Table of contents
Volume 448 Number 7152 pp387-510
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Editorials
Nuclear test p387
Japan's response to an earthquake highlights both the promise and the pitfalls of nuclear power at a critical time for its future.
doi:10.1038/448387a
Storm brewing p387
It's the season of discord at US National Oceanic and Atmospheric Administration.
doi:10.1038/448387b
California dreaming p388
Universities should draw the line at certain types of support from the drug industry.
doi:10.1038/448388a
News
Quake shuts world's largest nuclear plant p392
No one died as a result of Japan's latest nuclear incident and environmental damage seem have been mostly avoided. But is this testimony to successful plant design or a warning of impending disaster?
David Cyranoski
doi:10.1038/448392a
Darfur lake is a 'mirage' p394
Geologists dismiss claims for ancient water source.
Declan Butler
doi:10.1038/448394a
California campuses resist industry restrictions p394
Universities cling to links with drug firms.
Erika Check
doi:10.1038/448394b
Sidelines p396
doi:10.1038/448396a
Carbon sinks threatened by increasing ozone p396
Pollutant poisons plants and hampers photosynthesis.
Michael Hopkin
doi:10.1038/448396b
Diamonds 'melted' inside an onion p396
Crystals flicker under extreme conditions.
Philip Ball
doi:10.1038/448396c
Memory seen in the making p397
Synapses caught in the act of remembering.
Kerri Smith
doi:10.1038/448397a
Libyan ordeal ends: medics freed p398
Plane takes medical workers to a pardon in Bulgaria.
Declan Butler
doi:10.1038/448398a
Stem-cell researcher's move attracts funding p398
Part-time post could mean gains for California.
Erika Check
doi:10.1038/448398b
Business
The pain game p400
The safety problems that brought down Vioxx have tainted a whole class of drugs. Meredith Wadman examines their chances of a comeback.
doi:10.1038/448400a
In brief p401
doi:10.1038/448401a
Market watch p401
Quirin Schiermeier
doi:10.1038/448401b
News Features
Conservation: Mark of respect p402
A project that gives Congolese pygmies new ways to tell logging companies about the trees that are important to them, and their own radio station to discuss community issues, is really putting their interests on the map, says Michael Hopkin.
doi:10.1038/448402a
Science in comedy: Mmm... pi p404
Part of The Simpsons' greatness is a willingness to find the humour in absolutely everything — including science. Executive producer Al Jean, the show's head writer and a Harvard mathematics graduate, talks to Nature about how to get a laugh out of Euler's formula.
doi:10.1038/448404a
See also: Editor's summary
Research policy: The map man p406
Alan Krensky has been put in charge of a controversial new office responsible for charting the progress of the NIH Roadmap for Medical Research. Meredith Wadman catches up with him in his first few days on the job.
doi:10.1038/448406a
Correspondence
Nobel laureates know what they're talking about p408
Burton Richter
doi:10.1038/448408a
Nobel: politicians need the insights scientists can give p408
Henry Kelly
doi:10.1038/448408b
How a naturalist found safe colours for soldiers p408
James T. Costa
doi:10.1038/448408c
See also: Editor's summary
Post-publication review could aid skills and quality p408
Todd A. Gibson
doi:10.1038/448408d
Correction p408
doi:10.1038/448408e
Commentary
Driving a wedge into the Amazon p409
Things are heating up in the Amazon as the burning season begins. In Brazil, a 30-year-old study of forest fragments is itself threatened by farming, logging and hunting, say William Laurance and Regina Luizão.
doi:10.1038/448409a
See also: Editor's summary
Books and Arts
A man of peace p411
One scientist's journey from the Manhattan Project to the Nobel Peace Prize.
Malcolm Dando reviews Joseph Rotblat: Visionary for Peace and War and Peace: The Life and Work of Sir Joseph Rotblat
doi:10.1038/448411a
Too much information p412
Ann Blair reviews Glut: Mastering Information Through the Ages by Alex Wright
doi:10.1038/448412a
Introducing the extremophiles p413
Sean Nee reviews The Third Domain: The Untold Story of Archaea and the Future of Biotechnology by Tim Friend
doi:10.1038/448413a
Science in culture: Mind tricks p414
Cognitive scientists take a lesson from magicians.
