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A transgenic, cloned zebrafish expressing green fluorescent protein. Cloning zebrafish from long-term cultured cells should allow genetic targeting in these fish (see Lee et al. p. 795).
As the cost of clinical development rises, and products take longer to reach the market, the biotechnology industry may be wise to take a closer look at orphan drug indications.
The Supreme Court's decision in Festo preserves flexibility in the doctrine of equivalents, restoring some confidence in patents, but creates uncertainties of its own.