Volume 34 Issue 4, April 2016

Editorial

So long to the silos

Nature Biotechnology will now publish all computational biology papers in its research section, a decision that reflects an ongoing need to break down silos surrounding mathematical, computational and basic biology.

Editorial 07 Apr 2016

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News

Exosome cancer diagnostic reaches market

Cormac Sheridan
News 07 Apr 2016
Illumina sues Oxford Nanopore

News 07 Apr 2016
Roche bets on bromodomains

Eva von Schaper
News 07 Apr 2016
DNA writers attract investors

Justin Petrone
News 07 Apr 2016
Autism DNA hub opens

News 07 Apr 2016
Biotech veteran wins Taiwan's presidential election

David Cyranoski
News 07 Apr 2016
India's budget windfall for biotech entrepreneurs

Killugudi Jayaraman
News 07 Apr 2016
Paris—the city of 'bio'-light

News 07 Apr 2016
Around the world in a month

News 07 Apr 2016

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News Feature

Will Europe toast GM wheat for gluten sufferers?

Spanish researchers are testing GM low-gliadin wheat for gluten-allergy sufferers. But stifling EU bureaucracy and adoption challenges may mean an uphill struggle to market. Lucas Laursen investigates.

Lucas Laursen
News Feature 07 Apr 2016

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Bioentrepreneur

First Rounders Podcast: Daniel Cohen

Bioentrepreneur 07 Apr 2016

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Data Page

Academic partnerships 2015

Brady Huggett
Data Page 07 Apr 2016

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Correspondence

Ignore the Delaware director-compensation cases at your peril

Doreen Lilienfeld
Brian Polovoy
Mark Kessel
Correspondence 07 Apr 2016
Compressive mapping for next-generation sequencing

Deniz Yorukoglu
Yun William Yu
Bonnie Berger
Correspondence 07 Apr 2016

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Commentary

First, design for data sharing

To upend current barriers to sharing clinical data and insights, we need a framework that not only accounts for choices made by trial participants but also qualifies researchers wishing to access and analyze the data.

John Wilbanks
Stephen H Friend
Commentary Open Access 07 Apr 2016
Accessing the accelerated approval pathway for rare disease therapeutics

Improvements must be made to the qualification process for biomarkers as primary endpoints in pivotal clinical studies of treatments for the rarest of diseases.

Emil D Kakkis
Sara Kowalcyk
Max G Bronstein
Commentary 07 Apr 2016
Preparing for the next Zika

Lessons from the US Biodefense program should inform international efforts to build a medical countermeasure enterprise for emerging infectious diseases.

Kendall Hoyt
Richard Hatchett
Commentary 07 Apr 2016

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Patents

Recent patents in epigenetic targeting

Patents 07 Apr 2016

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News & Views

Genome editing for clinical HIV isolates

An engineered recombinase removes the HIV-1 provirus from patient-derived cells and reduces infection in humanized mice.

Michelle Kim
Robert F Siliciano
News & Views 07 Apr 2016
Receptor combinations hone T-cell therapy

The safety of engineered T cells is improved through gated expression of two chimeric antigen receptors.

Thomas Blankenstein
News & Views 07 Apr 2016
Plant immunity switched from bacteria to virus

A plant immune receptor is engineered to recognize viruses rather than bacteria.

Artemis Giannakopoulou
Aleksandra Bialas
Vivianne G A A Vleeshouwers
News & Views 07 Apr 2016
Research Highlights

News & Views 07 Apr 2016

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Perspective

Quality cell therapy manufacturing by design

Yonatan Y Lipsitz
Nicholas E Timmins
Peter W Zandstra
Perspective 07 Apr 2016

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Article

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

Excision of integrated HIV proviruses derived from most HIV-1 strains is achieved with a recombinase evolved in vitro.

Janet Karpinski
Ilona Hauber
Frank Buchholz

Collection:

Antimicrobial Resistance
Article 22 Feb 2016

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Letter

Transcriptome-scale RNase-footprinting of RNA-protein complexes

Transcriptome-scale detection of RNA regions protected by nonribosomal RNA-protein complexes.

Zhe Ji
Ruisheng Song
Kevin Struhl
Letter 22 Feb 2016
An injectable nanoparticle generator enhances delivery of cancer therapeutics

A silicon-based microparticle that delivers doxorubicin nanoparticles improves the efficacy of breast cancer chemotherapy.

Rong Xu
Guodong Zhang
Haifa Shen
Letter 14 Mar 2016
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

A method called PRISM rapidly identifies drug candidates that are effective against specific cancer cell lines.

Channing Yu
Aristotle M Mannan
Todd R Golub
Letter 29 Feb 2016
Targeted gene addition in human CD34⁺ hematopoietic cells for correction of X-linked chronic granulomatous disease

Targeted genetic correction of hematopoietic stem cells is applied to X-linked chronic granulomatous disease.

Suk See De Ravin
Andreas Reik
Harry L Malech
Letter 07 Mar 2016
Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy

Inclusion of a tag in CARs facilitates cell manipulation and downstream research studies.

Lingfeng Liu
Daniel Sommermeyer
Stanley R Riddell
Letter 22 Feb 2016
One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli

Application of a systems metabolic engineering strategy enables production of poly(lactate-co-glycolate) (PLGA) and other non-natural polymers in Escherichia coli.

So Young Choi
Si Jae Park
Sang Yup Lee
Letter 07 Mar 2016

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Corrigendum

Correction: Corrigendum: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

James E Dahlman
Omar O Abudayyeh
Silvana Konermann
Corrigendum 07 Apr 2016

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Erratum

Erratum: Phosphoproteomics takes it easy

Paola Picotti
Erratum 07 Apr 2016
Erratum: Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean

Zhengkui Zhou
Yu Jiang
Zhixi Tian
Erratum 07 Apr 2016

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Careers and Recruitment

Biomedical research workforce summit makes strides in implementing change for postdocs

Experts from industry and academia have begun the process of putting the biomedical research enterprise on a more sustainable path.

Viviane Callier
Careers and Recruitment 07 Apr 2016
People

Careers and Recruitment 07 Apr 2016

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Volume 34 Issue 4, April 2016

Editorial

News

News Feature

Bioentrepreneur

Data Page

Correspondence

Commentary

Patents

News & Views

Perspective

Article

Letter

Corrigendum

Erratum

Careers and Recruitment

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