Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

Gao, F. et al. Cell 158, 481–491 (2014)

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

Smallwood, S.A. et al. Nat. Methods 11, 817–820 (2014)

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Xue, W. et al. Nature doi:10.1038/nature13589 (6 August 2014)

Chromatin state dynamics during blood formation

Lara-Astiaso, D. et al. Science doi:10.1126/science.1256271 (7 August 2014)

Three-dimensionally printed biological machines powered by skeletal muscle

Cvetkovic, C. et al. PNAS 111, 10125–10130 (2014)

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Prakash, T.P. et al. Nucleic Acids Res. 42, 8796–8807 (2014)