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| Focus | Top |
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| Clinical diagnostics is a downstream application of a significant fraction of technologies published in Nature Biotechnology. This focus provides an overview of recent progress in biomarker discovery and validation and an assessment of the scientific, business, regulatory, intellectual property, technology transfer and logistical challenges in accelerating the integration of these markers into diagnostic tests for use in guiding treatment selection and dosage. |
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| Editorials | Top |
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Focus on Diagnostics
Lost in validation p869
doi:10.1038/nbt0806-869
Abstract | Full text | PDF
(82K)
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Focus on Diagnostics
Not for the chicken-hearted p870
doi:10.1038/nbt0806-870
Abstract | Full text | PDF
(60K)
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| News | Top |
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Bundling next-generation cancer therapies for synergy pp871 - 872
Jim Kling
Published online: 03 August 2006 | doi:10.1038/nbt0806-871
Abstract | Full text | PDF
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A reprise for collaborative financing in biotech pp873 - 874
John Ransom
Published online: 03 August 2006 | doi:10.1038/nbt0806-873
Abstract | Full text | PDF
(853K)
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Tysabri back on market p874
Cormac Sheridan
Published online: 03 August 2006 | doi:10.1038/nbt0806-874
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(60K)
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Alfimeprase to succeed Genentech's alteplase? pp875 - 876
Brian Vastag
Published online: 03 August 2006 | doi:10.1038/nbt0806-875
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(300K)
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Belated approval of first recombinant protein from animal p877
Charlie Schmidt
Published online: 03 August 2006 | doi:10.1038/nbt0806-877
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(745K)
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| In Brief |
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News In Brief pp879 - 880
doi:10.1038/nbt0806-879
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(795K)
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Profile: Una Ryan p881
Charlie Schmidt
Published online: 03 August 2006 | doi:10.1038/nbt0806-881
Abstract | Full text | PDF
(253K)
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| Data Page |
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Biotech financing retrenches in Q2 p883
Stacy Lawrence
Published online: 03 August 2006 | doi:10.1038/nbt0806-883
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(238K)
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Focus on Diagnostics
Diagnostics investors think positive p884
Stacy Lawrence
doi:10.1038/nbt0806-884
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(136K)
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| News Feature |
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Focus on Diagnostics
Looking for solid ground along the Critical Path pp885 - 887
Mark Ratner
Published online: 03 August 2006 | doi:10.1038/nbt0806-885
Abstract | Full text | PDF
(470K)
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Focus on Diagnostics
Genetic profiteering pp888 - 890
Laura De Francesco
Published online: 03 August 2006 | doi:10.1038/nbt0806-888
Abstract | Full text | PDF
(964K)
| Supplementary Information |
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Focus on Diagnostics
Moving diagnostics from the bench to the bedside pp891 - 893
Jim Kling
Published online: 03 August 2006 | doi:10.1038/nbt0806-891
Abstract | Full text | PDF
(374K)
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| Bioentrepreneur | Top |
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| Building a business |
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Power dating: a guide to VC courtship pp895 - 897
Karen Boezi, Elliot Parks, Laura Shawver, Scott Salka & Chris Erlich
Published online: 23 June 2006 | doi:10.1038/bioent909
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(1,009K)
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| Opinion and Comment | Top |
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| Correspondence |
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Should we make a fuss? p899
Jan A. Witkowski
doi:10.1038/nbt0806-899a
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(343K)
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Should we make a fuss? pp899 - 900
Henry I. Miller & Gregory Conko
doi:10.1038/nbt0806-899b
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(884K)
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Export signals pp900 - 901
Péter Gál, Barbara Végh, Péter Závodszky & Ferenc Vonderviszt
doi:10.1038/nbt0806-900
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Reply to Export signals pp901 - 902
doi:10.1038/nbt0806-901
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(819K)
