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Origins of life

RNA made in its own mirror image

Nature volume 515, pages 347–348 (2014)Cite this article

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An RNA enzyme has been generated that can assemble a mirror-image version of itself. The finding helps to answer a long-standing conundrum about how RNA molecules could have proliferated on prebiotic Earth. See Letter p.440

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Figure 1: Possible mechanism for RNA replication on prebiotic Earth.

References

  1. Sczepanski, J. T. & Joyce, G. F. Nature 515, 440–442 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Gilbert, W. Nature 319, 618 (1986).

    Article  ADS  Google Scholar 

  3. Joyce, G. F. et al. Nature 310, 602–604 (1984).

    Article  ADS  CAS  Google Scholar 

  4. Ellington, A. D. & Szostak, J. W. Nature 346, 818–822 (1990).

    Article  ADS  CAS  Google Scholar 

  5. Tuerk, C. & Gold, L. Science 249, 505–510 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Robertson, D. L. & Joyce, G. F. Nature 344, 467–468 (1990).

    Article  ADS  CAS  Google Scholar 

  7. Bartel, D. P. & Szostak, J. W. Science 261, 1411–1418 (1993).

    Article  ADS  CAS  Google Scholar 

  8. Joyce, G. F. Angew. Chem. Int. Edn 46, 6420–6436 (2007).

    Article  CAS  Google Scholar 

  9. Attwater, J., Wochner, A. & Holliger, P. Nature Chem. 5, 1011–1018 (2013).

    Article  ADS  CAS  Google Scholar 

  10. Ashley, G. W. J. Am. Chem. Soc. 114, 9731–9736 (1992).

    Article  CAS  Google Scholar 

  11. Eulberg, D. & Klussmann, S. ChemBioChem 4, 979–983 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Sandip A. Shelke and Joseph A. Piccirilli are in the Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.,

    Sandip A. Shelke & Joseph A. Piccirilli

  2. J.A.P. is also in the Department of Chemistry, University of Chicago.,

    Joseph A. Piccirilli

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  1. Sandip A. Shelke
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  2. Joseph A. Piccirilli
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Correspondence to Joseph A. Piccirilli.

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Shelke, S., Piccirilli, J. RNA made in its own mirror image. Nature 515, 347–348 (2014). https://doi.org/10.1038/nature13935

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