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| Editorial | Top |
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Out in the open p153
doi:10.1038/nbt0205-153
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(67K)
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| News | Top |
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Antiinfective biotechs face partnering gap pp155 - 156
Cormac Sheridan
doi:10.1038/nbt0205-155
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(218K)
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Stock options could no longer be the carrot p157
Stacy Lawrence
doi:10.1038/nbt0205-157
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(68K)
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Indian Bt gene monoculture, potential time bomb p158
K.S. Jayaraman, Jeffrey L. Fox, Hepeng Jia
& Claudia Orellana
doi:10.1038/nbt0205-158
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(127K)
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China steps towards international M&A p159
Hepeng Jia
& Sabine Louët
doi:10.1038/nbt0205-159
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(79K)
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| In Brief |
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News In Brief pp161 - 162
doi:10.1038/nbt0205-161
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(136K)
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Profile: Margaret Atwood p163
Sabine Louët
doi:10.1038/nbt0205-163
Abstract | Full text | PDF
(69K)
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| Data Page |
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A banner biotech year in 2004 p164
Stacy Lawrence
doi:10.1038/nbt0205-164
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(88K)
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| News Feature |
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Struggling to see the forest through the trees pp165 - 167
Stephan Herrera
doi:10.1038/nbt0205-165
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(396K)
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| Opinion and Comment | Top |
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| Correspondence |
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Knowledge sharing and 'genomic' healthcare pp169 - 170
Ireena Dutta, Philippa C Brice
& Susan Wallace
doi:10.1038/nbt0205-169
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(98K)
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Pharmacrops and bioterror p170
Suzanne Wuerthele
doi:10.1038/nbt0205-170
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(56K)
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| Commentary |
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Cat and mouse in regulating genetic 'enhancement' pp171 - 172
Henry Miller
doi:10.1038/nbt0205-171
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(231K)
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| Investor's Lab |
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Great company, bad stock p173
Tom Jacobs
doi:10.1038/nbt0205-173
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(55K)
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| Feature | Top |
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Chasing biotech, state by state—winners and losers pp175 - 179
Ken Howard Wilan
doi:10.1038/nbt0205-175
Abstract | Full text | PDF
(486K)
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| News and Views | Top |
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Dicing with siRNA pp181 - 182
Bryan R.G. Williams
doi:10.1038/nbt0205-181
Abstract | Full text | PDF
(109K)
See also: Research by Kim et al. | Research by Siolas et al. |
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A window on the dynamics of biological switches pp183 - 184
Michael Bittner
doi:10.1038/nbt0205-183
Abstract | Full text | PDF
(123K)
See also: Research by Cleary et al. |
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A new school for screening pp184 - 186
Harren Jhoti
doi:10.1038/nbt0205-184
Abstract | Full text | PDF
(189K)
See also: Research by Card et al. |
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Energy well spent on a prokaryotic genome pp186 - 187
Brian McNeil
& Linda Harvey
doi:10.1038/nbt0205-186
Abstract | Full text | PDF
(156K)
See also: Research by Prust et al. |
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Shortening the treatment of tuberculosis pp187 - 188
Denis A Mitchison
doi:10.1038/nbt0205-187
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(119K)
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Research Highlights p189
doi:10.1038/nbt0205-189
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(85K)
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| Research | Top |
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| Perspective |
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Integrating cell-level kinetic modeling into the design of engineered protein therapeutics pp191 - 194
Balaji M Rao, Douglas A Lauffenburger
& K Dane Wittrup
Published online: 04 February 2005 | doi:10.1038/nbt1064
Abstract | Full text | PDF
(156K)
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| Articles |
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Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans pp195 - 200
Christina Prust, Marc Hoffmeister, Heiko Liesegang, Arnim Wiezer, Wolfgang Florian Fricke, Armin Ehrenreich, Gerhard Gottschalk
& Uwe Deppenmeier