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Protein annotation by EBIMed pp902 - 903
Dietrich Rebholz-Schuhmann, Harald Kirsch, Miguel Arregui, Sylvain Gaudan, Mark Rynbeek & Peter Stoehr
doi:10.1038/nbt0806-902
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(610K)
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| Commentary |
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Focus on Diagnostics
Cancer biomarkers: a systems approach pp905 - 908
Lee Hartwell, David Mankoff, Amanda Paulovich, Scott Ramsey & Elizabeth Swisher
doi:10.1038/nbt0806-905
Abstract | Full text | PDF
(141K)
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Focus on Diagnostics
Translating in vivo diagnostics into clinical reality pp909 - 913
John V Frangioni
doi:10.1038/nbt0806-909
Abstract | Full text | PDF
(1,488K)
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Focus on Diagnostics
What brown cannot do for you pp914 - 916
David L Rimm
doi:10.1038/nbt0806-914
Abstract | Full text | PDF
(444K)
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Focus on Diagnostics
Three barriers to innovative diagnostics pp917 - 918
Paul R Billings
doi:10.1038/nbt0806-917
Abstract | Full text | PDF
(923K)
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Focus on Diagnostics
Partnering for better microbial diagnostics pp919 - 921
Mark D Perkins & Peter M Small
doi:10.1038/nbt0806-919
Abstract | Full text | PDF
(295K)
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Focus on Diagnostics
A change in the market—investing in diagnostics pp922 - 926
Keith Batchelder & Peter Miller
doi:10.1038/nbt0806-922
Abstract | Full text | PDF
(342K)
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Focus on Diagnostics
A regulatory perspective on in vitro diagnostics pp927 - 929
Scott Gottlieb & Janet Woodcock
doi:10.1038/nbt0806-927
Abstract | Full text | PDF
(678K)
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| Investor's Lab |
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Focus on Diagnostics
Any diamonds in the diagnostic coal? p930
Tom Jacobs
doi:10.1038/nbt0806-930
Full text | PDF
(69K)
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| Features | Top |
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Focus on Diagnostics
New-wave diagnostics pp931 - 938
Monya Baker
doi:10.1038/nbt0806-931
Abstract | Full text | PDF
(2,215K)
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| Patents |
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Focus on Diagnostics
Emerging patent issues in genomic diagnostics pp939 - 941
John H Barton
doi:10.1038/nbt0806-939
Abstract | Full text | PDF
(596K)
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Focus on Diagnostics
Shifting emphasis from pharmacogenomics to theragnostics pp942 - 946
Vural Ozdemir, Bryn Williams-Jones, Stephen J Glatt, Ming T Tsuang, James B Lohr & Christopher Reist
doi:10.1038/nbt0806-942
Abstract | Full text | PDF
(133K)
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Focus on Diagnostics
Recent patent applications in molecular diagnostics p947
doi:10.1038/nbt0806-947
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(41K)
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| News and Views | Top |
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AAV hits the genomic bull's-eye pp949 - 950
John F Engelhardt
doi:10.1038/nbt0806-949
Abstract | Full text | PDF
(220K)
See also: Research by Miller et al. |
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All in the RNA family pp951 - 952
Beverly L Davidson
doi:10.1038/nbt0806-951
Abstract | Full text | PDF
(910K)
See also: Research by McNamara et al. |
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Blueprint of an oil-eating bacterium pp952 - 953
Víctor de Lorenzo
doi:10.1038/nbt0806-952
Abstract | Full text | PDF
(704K)
See also: Research by Schneiker et al. |
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Specificity by design pp954 - 955
Carl O Pabo
doi:10.1038/nbt0806-954
Abstract | Full text | PDF
(521K)
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Transgenesis sunny-side up pp955 - 956
Helen Sang
doi:10.1038/nbt0806-955
Abstract | Full text | PDF
(760K)
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Research Highlights p957
doi:10.1038/nbt0806-957
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(211K)
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| Computational Biology | Top |
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| Primer |
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How does DNA sequence motif discovery work? pp959 - 961
Patrik D'haeseleer
doi:10.1038/nbt0806-959
Abstract | Full text | PDF
(155K)
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| Analysis |
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High-resolution computational models of genome binding events pp963 - 970
Yuan Qi, Alex Rolfe, Kenzie D MacIsaac, Georg K Gerber, Dmitry Pokholok, Julia Zeitlinger, Timothy Danford, Robin D Dowell, Ernest Fraenkel, Tommi S Jaakkola, Richard A Young & David K Gifford
Published online: 09 August 2006 | doi:10.1038/nbt1233
Abstract | Full text | PDF
(2,034K)
| Supplementary Information |
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| Research | Top |
