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Structural biology

Hypoxia response becomes crystal clear

Nature volume 524, pages 298–299 (2015)Cite this article

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The crystal structures of two proteins that respond to reduced tissue oxygen levels — hypoxia-inducible factors — provide insight into their function and reveal sites for rational drug design. See Article p.303

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Figure 1: The HIF-α–ARNT heterodimer off and on DNA.

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Authors and Affiliations

  1. Departments of Biochemistry and Biophysics, Ronen Marmorstein is in the Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.,

    Ronen Marmorstein

  2. M. Celeste Simon is in the Abramson Family Cancer Research Institute, Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.,

    M. Celeste Simon

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  1. Ronen Marmorstein
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  2. M. Celeste Simon
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Correspondence to Ronen Marmorstein or M. Celeste Simon.

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Marmorstein, R., Simon, M. Hypoxia response becomes crystal clear. Nature 524, 298–299 (2015). https://doi.org/10.1038/nature14641

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