Published online: 23 January 2005 | doi:10.1038/nbt1062
Abstract | Full text | PDF
(313K)
| Supplementary Information
See also: News and Views by McNeil & Harvey |
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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design pp201 - 207
Graeme L Card, Landy Blasdel, Bruce P England, Chao Zhang, Yoshihisa Suzuki, Sam Gillette, Daniel Fong, Prabha N Ibrahim, Dean R Artis, Gideon Bollag, Michael V Milburn, Sung-Hou Kim, Joseph Schlessinger
& Kam Y J Zhang
Published online: 30 January 2005 | doi:10.1038/nbt1059
PDB code 1Y2B | 1Y2C | 1Y2D | 1Y2E | 1Y2H | 1Y2J | 1Y2K
Abstract | Full text | PDF
(400K)
| Supplementary Information
See also: News and Views by Jhoti |
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| Letters |
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Rescue and propagation of fully retargeted oncolytic measles viruses pp209 - 214
Takafumi Nakamura, Kah-Whye Peng, Mary Harvey, Suzanne Greiner, Ian A J Lorimer, Charles D James
& Stephen J Russell
Published online: 30 January 2005 | doi:10.1038/nbt1060
Abstract | Full text | PDF
(1,109K)
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Specification of motoneurons from human embryonic stem cells pp215 - 221
Xue-Jun Li, Zhong-Wei Du, Ewa D Zarnowska, Matthew Pankratz, Lauren O Hansen, Robert A Pearce
& Su-Chun Zhang
Published online: 30 January 2005 | doi:10.1038/nbt1063
Abstract | Full text | PDF
(730K)
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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy pp222 - 226
Dong-Ho Kim, Mark A Behlke, Scott D Rose, Mi-Sook Chang, Sangdun Choi
& John J Rossi
Published online: 26 December 2004 | doi:10.1038/nbt1051
Abstract | Full text | PDF
(206K)
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See also: News and Views by Williams |
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Synthetic shRNAs as potent RNAi triggers pp227 - 231
Despina Siolas, Cara Lerner, Julja Burchard, Wei Ge, Peter S Linsley, Patrick J Paddison, Gregory J Hannon
& Michele A Cleary
Published online: 26 December 2004 | doi:10.1038/nbt1052
Abstract | Full text | PDF
(343K)
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See also: News and Views by Williams |
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Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay pp232 - 237
Michael D Cleary, Christopher D Meiering, Eric Jan, Rebecca Guymon
& John C Boothroyd
Published online: 30 January 2005 | doi:10.1038/nbt1061
Abstract | Full text | PDF
(267K)
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See also: News and Views by Bittner |
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Functional annotation and network reconstruction through cross-platform integration of microarray data pp238 - 243
Xianghong Jasmine Zhou, Ming-Chih J Kao, Haiyan Huang, Angela Wong, Juan Nunez-Iglesias, Michael Primig, Oscar M Aparicio, Caleb E Finch, Todd E Morgan
& Wing Hung Wong
Published online: 16 January 2005 | doi:10.1038/nbt1058
Abstract | Full text | PDF
(307K)
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| Resources | Top |
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| Patents |
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The coming US patent opposition pp245 - 247
Ted Apple
doi:10.1038/nbt0205-245
Abstract | Full text | PDF
(77K)
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Patents p248
doi:10.1038/nbt0205-248
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(36K)
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| People |
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People p249
doi:10.1038/nbt0205-249
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(69K)
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| New on the Market |
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Microarrays p251
doi:10.1038/nbt0205-251
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(141K)
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Reagents & enzymes p251
doi:10.1038/nbt0205-251b
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(141K)
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| Computational Biology | Top |
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| Analysis |
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Detection of parallel functional modules by comparative analysis of genome sequences pp253 - 260
Huiying Li, Matteo Pellegrini
& David Eisenberg
Published online: 04 February 2005 | doi:10.1038/nbt1065
Abstract | Full text | PDF
(608K)
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| Bioentrepreneur | Top |
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| Bioenews |
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Survey reveals US university licensing up, startup formation down pp261 - 262
Aaron Bouchie
Published online: 13 January 2005 | doi:10.1038/bioent843
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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| Building a business |
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The importance of angels in starting a US biotech venture pp263 - 264
Jeffrey Sohl
Published online: 20 December 2004 | doi:10.1038/bioent839
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
PDF
(78K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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The best preparation for a scientist job search p265
Grace H W Wong
doi:10.1038/nbt0205-265
Abstract | Full text | PDF
(54K)
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