Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Inconsistency in large pharmacogenomic studies

Haibe-Kains, B. et al. Nature doi:10.1038/nature12831 (27 November 2013)

TIGRA: a targeted iterative graph routing assembler for breakpoint assembly

Chen, K. et al. Genome Res. doi:10.1101/gr.162883.113 (4 December 2013)

Digital genomic quantification of tumor-infiltrating lymphocytes

Robins, H.S. et al. Sci. Transl. Med. 214, 214ra169 (2013)

Hepatitis C virus E2 envelope glycoprotein core structure

Kong, L. et al. Science 342, 1090–1094 (2013)

Mutational and fitness landscapes of an RNA virus revealed through population sequencing

Acevedo, A. et al. Nature doi:10.1038/nature12861 (27 November 2013)