Nature Biotechnology

Volume 23 Issue 3, March 2005

Transverse section of a hind leg muscle of a 6-month-old mouse showing GFP gene expression following delivery by an adeno-associated virus 8 vector (tibia and fibula bones and muscle cell nuclei are stained red). A comparative study shows that this vector enables efficient system-wide gene delivery to muscle tissues. (Wang et al.p 321).

Volume 23 Issue 3

Editorial

A dose of reality for rational therapies

Editorial 01 Mar 2005

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News

Maturing biotechs turn to pharma's markets

The ability of biotech companies to efficiently use financial and commercial resources reflects their maturity.

Mark Ratner
News 01 Mar 2005
Synthetic biology offers alternative pathways to natural products

Industrial applications of synthetic biology as not as closeby as the media buzz makes us believe.

Stephan Herrera
News 01 Mar 2005
Cost-effectiveness data on biologics needed

Reimbursement agencies are increasingly likely to require some economic data to back the claims on the superior value of biotech drugs compared to traditional ones.

Cormac Sheridan
Alla Katsnelson
News 01 Mar 2005
Biotech consulting, investing by NIH scientists curbed

A new rule preventing NIH scientists from any outside employment by private organizations may not have such a negative effect on the biotech industry.

Jeffrey L. Fox
News 01 Mar 2005
Japanese giants renew interest in industrial biotech

Japanese corporations in seemingly unrelated areas such as automobile or electronics sector, are now investing in areas of life science such as industrial biotechnology that could contribute to applications enhancing their existing products.

Doug Sipp
News 01 Mar 2005

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News in Brief

News In Brief

News in Brief 01 Mar 2005

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News

Profile: Patrick Moore

Ex-Greenpeace activist turned biotech supporter believes that auditing the performance of biotech products is the only way to convince people of their value.

Stephan Herrera
News 01 Mar 2005

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Data Page

Agbio keeps on growing

Stacy Lawrence
Data Page 01 Mar 2005

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News Feature

Clone on the range: What animal biotech is bringing to the table

Biotech animals don't have the market value of biotech drugs and potential controversies loom large, but genetic screening technologies are already finding a market, and both cloned and transgenic animals may soon be on the menu. Alan Dove reports.

Alan W Dove
News Feature 01 Mar 2005

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Correspondence

Vaccines—why the US government must act

Henry I Miller
Correspondence 01 Mar 2005
Tomato transgene structure and silencing

Rick A Sanders
William Hiatt
Correspondence 01 Mar 2005

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Commentary

Serum proteomics profiling—a young technology begins to mature

Kevin R Coombes
Jeffrey S Morris
Keith A Baggerly
Commentary 01 Mar 2005

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Investors Lab

Bugs or drugs, tortoises or hares?

Tom Jacobs
Investors Lab 01 Mar 2005

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Film Review

Fahrenheit agbiotech

Thomas J Hoban
Film Review 01 Mar 2005

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Feature

In biomarkers we trust?

The 'omics revolution offers plenty of decision-making tools. It's knowing how to use them that's key.

Monya Baker
Feature 01 Mar 2005

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News & Views

Breaking the barriers to global gene delivery

Efficient gene delivery to muscles has been achieved with adeno-associated virus 8.

Matthew D Weitzman
Patricia A Thistlethwaite
News & Views 01 Mar 2005
Plug-and-play with RNA

Ligand-responsive riboregulators enable extracellular control of post-transcriptional gene expression.

Farren J Isaacs
James J Collins
News & Views 01 Mar 2005
Interaction maps for kinase inhibitors

The specificity of kinase inhibitors can be rapidly determined with a new in vitro competition assay.

James D Griffin
News & Views 01 Mar 2005
Adding diversity to plant transformation

Alternatives to Agrobacterium may circumvent patents on plant transformation technologies.

Mary-Dell Chilton
News & Views 01 Mar 2005
Research Highlights

News & Views 01 Mar 2005

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Perspective

Looking and listening to light: the evolution of whole-body photonic imaging

Vasilis Ntziachristos
Jorge Ripoll
Ralph Weissleder
Perspective 04 Mar 2005

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Article

Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

Zhong Wang
Tong Zhu
Xiao Xiao
Article 27 Feb 2005
A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A Fabian
William H Biggs III
David J Lockhart
Article 13 Feb 2005

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Letter

Programmable ligand-controlled riboregulators of eukaryotic gene expression

Travis S Bayer
Christina D Smolke
Letter 20 Feb 2005
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity

René Michael Hoet
Edward H Cohen
Robert Charles Ladner
Letter 20 Feb 2005
Directed evolution of human T-cell receptors with picomolar affinities by phage display

Yi Li
Ruth Moysey
Jonathan M Boulter
Letter 20 Feb 2005
Evolutionary optimization of fluorescent proteins for intracellular FRET

Annalee W Nguyen
Patrick S Daugherty
Letter 06 Feb 2005
Microfabricated arrays of femtoliter chambers allow single molecule enzymology

Yannick Rondelez
Guillaume Tresset
Hiroyuki Noji
Letter 20 Feb 2005

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Erratum

Erratum: International patent law—boon or bane of biotech?

Paroma Basu
Erratum 01 Mar 2005
Erratum: Poorer nations turn to publicly developed GM crops

Joel I Cohen
Erratum 01 Mar 2005

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Patents

Erythropoietin in the UK: a setback for gene patents?

A decision to invalidate the patent for Amgen's blockbuster is ominous for future gene patents.

R Stephen Crespi
Patents 01 Mar 2005
Patents

Patents 01 Mar 2005

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New on the Market

Proteomics and mass spectrometry

New on the Market 01 Mar 2005

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Commentary

Toward data standards for proteomics

Veerasamy Ravichandran
Ram D Sriram
Commentary 01 Mar 2005

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Analysis

Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

Diego di Bernardo
Michael J Thompson
James J Collins
Analysis 04 Mar 2005

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Careers and Recruitment

Conflict resolution in the biotech industry

An ever-changing and growing industry creates greater potential for conflict within organizations.

Mary Yaroshevsky-Glanville
Careers and Recruitment 01 Mar 2005

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People

People

People 01 Mar 2005

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