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| Perspective |
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Focus on Diagnostics
Protein biomarker discovery and validation: the long and uncertain path to clinical utility pp971 - 983
Nader Rifai, Michael A Gillette & Steven A Carr
Published online: 09 August 2006 | doi:10.1038/nbt1235
Abstract | Full text | PDF
(384K)
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| Review |
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Focus on Diagnostics
The role of companion diagnostics in the development and use of mutation-targeted cancer therapies pp985 - 995
Nickolas Papadopoulos, Kenneth W Kinzler & Bert Vogelstein
Published online: 09 August 2006 | doi:10.1038/nbt1234
Abstract | Full text | PDF
(1,341K)
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| Articles |
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Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis pp997 - 1004
Susanne Schneiker, Vítor AP Martins dos Santos, Daniela Bartels, Thomas Bekel, Martina Brecht, Jens Buhrmester, Tatyana N Chernikova, Renata Denaro, Manuel Ferrer, Christoph Gertler, Alexander Goesmann, Olga V Golyshina, Filip Kaminski, Amit N Khachane, Siegmund Lang, Burkhard Linke, Alice C McHardy, Folker Meyer, Taras Nechitaylo, Alfred Pühler, Daniela Regenhardt, Oliver Rupp, Julia S Sabirova, Werner Selbitschka, Michail M Yakimov, Kenneth N Timmis, Frank-Jörg Vorhölter, Stefan Weidner, Olaf Kaiser & Peter N Golyshin
Published online: 30 July 2006 | doi:10.1038/nbt1232
Abstract | Full text | PDF
(546K)
| Supplementary Information
See also: News and Views by de Lorenzo |
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Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras pp1005 - 1015
James O McNamara II, Eran R Andrechek, Yong Wang, Kristi D Viles, Rachel E Rempel, Eli Gilboa, Bruce A Sullenger & Paloma H Giangrande
Published online: 25 June 2006 | doi:10.1038/nbt1223
Abstract | Full text | PDF
(680K)
| Supplementary Information
See also: News and Views by Davidson |
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| Letters |
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Stem cell–derived erythroid cells mediate long-term systemic protein delivery pp1017 - 1021
Alex H Chang, Matthias T Stephan & Michel Sadelain
Published online: 16 July 2006 | doi:10.1038/nbt1227
Abstract | Full text | PDF
(216K)
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Gene targeting in vivo by adeno-associated virus vectors pp1022 - 1026
Daniel G Miller, Pei-Rong Wang, Lisa M Petek, Roli K Hirata, Mark S Sands & David W Russell
Published online: 30 July 2006 | doi:10.1038/nbt1231
Abstract | Full text | PDF
(357K)
| Supplementary Information
See also: News and Views by Engelhardt |
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Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes pp1027 - 1032
Brian F Pfleger, Douglas J Pitera, Christina D Smolke & Jay D Keasling
Published online: 16 July 2006 | doi:10.1038/nbt1226
Abstract | Full text | PDF
(406K)
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| Corrigenda | Top |
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Corrigendum: ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe p1033
Akihisa Matsuyama, Ritsuko Arai, Yoko Yashiroda, Atsuko Shirai, Ayako Kamata, Shigeko Sekido, Yumiko Kobayashi, Atsushi Hashimoto, Makiko Hamamoto, Yasushi Hiraoka, Sueharu Horinouchi & Minoru Yoshida
doi:10.1038/nbt0806-1033a
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(67K)
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Corrigendum: Drugging the PI3 kinome p1033
Paul Workman, Paul A Clarke, Sandrine Guillard & Florence I Raynaud
doi:10.1038/nbt0806-1033b
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(67K)
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Corrigendum: Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR p1033
Cynthia H Collins, Jared R Leadbetter & Frances H Arnold
doi:10.1038/nbt0806-1033c
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(67K)
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Corrigendum: Insights into US public biotech sector using patenting trends p1033
Saurabh Aggarwal, Vinay Gupta & Sharmistha Bagchi-Sen
doi:10.1038/nbt0806-1033d
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(67K)
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Corrigendum: Design of a genome-wide siRNA library using an artificial neural network p1033
Dieter Huesken, Joerg Lange, Craig Mickanin, Jan Weiler, Fred Asselbergs, Justin Warner, Brian Meloon, Sharon Engel, Avi Rosenberg, Dalia Cohen, Mark Labow, Mischa Reinhardt, François Natt & Jonathan Hall
doi:10.1038/nbt0806-1033e
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(67K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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The science-business tango pp1035 - 1036
Mari Paul
doi:10.1038/nbt0806-1035
Abstract | Full text | PDF
(407K)
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| People |
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People p1038
doi:10.1038/nbt0806-1038
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(328K)
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