News & Views in 2010

An imaging study begins to define the parameters that control the biodistribution of nanoparticles after pulmonary delivery.

The sterile insect technique offers an alternative to the refuge strategy for managing resistance to Bt toxins.

Two approaches for selecting oligonucleotides from complex mixtures improve the fidelity and scalability of DNA synthesis.

Synthesis and screening of a small library of antibody fragments yields promising hits.

Deep sequencing provides a first view of the RNA structures in a eukaryotic transcriptome.

Cultured cambial meristematic cells could enable large-scale production of certain natural products.

Two comparative studies from the International Human Epigenome Project find high concordance between different methods for measuring genomic methylation.

A mass-spectrometry approach for identifying downstream events in cancer signaling pathways may help to tailor therapies to individual patients.

A noninvasive imaging method for predicting how human embryos will develop may improve the success and safety of in vitro fertilization.

Dynamic mass redistribution assays measure the complexity of G protein–coupled receptor signaling.

A long intergenic noncoding RNA may promote metastatic progression by coordinating the activity of histone-modifying enzymes.

The identification of broadly neutralizing monoclonal antibodies against HIV-1 may aid efforts to design a vaccine.

The MicroArray Quality Control (MAQC) consortium has evaluated methods for making clinically useful predictions from large-scale gene expression data.

A new method generates genome-scale modified bacteria with unprecedented ease.

The recent identification of human CD141⁺ dendritic cells as a counterpart of mouse CD8⁺ dendritic cells may be useful in developing vaccines and immunotherapies.

Transplantation of human hematopoietic stem cells engineered to lack the viral coreceptor CCR5 confers resistance to HIV infection in mice.

The complete set of tools needed to synthesize a functional genome and transplant it into a mycoplasma cell opens up the possibility of mixing and matching natural and synthetic DNA to make genomes with new capabilities.

Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.

Comprehensive phenotypic screening of knockout mice highlights the pleiotropic functions of secreted and transmembrane proteins.