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Nature Biotechnology  22, 1579 - 1582 (2004)
Published online: 21 November 2004; | doi:10.1038/nbt1038

Lack of interferon response in animals to naked siRNAs

Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche & Mark E Davis

Supplementary Fig. 1 (pdf 160K)
RNase digestion of poly(I:C) and siRNA.

Supplementary Fig. 2 (pdf 96K)
Synthetic siRNA does not alter mouse CBC or liver enzyme levels.

Supplementary Fig. 3 (pdf 224K)
Degradation kinetics of synthetic siRNA in mouse serum.

Supplementary Fig. 4 (pdf 128K)
Sequence-specific target down-regulation by siRNA in RAW-264.7 cells.

Supplementary Fig. 5 (pdf 96K)
Synthetic siRNA accomplishes sequence-specific RNAi of an exogenous target in mice.

Supplementary Fig. 6 (pdf 96K)
Lack of IL-12 and IFN-a induction by siRNA in C57BL/6 mice.


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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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