Susana Martinez-Conde & Stephen L. Macknik
doi:10.1038/448414a
News and Views
Biochemistry: Uncharted route for antibiotics p415
In their battle for survival, soil microorganisms produce a vast arsenal of toxic molecules. One such toxin contains a unique sequence of atoms, and its biosynthesis includes some unexpected steps.
John P. Quinn
doi:10.1038/448415a
Immunology: Narcissistic helpers p416
T helper-17 cells, which are involved in immune responses, arise from a pool of precursor cells. It emerges that their differentiation is partly mediated by the IL-21 protein, which originates from the helper cells themselves.
Matthew T. Palmer & Casey T. Weaver
doi:10.1038/448416a
50 & 100 Years Ago p417
doi:10.1038/448417a
Astrobiology: Photosynthesis in watercolours p418
The spectrum of stellar radiation available to an organism is altered by the atmosphere and water on the planet it inhabits. Study of this relationship can outline the limits to photosynthesis.
John Raven
doi:10.1038/448418a
Mathematics: Some assembly needed p419
Origami, the ancient Japanese art of paper folding, is mathematically deeper than it looks. Delving into its complexities allows the construction of elaborate and useful structures from simple, flat templates.
Ian Stewart
doi:10.1038/448419a
See also: Editor's summary
Developmental biology: A ten per cent solution p420
In early embryos, a concentration gradient of the Bicoid protein affects pattern formation. Studies of living embryos reveal a surprising level of accuracy in the Bicoid gradient. But is it accurate enough?
John Reinitz
doi:10.1038/448420a
Inflammatory disease: Assault on the guardian p421
In multiple sclerosis, the immune system attacks 'self' tissues. Ten years after the discovery of one target of this autoimmunity, work with mice identifies it as a guardian protein produced in response to inflammation.
Richard M. Ransohoff
doi:10.1038/448421a
See also: Editor's summary
Quantum computing: Powered by symmetry p422
Forces determine how particles move and behave. But so can symmetry, and exchange symmetry can be used to control the interactions of ultracold atoms. This could be a big step towards practical quantum computation.
Johannes Hecker Denschlag
doi:10.1038/448422a
See also: Editor's summary
Immunology: Sensing the enemy within p423
Damaged or foreign DNA stimulates immune responses by inducing the production of interferon proteins. New evidence indicates that this response is mediated by a cytosolic DNA sensor known as DAI.
Hongbo Chi & Richard A. Flavell
doi:10.1038/448423a
See also: Editor's summary
Obituary: Horst Tobias Witt (1922–2007) p425
Seminal research on photosynthesis.
Wolfgang Junge & A. William Rutherford
doi:10.1038/448425a
Review
Unravelling the pathogenesis of inflammatory bowel disease p427
R. J. Xavier & D. K. Podolsky
doi:10.1038/nature06005
First paragraph | Full Text | PDF (4,533K)
See also: Editor's summary
Articles
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum p435
Hidde L. Ploegh
doi:10.1038/nature06004
First paragraph | Full Text | PDF (1,843K)
See also: Editor's summary
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer p439
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas
doi:10.1038/nature05933
Abstract | Full Text | PDF (1,310K) | Supplementary information
See also: Editor's summary
Non-transcriptional control of DNA replication by c-Myc p445
David Dominguez-Sola, Carol Y. Ying, Carla Grandori, Luca Ruggiero, Brenden Chen, Muyang Li, Denise A. Galloway, Wei Gu, Jean Gautier & Riccardo Dalla-Favera
doi:10.1038/nature05953
Abstract | Full Text | PDF (991K) | Supplementary information
See also: Editor's summary
Letters
Controlled exchange interaction between pairs of neutral atoms in an optical lattice p452
Marco Anderlini, Patricia J. Lee, Benjamin L. Brown, Jennifer Sebby-Strabley, William D. Phillips & J. V. Porto
doi:10.1038/nature06011
First paragraph | Full Text | PDF (555K)
See also: Editor's summary | News and Views by Denschlag
Preparation and characterization of graphene oxide paper p457
