The entire metabolic pathway for producing a biofuel is confined within a yeast organelle to increase yield over the endogenous pathway split between two compartments.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering
Nature Communications Open Access 18 May 2018
-
Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways
Scientific Reports Open Access 21 September 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Farhi, M. et al. Metab. Eng. 13, 474–481 (2011).
Bayer, T.S. et al. J. Am. Chem. Soc. 131, 6508–6515 (2009).
Avalos, J.L., Fink, G.R. & Stephanopoulos, G. Nat. Biotechnol. 31, 335–341 (2013).
Atsumi, S., Hanai, T. & Liao, J.C. Nature 451, 86–89 (2008).
Brat, D., Weber, C., Lorenzen, W., Bode, H.B. & Boles, E. Biotechnol. Biofuels 5, 65 (2012).
Chen, X., Nielsen, K.F., Borodina, I., Kielland-Brandt, M.C. & Karhumaa, K. Biotechnol. Biofuels 4, 21 (2011).
Kondo, T. et al. J. Biotechnol. 159, 32–37 (2012).
Martín, D., Piulachs, M.-D., Cunillera, N., Ferrer, A. & Bellés, X. Biochim. Biophys. Acta 1773, 419–426 (2007).
Denoncin, K. & Collet, J.-F. Antioxid. Redox Signal. published online, doi:10.1089/ars.2012.4864 (2 October 2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
DeLoache, W., Dueber, J. Compartmentalizing metabolic pathways in organelles. Nat Biotechnol 31, 320–321 (2013). https://doi.org/10.1038/nbt.2549
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2549
This article is cited by
-
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering
Nature Communications (2018)
-
Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways
Scientific Reports (2017)