The energy source that drives vesicle fusion with a target organelle in vivo has been unclear. It emerges that proteins that tether fusing structures together also decrease the energy needed for the final fusion step. See Letter p.634
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Spang, A. Bulky tether proteins aid membrane fusion. Nature 551, 576–577 (2017). https://doi.org/10.1038/nature24754
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DOI: https://doi.org/10.1038/nature24754