Mining antibodies with droplet microfluidics

Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level

Latest Research

  • Review Article |

    As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.

    • Joost van Haasteren
    • , Jie Li
    • , Olivia J. Scheideler
    • , Niren Murthy
    •  & David V. Schaffer
  • Article |

    Microscopy datasets are processed orders-of-magnitude faster with improved algorithms and deep learning.

    • Min Guo
    • , Yue Li
    • , Yijun Su
    • , Talley Lambert
    • , Damian Dalle Nogare
    • , Mark W. Moyle
    • , Leighton H. Duncan
    • , Richard Ikegami
    • , Anthony Santella
    • , Ivan Rey-Suarez
    • , Daniel Green
    • , Anastasia Beiriger
    • , Jiji Chen
    • , Harshad Vishwasrao
    • , Sundar Ganesan
    • , Victoria Prince
    • , Jennifer C. Waters
    • , Christina M. Annunziata
    • , Markus Hafner
    • , William A. Mohler
    • , Ajay B. Chitnis
    • , Arpita Upadhyaya
    • , Ted B. Usdin
    • , Zhirong Bao
    • , Daniel Colón-Ramos
    • , Patrick La Riviere
    • , Huafeng Liu
    • , Yicong Wu
    •  & Hari Shroff
  • Article |

    Transient p53 inhibition and induced cell-cycle progression increase clonal engraftment and homology-directed repair in hematopoietic stem cells.

    • Samuele Ferrari
    • , Aurelien Jacob
    • , Stefano Beretta
    • , Giulia Unali
    • , Luisa Albano
    • , Valentina Vavassori
    • , Davide Cittaro
    • , Dejan Lazarevic
    • , Chiara Brombin
    • , Federica Cugnata
    • , Anna Kajaste-Rudnitski
    • , Ivan Merelli
    • , Pietro Genovese
    •  & Luigi Naldini

News & Comment

  • Feature |

    Investment and funding has continued to flow into biotech, unlike most business sectors. But with healthcare and hospital budgets increasingly under pressure, do belt-tightening and consolidation lie ahead? Melanie Senior investigates, with additional reporting by Riku Lähteenmäki.

    • Melanie Senior
  • Editorial |

    A slew of national COVID-19 exposure apps have failed because of poor public engagement and acceptance. Apps from the workplace may offer a partial solution if privacy can be guaranteed.

  • News Feature |

    The University of Washington’s Institute for Protein Design has become a hub to galvanize de novo protein engineering, citizen science and much more since its founding in 2012.

    • Caroline Seydel
  • Correspondence |

    • Alexandra M. Amen
    • , Kerrie W. Barry
    • , John M. Boyle
    • , Cara E. Brook
    • , Seunga Choo
    • , L. T. Cornmesser
    • , David J. Dilworth
    • , Jennifer A. Doudna
    • , Alexander J. Ehrenberg
    • , Indro Fedrigo
    • , Skyler E. Friedline
    • , Thomas G. W. Graham
    • , Ralph Green
    • , Jennifer R. Hamilton
    • , Ariana Hirsh
    • , Megan L. Hochstrasser
    • , Dirk Hockemeyer
    • , Netravathi Krishnappa
    • , Azra Lari
    • , Hanqin Li
    • , Enrique Lin-Shiao
    • , Tianlin Lu
    • , Elijah F. Lyons
    • , Kevin G. Mark
    • , Lisa Argento Martell
    • , A. Raquel O. Martins
    • , Shana L. McDevitt
    • , Patrick S. Mitchell
    • , Erica A. Moehle
    • , Christine Naca
    • , Divya Nandakumar
    • , Elizabeth O’Brien
    • , Derek J. Pappas
    • , Kathleen Pestal
    • , Diana L. Quach
    • , Benjamin E. Rubin
    • , Rohan Sachdeva
    • , Elizabeth C. Stahl
    • , Abdullah Muhammad Syed
    • , I-Li Tan
    • , Amy L. Tollner
    • , Connor A. Tsuchida
    • , C. Kimberly Tsui
    • , Timothy K. Turkalo
    • , Fyodor D. Urnov
    • , M. Bryan Warf
    • , Oscar N. Whitney
    •  & Lea B. Witkowsky
  • Correspondence |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    •  & Mary Wu

Naturejobs.com

Nature events Directory