Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Molecular biology

Antibiotic re-frames decoding

Nature volume 503, pages 478–479 (2013)Cite this article

Subjects

Ketolide antibiotics have been found to induce a ribosomal frameshift — a change in the way that RNA is translated — in bacteria. This promotes the expression of a gene for antibiotic resistance, and may have broader implications.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Antibiotic-induced frameshifting.

References

  1. Gupta, P., Kannan, K., Mankin, A. S. & Vázquez-Laslop, N. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2013.10.013 (2013).

  2. Horinouchi, S. & Weisblum, B. Proc. Natl Acad. Sci. USA 77, 7079–7083 (1980).

    Article  ADS  CAS  Google Scholar 

  3. Shivakumar, A. G. et al. Proc. Natl Acad. Sci. USA 77, 3903–3907 (1980).

    Article  ADS  CAS  Google Scholar 

  4. Vázquez-Laslop, N. et al. Mol. Cell 30, 190–202 (2008).

    Article  Google Scholar 

  5. Craigen, W. J. & Caskey, C. T. Nature 322, 273–275 (1986).

    Article  ADS  CAS  Google Scholar 

  6. Matsufuji, S. et al. Cell 80, 51–60 (1995).

    Article  CAS  Google Scholar 

  7. Ingolia, N. T. et al. Science 324, 218–223 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Ivanov, I. P. et al. Nucleic Acids Res. 38, 353–359 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. John F. Atkins and Pavel V. Baranov are in the School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.,

    John F. Atkins & Pavel V. Baranov

  2. J.F.A. is also in the Department of Human Genetics, University of Utah, Salt Lake City, USA.,

    John F. Atkins

Authors
  1. John F. Atkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pavel V. Baranov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to John F. Atkins or Pavel V. Baranov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atkins, J., Baranov, P. Antibiotic re-frames decoding. Nature 503, 478–479 (2013). https://doi.org/10.1038/503478a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/503478a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing