Nature Biotechnology
22, 1579 - 1582 (2004)
Published online: 21 November 2004; | doi:10.1038/nbt1038
Lack of interferon response in animals to naked siRNAsJeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche
& Mark E DavisSupplementary Fig. 1 (pdf 160K) RNase digestion of poly(I:C) and siRNA. Supplementary Fig. 2 (pdf 96K) Synthetic siRNA does not alter mouse CBC or liver enzyme levels. Supplementary Fig. 3 (pdf 224K) Degradation kinetics of synthetic siRNA in mouse serum. Supplementary Fig. 4 (pdf 128K) Sequence-specific target down-regulation by siRNA in RAW-264.7 cells. Supplementary Fig. 5 (pdf 96K) Synthetic siRNA accomplishes sequence-specific RNAi of an exogenous target in mice. Supplementary Fig. 6 (pdf 96K) Lack of IL-12 and IFN-a induction by siRNA in C57BL/6 mice.
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