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Single-cell nanobody-tethered transposition followed by sequencing (scNTT-seq) is a new assay that measures the genome-wide presence of multiple histone modifications and protein–DNA binding sites at single-cell resolution. scNTT-seq generates high-resolution multimodal maps of chromatin states with high accuracy and sensitivity.
Nanobody–Tn5 transposase fusion proteins enable detection of two histone marks and open chromatin regions at the same time, with single-cell resolution.
A pilot program for synthetic biology education via a scalable distributed network model of distance-based laboratory learning can be accessible globally across disciplines and backgrounds.
Recent trial failures have called into question the central role of α-synuclein in Parkinson’s disease pathology. Although many continue to target α-synuclein aggregates in the brain, others are paying attention to the endolysosomal pathway, mitochondria and even glucose metabolism.
Immunomodulatory drug treats psoriasis by a new mechanism: the selective deactivation of TYK2 through its catalytically defective domain, the pseudokinase.