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Genome sequences of nine species of citrus, including oranges, pummelos and mandarins, reveal pathways of domestication and provide resources for breeding.
Hematopoietic differentiation of human pluripotent stem cells is directed to either the definitive or primitive program, a step toward the generation of hematopoietic stem cells.
Repurposing a DNA sequencing instrument for high-throughput analysis of RNA-protein interactions enables detailed analysis of sequence-function relationships.
By incorporating unnatural amino acids into proteins, Elliott et al. label, image and identify proteins in specific cells in a developing fly under physiological conditions.
Mice engineered to express the entire human variable immunoglobulin region enable rapid isolation of high-affinity antibodies specific for antigens of interest.
Haplotyping of human genomes is improved by augmenting experimental dilution-based haplotyping with statistical analyses, a strategy known until now only as 'Moleculo.'
Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody heavy and light chains with orthogonal interfaces.