Nature Biotechnology

Volume 35 Issue 8, August 2017

A subset of statistically significant correlations are extruded in three-dimensional space. Price et al. (p 747) describe the integration of whole genome sequences; clinical tests, metabolomes, proteomes, and microbiomes at three time points; and regular quantified self-measurements for 108 individuals over 9 months. They obtain thousands of cross-sectional interomic correlations, each represented by a line in the circular figure, to better understand health and disease. Image credit: Allison Kudla, John C. Earls (Institute for Systems Biology)

Volume 35 Issue 8

Editorial

Time for the data to speak

Retraction of a study claiming gene editing via an Argonaute enzyme illustrates the importance of post-publication peer review in the age of 24/7 media.

Editorial 02 Aug 2017

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News

First approval in sight for Novartis' CAR-T therapy after panel vote

Cormac Sheridan
News 01 Aug 2017
LifeArc splashes out, fuelled by Keytruda

News 01 Aug 2017
Loxo TRK inhibitor data wows oncologists

Elie Dolgin
News 01 Aug 2017
First new drug approval for AML in 15 years

Cormac Sheridan
News 01 Aug 2017
Innovation drive seizes Indian biotech

Killugudi Jayaraman
News 01 Aug 2017
First multi-gene NGS diagnostic kit approved

Mark Ratner
News 01 Aug 2017
Plant breeders test drive first open-source seed bank

Lucas Laursen
News 01 Aug 2017
Google, Novartis back Medicxi's ambitions

Melanie Senior
News 01 Aug 2017
Around the world in a month

News 01 Aug 2017

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Data Page

Drug pipeline 2Q17

Laura DeFrancesco
Data Page 01 Aug 2017

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News Feature

Engineering the animal out of animal products

Amber Dance reports on a new wave of domestication—turning cells, rather than animals, into food.

Amber Dance
News Feature 01 Aug 2017

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Bioentrepreneur

Research biotech patenting 2016

Brady Huggett
Kathryn Paisner
Bioentrepreneur 01 Aug 2017

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Correspondence

Policy implications for post-Brexit biotech

John Annaloro
Tim K Mackey
Correspondence 01 Aug 2017
What the roll out of EU data legislation means for you

Rajam Neethu
Correspondence 01 Aug 2017
Ethical lessons from a tale of two genetically modified insects

Carolyn P Neuhaus
Arthur L Caplan
Correspondence 01 Aug 2017
Rules of the road for insect gene drive research and testing

Zach Adelman
Omar Akbari
Chris Wozniak
Correspondence 01 Aug 2017

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Patents

Recent patents in synthetic biology

Patents 01 Aug 2017

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News & Views

Big data opens a window onto wellness

Longitudinal multi-omics data, clinical tests and biomarker analyses across a large cohort lay the groundwork for understanding the transition from wellness to disease.

Atul J Butte
News & Views 01 Aug 2017
Pluripotent stem cells that evade the immune radar

Human pluripotent stem cells are cloaked to evade immune rejection.

Steven C Kim
Andrew B Adams
News & Views 01 Aug 2017
Turning silver dust into electronics

Irene Jarchum
News & Views 01 Aug 2017
Research Highlights

News & Views 01 Aug 2017

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Perspective

Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.

Robert M Bowers
Nikos C Kyrpides
Tanja Woyke
Perspective Open Access 01 Aug 2017

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Review Article

Characterization of noncoding regulatory DNA in the human genome

Genome-wide mapping of regulatory elements will improve our understanding of how genetic variation in the noncoding genome affects disease phenotypes.

Ran Elkon
Reuven Agami

Collection:

The 3D genome
Review Article 01 Aug 2017

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Article

A wellness study of 108 individuals using personal, dense, dynamic data clouds

Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.

Nathan D Price
Andrew T Magis
Leroy Hood
Article 17 Jul 2017
Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy

Expansion microscopy, a technique for super-resolution imaging, is extended to clinical human tissue samples that are formalin fixed, paraffin embedded, stained and/or fresh frozen.

Yongxin Zhao
Octavian Bucur
Edward S Boyden

Collection:

Super-resolution microscopy
Article 17 Jul 2017
HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Expression of the minimally polymorphic HLA-E molecule prevents NK-cell-mediated rejection of cells lacking expression of HLA-A, B and C.

Germán G Gornalusse
Roli K Hirata
David W Russell

Collection:

Stem cells from development to the clinic
Article 15 May 2017
Long time-lapse nanoscopy with spontaneously blinking membrane probes

Super-resolution imaging of the dynamics of organelle structures in live cells is facilitated by blinking, far-red dyes.

Hideo Takakura
Yongdeng Zhang
Derek Toomre

Collection:

Super-resolution microscopy
Article 03 Jul 2017
Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS

Detection of post-translational modifications by mass spectrometry is enhanced with an analytic method for data-independent acquisition proteomics.

George Rosenberger
Yansheng Liu
Ruedi Aebersold
Article 12 Jun 2017

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Letter

Engineered Cpf1 variants with altered PAM specificities

The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering.

Linyi Gao
David B T Cox
Feng Zhang
Letter 05 Jun 2017
Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly

Rapid cloning of genes from any crop plant species (or cultivar) whose chromosomes can be flow sorted is enabled by a combination of short-read sequencing and proximity ligation.

Anupriya Kaur Thind
Thomas Wicker
Simon G Krattinger
Letter 15 May 2017

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Retraction

Retraction Note: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

Feng Gao
Xiao Z Shen
Chunyu Han
Retraction 01 Aug 2017

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Erratum

Erratum: Nature Biotechnology's academic spinouts of 2016

Aaron Bouchie
Laura DeFrancesco
Sarah Webb
Erratum 01 Aug 2017
Erratum: Making individualized drugs a reality

Huub Schellekens
Mohammed Aldosari
Enrico Mastrobattista
Erratum 01 Aug 2017
Erratum: Genome-wide target specificities of CRISPR RNA-guided programmable deaminases

Daesik Kim
Kayeong Lim
Jin-Soo Kim
Erratum 01 Aug 2017

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Careers and Recruitment

Second-quarter biotech job picture

Michael Francisco
Careers and Recruitment 01 Aug 2017
People

Careers and Recruitment 01 Aug 2017

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