Volume 35 Issue 1, January 2017

A colored scanning electron micrograph of human intestinal bacteria that colonize the small-intestine epithelia. Magnúsdóttir et al. (p 81) present a set of 773 semi-automatically generated microbial metabolic models that are fully compatible with the human genome-scale metabolic reconstruction Recon 2. These models could be used to probe the functions of the human gut microbiota. Magnification is ×2,400 when the shortest axis is printed at 25 mm. Image credit: Dennis Kunkel Microscopy/Science Photo Library (C032/1846)

Editorial

Concerns over Cures

Provisions in the 21st Century Cures Act related to leadership at the US National Institutes of Health (NIH) may spell trouble ahead.

Editorial 10 Jan 2017

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Where are the data?

Nature Biotechnology now requires data availability statements to be supplied with research papers.

Editorial 10 Jan 2017

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News

CRISPR therapeutics push into human testing

Cormac Sheridan
News 10 Jan 2017
BMS in microbiome immuno-oncology deal

News 10 Jan 2017
Ganymed's Claudin win

News 10 Jan 2017
Obama signs 21st Century Cures Act

News 10 Jan 2017
CAR-T's forge ahead, despite Juno deaths

Laura DeFrancesco
News 10 Jan 2017
First mitochondrial DNA transfer go-ahead

News 10 Jan 2017
Pancreatic islets find a new transplant home in the omentum

Charles Schmidt
News 10 Jan 2017
Gut microbiome profiling tests propelled by customer demand

Vijay Shankar
News 10 Jan 2017
Around the world in a month

News 10 Jan 2017

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Podcast

First Rounders Podcast: Jeremy Levin

Podcast 22 Dec 2016

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News Feature

After Theranos

The implosion of blood diagnostics developer Theranos has raised the question: What is feasibly detectible in a drop of blood? Emily Waltz reports.

Emily Waltz
News Feature 10 Jan 2017

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Bioentrepreneur

Innovative academic startups 2016

Brady Huggett
Bioentrepreneur 10 Jan 2017

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Correspondence

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

Seung Hwan Lee
Giandomenico Turchiano
Jin-Soo Kim
Correspondence 28 Nov 2016
Should you profit from your genome?

Jessica L Roberts
Stacey Pereira
Amy L McGuire
Correspondence 10 Jan 2017
Will a Trump administration let sleeping cells lie?

Jonathan D Moreno
Correspondence 10 Jan 2017

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Patents

The rise of the ethical license

The Broad Institute's recent licensing of its gene editing patent portfolio demonstrates how licenses can be used to restrict controversial applications of emerging technologies while society deliberates their implications.

Christi J Guerrini
Margaret A Curnutte
Christopher T Scott
Patents 10 Jan 2017
Recent patents in metagenomics

Patents 10 Jan 2017

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News & Views

An optical probe of synaptic plasticity

An endogenous protein in the mouse brain is inactivated using a light-sensitive antibody construct.

Tal Laviv
Ryohei Yasuda
News & Views 10 Jan 2017
Mining ancient proteins for next-generation drugs

Predicting the evolutionary ancestors of a protein drug provides a strategy for optimizing its pharmaceutical properties.

Robert A Lazarus
Friedrich Scheiflinger
News & Views 10 Jan 2017
Research Highlights

News & Views 10 Jan 2017
Photosynthesis gets a boost

Irene Jarchum
News & Views 10 Jan 2017

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Brief Communication

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

Multiplexed genome editing is simplified by harnessing the ability of Cpf1 to process its own pre-crRNA.

Bernd Zetsche
Matthias Heidenreich
Feng Zhang
Brief Communication 05 Dec 2016
Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

The pharmaceutical properties of coagulation factor VIII are improved by reconstructing the protein's ancestral sequence.

Philip M Zakas
Harrison C Brown
Christopher B Doering
Brief Communication 26 Sept 2016

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Article

Optical inactivation of synaptic AMPA receptors erases fear memory

Development of an optical method to inactivate synaptic receptors in mice with temporal precision will enable a better understanding of their roles in cognition.

Kiwamu Takemoto
Hiroko Iwanari
Takuya Takahashi
Article 05 Dec 2016
Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

An approach called CREATE enables multiplex genome engineering, protein engineering and mapping of mutations in bacterial and yeast cells.

Andrew D Garst
Marcelo C Bassalo
Ryan T Gill
Article 12 Dec 2016
Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

Cardiomyocytes derived from human stem cells act as a biological pacemaker in the rat heart.

Stephanie I Protze
Jie Liu
Gordon M Keller

Collection:

Stem cells from development to the clinic
Article 12 Dec 2016

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Letter

Influence of donor age on induced pluripotent stem cells

Induced pluripotent stem cells generated from older individuals have higher levels of epigenetic and genetic abnormalities.

Valentina Lo Sardo
William Ferguson
Ali Torkamani
Letter 12 Dec 2016
MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter

Urea transporter can be used as a sensitive, contrast agent-free gene reporter for magnetic resonance imaging in cells and whole animals.

Franz Schilling
Susana Ros
Kevin M Brindle
Letter 05 Dec 2016

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Resource

Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota

A large set of microbial metabolic models (AGORA) could be applied to better understand the functions of the human gut microbiome.

Stefanía Magnúsdóttir
Almut Heinken
Ines Thiele
Resource 28 Nov 2016

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Careers and Recruitment

The impact of postdoctoral training on early careers in biomedicine

While postdocs are necessary for entry into tenure-track jobs, they do not enhance salaries in other job sectors over time.

Shulamit Kahn
Donna K Ginther
Careers and Recruitment 10 Jan 2017
People

Careers and Recruitment 10 Jan 2017

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Volume 35 Issue 1, January 2017

Editorial

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Bioentrepreneur

Correspondence

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