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Nature Biotechnology 20, 908–913 (1 September 2002) | doi:10.1038/nbt725

Rational cytokine design for increased lifetime and enhanced potency using pH-activated |[ldquo]|histidine switching|[rdquo]|

Casim A. Sarkar , Ky Lowenhaupt , Thomas Horan , Thomas C. Boone , Bruce Tidor & Douglas A. Lauffenburger