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Ageing

Sorting out the sirtuins

Nature volume 483, pages 166–167 (2012)Cite this article

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Debates over the role of sirtuin proteins in ageing are maturing into functional assessments of the individual proteins. It seems that overexpression of a specific sirtuin can extend lifespan in male mice. See Letter p.218

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Figure 1: Potential mechanisms of action of SIRT6 on longevity.

Notes

  1. *This article and the paper3 under discussion were published online on 22 February 2012.

References

  1. Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570–2580 (1999).

    Article  CAS  Google Scholar 

  2. Finkel, T., Deng, C.-X. & Mostoslavsky, R. Nature 460, 587–590 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Kanfi, Y. et al. Nature 483, 218–221 (2012).

    Article  ADS  CAS  Google Scholar 

  4. Weindruch, R. & Sohal, R. S. N. Engl. J. Med. 337, 986–994 (1997).

    Article  CAS  Google Scholar 

  5. Bartke, A. Phil. Trans. R. Soc. Lond. B 366, 28–34 (2011).

    Article  CAS  Google Scholar 

  6. Ladiges, W. et al. Aging Cell 8, 346–352 (2009).

    Article  CAS  Google Scholar 

  7. Xiao, C. et al. J. Biol. Chem. 285, 36776–36784 (2010).

    Article  CAS  Google Scholar 

  8. Guevara-Aguirre, J. et al. Sci. Transl. Med. 3, 70ra13 (2011).

    Article  Google Scholar 

  9. Muzumdar, R. et al. Aging Cell 7, 438–440 (2008).

    Article  CAS  Google Scholar 

  10. Mao, Z. et al. Science 332, 1443–1446 (2011).

    Article  ADS  CAS  Google Scholar 

  11. Kawahara, T. L. A. et al. Cell 136, 62–74 (2009).

    Article  CAS  Google Scholar 

  12. Zhong, L. et al. Cell 140, 280–293 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. David B. Lombard and Richard A. Miller are in the Department of Pathology and the Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48100-2200, USA.,

    David B. Lombard & Richard A. Miller

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  1. David B. Lombard
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  2. Richard A. Miller
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Correspondence to David B. Lombard or Richard A. Miller.

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Lombard, D., Miller, R. Sorting out the sirtuins. Nature 483, 166–167 (2012). https://doi.org/10.1038/nature10950

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