Volume 34 Issue 11, November 2016

Editorial

Single-cell microbiology

Microbiologists are poised to embrace heterogeneity through the use of single-cell technologies.

Focus:

Single-cell technology
Editorial 08 Nov 2016
Advertisement
Railroading at the FDA

The US Food and Drug Administration approved a muscular-dystrophy drug against the scientific advice of its own staff and advisors. Despite leadership's attempts to downplay the controversy, doubts now surround standards for accelerated approval.

Editorial 08 Nov 2016

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News

CAR-T cells forge ahead, Novartis reorganizes

Cormac Sheridan
News 08 Nov 2016
Opdivo's lung cancer aspirations dashed

News 08 Nov 2016
Hope for anti-amyloid antibodies surges, yet again

Chris Morrison
News 08 Nov 2016
Amgen's migraine antibody advances

News 08 Nov 2016
Mutanome draws Genentech deal

News 08 Nov 2016
Zika pipeline progresses

Laura DeFrancesco
News 08 Nov 2016
3D cancer cells library

News 08 Nov 2016
Sanofi and Google in type 2 diabetes smartphone tie-up

Eric Smalley
News 08 Nov 2016

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Correction

Corrections

Correction 08 Nov 2016

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Data Page

Drug pipeline: 3Q16

Laura DeFrancesco
Data Page 08 Nov 2016

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News Feature

The cancer bloodhounds

Detecting cancer by liquid biopsy is attracting a lot of money and hype. Can it deliver on its promise to transform oncology? Sarah Webb reports.

Sarah Webb

Focus:

Single-cell technology
News Feature 08 Nov 2016

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Bioentrepreneur

Venturing across the Atlantic

Is it worth your time to seek overseas investors?

Rogier W Rooswinkel
Daan S W Berbers
Sander van Deventer
Bioentrepreneur 08 Nov 2016

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Correspondence

SPLASH, a hashed identifier for mass spectra

Gert Wohlgemuth
Sajjan S Mehta
Oliver Fiehn
Correspondence 08 Nov 2016
The discombobulation of de-identification

Mark Phillips
Bartha M Knoppers
Correspondence 08 Nov 2016
Confounding factors in identification of disease-resilient individuals

David S Rosenblatt
David Watkins
Harvey L Levy
Correspondence 08 Nov 2016
Regulation of synthetic biology under the Nagoya Protocol

Bruce S Manheim
Correspondence 08 Nov 2016

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Commentary

Greener revolutions for all

To ensure global food security for all, the adoption of crop improvement technologies is no longer just an option—it is an imperative.

Richard B Flavell

Nature Outlook:

Food security
Commentary 08 Nov 2016

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Feature

Single-cell analysis at the threshold

A discussion of some of the challenges and promise of single-cell technology.

Xi Chen
J Christopher Love
Sarah A Teichmann

Focus:

Single-cell technology
Feature 08 Nov 2016

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Patents

Myriad's impact on gene patents

Three years later, the landmark Myriad decision on gene patents has led to some striking and unforeseen implications.

Mateo Aboy
Kathleen Liddell
Cristina Crespo
Patents 08 Nov 2016
Recent patents in RNA-based therapies

Patents 08 Nov 2016

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News & Views

Microcantilevers track single-cell mass

An array of microfluidic cantilevers measures the mass of single cells in a population over time and detects drug-induced changes in cell growth.

Rashid Bashir

Focus:

Single-cell technology
News & Views 08 Nov 2016
Defining cell type with chromatin profiling

Enhancer cytometry outperforms gene expression profiling in identifying hematopoietic cell subtypes.

Mikhail Spivakov
Peter Fraser
News & Views 08 Nov 2016
Research Highlights

News & Views 08 Nov 2016
High-yield chemical synthesis by reprogramming central metabolism

Altering the hardwired stoichiometry of central metabolism in yeast enables efficient synthesis of the isoprenoid β-farnesene.

Vivian Y Yu
Michelle C Y Chang
News & Views 08 Nov 2016

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Analysis

A multicenter study benchmarks software tools for label-free proteome quantification

LFQbench, a software tool to assess the quality of label-free quantitative proteomics analyses, enables developers to benchmark and improve analytic methods.

Pedro Navarro
Jörg Kuharev
Stefan Tenzer
Analysis 03 Oct 2016

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Perspective

Challenges in long-term imaging and quantification of single-cell dynamics

The experimental and computational tools that enable continuous imaging of single cells for days and weeks have advanced rapidly in recent years, and solutions to current limitations are on the horizon.

Stavroula Skylaki
Oliver Hilsenbeck
Timm Schroeder

Focus:

Single-cell technology
Perspective 08 Nov 2016

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Review Article

Revealing the vectors of cellular identity with single-cell genomics

Computational methods for analyzing single-cell data are uncovering new ways of defining cells.

Allon Wagner
Aviv Regev
Nir Yosef

Focus:

Single-cell technology
Review Article 08 Nov 2016

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Article

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate

The efficacy of cancer drugs is profiled by measuring changes in the mass of single tumor cells.

Mark M Stevens
Cecile L Maire
Scott R Manalis
Article 10 Oct 2016
Differentiation of human embryonic stem cells to HOXA⁺ hemogenic vasculature that resembles the aorta-gonad-mesonephros

Human embryonic stem cells are differentiated to cells similar to the embryonic aorta-gonad-mesonephros, which gives rise to hematopoietic stem cells.

Elizabeth S Ng
Lisa Azzola
Andrew G Elefanty
Article 17 Oct 2016
Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

The activating and repressing nucleotides of regulatory regions are identified at a genome-wide scale using tiling reporter assays.

Jason Ernst
Alexandre Melnikov
Manolis Kellis
Article 03 Oct 2016

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Resource

Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling

Proteomics, lipidomics and metabolomics of single gene deletion yeast strains sheds light on mitochondrial protein biology.

Jonathan A Stefely
Nicholas W Kwiecien
Joshua J Coon
Resource 26 Sept 2016
A proteomic atlas of the legume Medicago truncatula and its nitrogen-fixing endosymbiont Sinorhizobium meliloti

A proteomic atlas of a model legume and its rhizobial symbiont provides a resource for understanding symbiotic nitrogen fixation.

Harald Marx
Catherine E Minogue
Joshua J Coon
Resource 17 Oct 2016

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Erratum

Erratum: Defining digital medicine

Eric Elenko
Lindsay Underwood
Daphne Zohar
Erratum 08 Nov 2016

Top of page ⤴

Careers and Recruitment

Third-quarter biotech job picture

Michael Francisco
Careers and Recruitment 08 Nov 2016
People

Careers and Recruitment 08 Nov 2016

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In This Issue

In this issue

Focus:

Single-cell technology
In This Issue 08 Nov 2016

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Volume 34 Issue 11, November 2016

Editorial

News

Correction

Data Page

News Feature

Bioentrepreneur

Correspondence

Commentary

Feature

Patents

News & Views

Analysis

Perspective

Review Article

Article

Resource

Erratum

Careers and Recruitment

In This Issue

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