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| Editorial | Top |
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A dose of reality for rational therapies p267
doi:10.1038/nbt0305-267
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(68K)
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| News | Top |
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Maturing biotechs turn to pharma's markets p269
Mark Ratner
doi:10.1038/nbt0305-269
Abstract | Full text | PDF
(95K)
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Synthetic biology offers alternative pathways to natural products pp270 - 271
Stephan Herrera
doi:10.1038/nbt0305-270
Abstract | Full text | PDF
(204K)
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Cost-effectiveness data on biologics needed pp272 - 273
Cormac Sheridan
& Alla Katsnelson
doi:10.1038/nbt0305-272
Abstract | Full text | PDF
(155K)
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Biotech consulting, investing by NIH scientists curbed p274
Jeffrey L. Fox
doi:10.1038/nbt0305-274
Abstract | Full text | PDF
(156K)
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Japanese giants renew interest in industrial biotech pp275 - 276
Doug Sipp
doi:10.1038/nbt0305-275
Abstract | Full text | PDF
(101K)
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| In Brief |
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News In Brief pp277 - 279
doi:10.1038/nbt0305-277
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(222K)
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Profile: Patrick Moore p280
Stephan Herrera
doi:10.1038/nbt0305-280
Abstract | Full text | PDF
(104K)
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| Data Page |
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Agbio keeps on growing p281
Stacy Lawrence
doi:10.1038/nbt0305-281
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(108K)
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| News Feature |
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Clone on the range: What animal biotech is bringing to the table pp283 - 285
Alan W Dove
doi:10.1038/nbt0305-283
Abstract | Full text | PDF
(182K)
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| Opinion and Comment | Top |
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| Correspondence |
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Vaccines—why the US government must act p287
Henry I Miller
doi:10.1038/nbt0305-287a
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(55K)
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Tomato transgene structure and silencing pp287 - 289
Rick A Sanders
& William Hiatt
doi:10.1038/nbt0305-287b
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(103K)
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| Commentary |
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Serum proteomics profiling—a young technology begins to mature pp291 - 292
Kevin R Coombes, Jeffrey S Morris, Jianhua Hu, Sarah R Edmonson
& Keith A Baggerly
doi:10.1038/nbt0305-291
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(138K)
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| Investor's Lab |
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Bugs or drugs, tortoises or hares? p293
Tom Jacobs
doi:10.1038/nbt0305-293
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(54K)
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| Film Review |
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Fahrenheit agbiotech p295
Reviewed by: Thomas J Hoban
doi:10.1038/nbt0305-295
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(97K)
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| Feature | Top |
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In biomarkers we trust? pp297 - 304
Monya Baker
doi:10.1038/nbt0305-297
Abstract | Full text | PDF
(369K)
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| News and Views | Top |
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Breaking the barriers to global gene delivery pp305 - 306
Matthew D Weitzman
& Patricia A Thistlethwaite
doi:10.1038/nbt0305-305
Abstract | Full text | PDF
(119K)
See also: Research by Wang et al. |
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Plug-and-play with RNA pp306 - 307
Farren J Isaacs
& James J Collins
doi:10.1038/nbt0305-306
Abstract | Full text | PDF
(119K)
See also: Research by Bayer & Smolke |
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Interaction maps for kinase inhibitors pp308 - 309
James D Griffin
doi:10.1038/nbt0305-308
Abstract | Full text | PDF
(137K)
See also: Research by Fabian et al. |
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Adding diversity to plant transformation pp309 - 310
Mary-Dell Chilton
doi:10.1038/nbt0305-309
Abstract | Full text | PDF
(127K)
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Research Highlights p311
doi:10.1038/nbt0305-311
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(102K)
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| Research | Top |
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| Perspective |
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Looking and listening to light: the evolution of whole-body photonic imaging pp313 - 320
Vasilis Ntziachristos, Jorge Ripoll, Lihong V Wang
& Ralph Weissleder
Published online: 04 March 2005 | doi:10.1038/nbt1074
Abstract | Full text | PDF
(857K)
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| Articles |
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Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart pp321 - 328
Zhong Wang, Tong Zhu, Chunping Qiao, Liqiao Zhou, Bing Wang, Jian Zhang, Chunlian Chen, Juan Li
& Xiao Xiao
Published online: 27 February 2005 | doi:10.1038/nbt1073
Abstract | Full text | PDF
(587K)
| Supplementary Information
