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Covalent links formed between methylation enzymes and a 5-azacytidine base incorporated into cellular RNA allow target enrichment and single base-pair resolution modification mapping.
Bacteria expressing a plant siRNA-binding protein produce potent, specific and nonimmunogenic siRNAs capable of knocking down target genes in mammalian cells.
Integrating metabolomics and computational modeling provides a method to identify allosteric enzyme-metabolite interactions, which have been inaccessible to systematic mapping.