Noli
    • , Jonathan Coxhead
    • , Gavin Hudson
    • , Moira Crosier
    • , Henrik Strahl
    • , Yacoub Khalaf
    • , Mitinori Saitou
    • , Dusko Ilic
    • , M. Azim Surani
    •  & Patrick F. Chinnery
  • Article |

    By analysing the exonuclease EXD2, Silva et al. find that it localizes to mitochondria, and that its loss alters metabolism by affecting mitochondrial translation and causes developmental delay and lifespan extension in flies.

    • Joana Silva
    • , Suvi Aivio
    • , Philip A. Knobel
    • , Laura J. Bailey
    • , Andreu Casali
    • , Maria Vinaixa
    • , Isabel Garcia-Cao
    • , Étienne Coyaud
    • , Alexis A. Jourdain
    • , Pablo Pérez-Ferreros
    • , Ana M. Rojas
    • , Albert Antolin-Fontes
    • , Sara Samino-Gené
    • , Brian Raught
    • , Acaimo González-Reyes
    • , Lluís Ribas de Pouplana
    • , Aidan J. Doherty
    • , Oscar Yanes
    •  & Travis H. Stracker
  • Letter |

    Ibarra-Soria et al. study cellular diversity, transcriptional signatures, lineage specification and somitogenesis on a single-cell level in E8.25 mouse embryos, and reveal the regulation of blood progenitor formation by the leukotriene pathway.

    • Ximena Ibarra-Soria
    • , Wajid Jawaid
    • , Blanca Pijuan-Sala
    • , Vasileios Ladopoulos
    • , Antonio Scialdone
    • , David J. Jörg
    • , Richard C. V. Tyser
    • , Fernando J. Calero-Nieto
    • , Carla Mulas
    • , Jennifer Nichols
    • , Ludovic Vallier
    • , Shankar Srinivas
    • , Benjamin D. Simons
    • , Berthold Göttgens
    •  & John C. Marioni
  • News & Views |

    The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.

    • Miguel Sanchez-Alvarez
    •  & Chris Bakal
  • News & Views |

    Previous work has highlighted the role of metabolic shifts in regulating the formation of memory T cells, which are generated during a primary infection to provide long-lasting immunity. A study now shows that memory T cells rely on a gluconeogenesis–glycogenolysis cycle to provide antioxidant defence and support their survival.

    • Joanna Olivas
    •  & Tiffany Horng
  • Review Article |

    Friedl and co-authors discuss how migrating cells sense and respond to tissue mechanics, and how cells in turn modify their surroundings.

    • Sjoerd van Helvert
    • , Cornelis Storm
    •  & Peter Friedl
  • Editorial |

    Nature Cell Biology supports the wide dissemination of scientific findings both prior to and following publication of primary research manuscripts.

  • News & Views |

    To overcome the finite supply of muscle stem cells available for cell therapy, a study now describes a strategy for obtaining an unlimited source of myogenic progenitors derived from human pluripotent cells. Two neuronal cell surface receptors facilitate the selection of a population with enhanced regenerative potential.

    • Andrew T. V. Ho
    •  & Helen M. Blau
  • Letter |

    Ingallina et al. show that mutant p53 is protected from degradation in response to matrix stiffness in a manner dependent on RhoA geranylgeranylation and actomyosin dynamics.

    • Eleonora Ingallina
    • , Giovanni Sorrentino
    • , Rebecca Bertolio
    • , Kamil Lisek
    • , Alessandro Zannini
    • , Luca Azzolin
    • , Luisa Ulloa Severino
    • , Denis Scaini
    • , Miguel Mano
    • , Fiamma Mantovani
    • , Antonio Rosato
    • , Silvio Bicciato
    • , Stefano Piccolo
    •  & Giannino Del Sal
  • Article |

    Hicks et al. compare human pluripotent stem cell (hPSC)-derived muscle progenitors to fetal muscle cells, identify ERBB3/NGFR+ populations with improved myogenic potential in vivo and enhance cell maturation by inhibiting TGF-β signalling during directed differentiation.

    • Michael R. Hicks
    • , Julia Hiserodt
    • , Katrina Paras
    • , Wakana Fujiwara
    • , Ascia Eskin
    • , Majib Jan
    • , Haibin Xi
    • , Courtney S. Young
    • , Denis Evseenko
    • , Stanley F. Nelson
    • , Melissa J. Spencer
    • , Ben Van Handel
    •  & April D. Pyle
  • Article |

    PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression.

    • Yiwen Bu
    • , Akihiro Yoshida
    • , Nilesh Chitnis
    • , Brian J. Altman
    • , Feven Tameire
    • , Amanda Oran
    • , Victoria Gennaro
    • , Kent E. Armeson
    • , Steven B. McMahon
    • , Gerald B. Wertheim
    • , Chi V. Dang
    • , Davide Ruggero
    • , Constantinos Koumenis
    • , Serge Y. Fuchs
    •  & J. Alan Diehl
  • Letter |

    Glycogen metabolism controls memory T cells. Ma et al. show that the metabolic gene PCK1 promotes glycogen formation, which is used in the pentose phosphate pathway, generating glutathione that is important for counteraction of ROS and thus promotion of memory T-cell maintenance, and resulting in improved antitumour immunity.

    • Ruihua Ma
    • , Tiantian Ji
    • , Huafeng Zhang
    • , Wenqian Dong
    • , Xinfeng Chen
    • , Pingwei Xu
    • , Degao Chen
    • , Xiaoyu Liang
    • , Xiaonan Yin
    • , Yuying Liu
    • , Jingwei Ma
    • , Ke Tang
    • , Yi Zhang
    • , Yue’e Peng
    • , Jinzhi Lu
    • , Yi Zhang
    • , Xiaofeng Qin
    • , Xuetao Cao
    • , Yonghong Wan
    •  & Bo Huang