See also: News and Views by Weitzman & Thistlethwaite |
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A small molecule−kinase interaction map for clinical kinase inhibitors pp329 - 336
Miles A Fabian, William H Biggs III, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar
& David J Lockhart
Published online: 13 February 2005 | doi:10.1038/nbt1068
Abstract | Full text | PDF
(430K)
| Supplementary Information
See also: News and Views by Griffin |
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| Letters |
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Programmable ligand-controlled riboregulators of eukaryotic gene expression pp337 - 343
Travis S Bayer
& Christina D Smolke
Published online: 20 February 2005 | doi:10.1038/nbt1069
Abstract | Full text | PDF
(314K)
| Supplementary Information
See also: News and Views by Isaacs & Collins |
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Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity pp344 - 348
René Michael Hoet, Edward H Cohen, Rachel Baribault Kent, Kristin Rookey, Sonia Schoonbroodt, Shannon Hogan, Louise Rem, Nicolas Frans, Marc Daukandt, Henk Pieters, Rob van Hegelsom, Nicole Coolen-van Neer, Horacio G Nastri, Isaac J Rondon, Jennifer A Leeds, Simon E Hufton, Lili Huang, Irina Kashin, Mary Devlin, Guannan Kuang, Mieke Steukers, Malini Viswanathan, Andrew E Nixon, Daniel J Sexton, Hennie R Hoogenboom
& Robert Charles Ladner
Published online: 20 February 2005 | doi:10.1038/nbt1067
Abstract | Full text | PDF
(191K)
| Supplementary Information |
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Directed evolution of human T-cell receptors with picomolar affinities by phage display pp349 - 354
Yi Li, Ruth Moysey, Peter E Molloy, Anne-Lise Vuidepot, Tara Mahon, Emma Baston, Steven Dunn, Nathaniel Liddy, Jansen Jacob, Bent K Jakobsen
& Jonathan M Boulter
Published online: 20 February 2005 | doi:10.1038/nbt1070
Abstract | Full text | PDF
(232K)
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Evolutionary optimization of fluorescent proteins for intracellular FRET pp355 - 360
Annalee W Nguyen
& Patrick S Daugherty
Published online: 06 February 2005 | doi:10.1038/nbt1066
Abstract | Full text | PDF
(265K)
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Microfabricated arrays of femtoliter chambers allow single molecule enzymology pp361 - 365
Yannick Rondelez, Guillaume Tresset, Kazuhito V Tabata, Hideyuki Arata, Hiroyuki Fujita, Shoji Takeuchi
& Hiroyuki Noji
Published online: 20 February 2005 | doi:10.1038/nbt1072
Abstract | Full text | PDF
(432K)
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| Errata |
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Erratum: International patent law—boon or bane of biotech? p366
Paroma Basu
doi:10.1038/nbt0305-366a
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(28K)
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Erratum: Poorer nations turn to publicly developed GM crops p366
Joel I Cohen
doi:10.1038/nbt0305-366b
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(28K)
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| Resources | Top |
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| Patents |
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Erythropoietin in the UK: a setback for gene patents? pp367 - 368
R Stephen Crespi
doi:10.1038/nbt0305-367
Abstract | Full text | PDF
(71K)
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Patents p369
doi:10.1038/nbt0305-369
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(36K)
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| New on the Market |
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Proteomics and mass spectrometry p371
doi:10.1038/nbt0305-371
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(176K)
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| Computational Biology | Top |
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| Commentary |
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Toward data standards for proteomics pp373 - 376
Veerasamy Ravichandran
& Ram D Sriram
doi:10.1038/nbt0305-373
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(162K)
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| Analysis |
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Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks pp377 - 383
Diego di Bernardo, Michael J Thompson, Timothy S Gardner, Sarah E Chobot, Erin L Eastwood, Andrew P Wojtovich, Sean J Elliott, Scott E Schaus
& James J Collins
Published online: 04 March 2005 | doi:10.1038/nbt1075
Abstract | Full text | PDF
(567K)
| Supplementary Information |
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| Bioentrepreneur | Top |
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| Bioenews |
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Spanish wishful thinking towards biotech p385
Cormac Sheridan
Published online: 10 February 2005 | doi:10.1038/bioent847
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(169K)
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| Building a business |
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Building a strategy for maximizing intellectual property value pp387 - 389
William A Barrett
Published online: 25 January 2005 | doi:10.1038/bioent842
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(210K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Conflict resolution in the biotech industry pp391 - 392
Mary Yaroshevsky-Glanville
doi:10.1038/nbt0305-391
Abstract | Full text | PDF
(44K)
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| People |
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People p394
doi:10.1038/nbt0305-394
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(77K)
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