Dmitriy A. Dikin, Sasha Stankovich, Eric J. Zimney, Richard D. Piner, Geoffrey H. B. Dommett, Guennadi Evmenenko, SonBinh T. Nguyen & Rodney S. Ruoff
doi:10.1038/nature06016
First paragraph | Full Text | PDF (1,969K) | Supplementary information
See also: Editor's summary
Detection of human influence on twentieth-century precipitation trends p461
Xuebin Zhang, Francis W. Zwiers, Gabriele C. Hegerl, F. Hugo Lambert, Nathan P. Gillett, Susan Solomon, Peter A. Stott & Toru Nozawa
doi:10.1038/nature06025
First paragraph | Full Text | PDF (464K) | Supplementary information
See also: Editor's summary
Variation in styles of rifting in the Gulf of California p466
Daniel Lizarralde, Gary J. Axen, Hillary E. Brown, John M. Fletcher, Antonio González-Fernández, Alistair J. Harding, W. Steven Holbrook, Graham M. Kent, Pedro Paramo, Fiona Sutherland & Paul J. Umhoefer
doi:10.1038/nature06035
First paragraph | Full Text | PDF (804K) | Supplementary information
See also: Editor's summary
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma p470
Miriam F. Moffatt, Michael Kabesch, Liming Liang, Anna L. Dixon, David Strachan, Simon Heath, Martin Depner, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Burkard Simma, Thomas Frischer, Saffron A. G. Willis-Owen, Kenny C. C. Wong, Thomas Illig, Christian Vogelberg, Stephan K. Weiland, Erika von Mutius, Gonçalo R. Abecasis, Martin Farrall, Ivo G. Gut, G. Mark Lathrop & William O. C. Cookson
doi:10.1038/nature06014
First paragraph | Full Text | PDF (556K) | Supplementary information
See also: Editor's summary
Protective and therapeutic role for 
B-crystallin in autoimmune demyelination p474
Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman
doi:10.1038/nature05935
First paragraph | Full Text | PDF (1,046K) | Supplementary information
See also: Editor's summary | News and Views by Ransohoff
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells p480
Roza Nurieva, Xuexian O. Yang, Gustavo Martinez, Yongliang Zhang, Athanasia D. Panopoulos, Li Ma, Kimberly Schluns, Qiang Tian, Stephanie S. Watowich, Anton M. Jetten & Chen Dong
doi:10.1038/nature05969
First paragraph | Full Text | PDF (411K) | Supplementary information
See also: News and Views by Palmer & Weaver
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells p484
Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B. Strom, Mohamed Oukka & Vijay K. Kuchroo
doi:10.1038/nature05970
First paragraph | Full Text | PDF (604K) | Supplementary information
See also: News and Views by Palmer & Weaver
Functional diversification of closely related ARF-GEFs in protein secretion and recycling p488
Sandra Richter, Niko Geldner, Jarmo Schrader, Hanno Wolters, York-Dieter Stierhof, Gabino Rios, Csaba Koncz, David G. Robinson & Gerd Jürgens
doi:10.1038/nature05967
First paragraph | Full Text | PDF (2,070K) | Supplementary information
An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells p493
Ooi-kock Teh & Ian Moore
doi:10.1038/nature06023
First paragraph | Full Text | PDF (1,426K) | Supplementary information
A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence p497
Delphine Chinchilla, Cyril Zipfel, Silke Robatzek, Birgit Kemmerling, Thorsten Nürnberger, Jonathan D. G. Jones, Georg Felix & Thomas Boller
doi:10.1038/nature05999
First paragraph | Full Text | PDF (616K) | Supplementary information
See also: Editor's summary
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response p501
Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba & Tadatsugu Taniguchi
doi:10.1038/nature06013
First paragraph | Full Text | PDF (420K) | Supplementary information
See also: Editor's summary | News and Views by Chi & Flavell
Naturejobs
ProspectProspect p507
Will new data suggest ways for PhD students to shorten their time to degree?
Gene Russo
doi:10.1038/nj7152-507a
Career Views
Gerd Kempermann, professor, Center for Regenerative Therapies, Dresden, Germany p508
Stem-cell scientist moves to new centre in Germany.
Virginia Gewin
doi:10.1038/nj7152-508a
Order of merit p508
There's a better way to determine authorship order.
Christine Beveridge & Suzanne Morris
doi:10.1038/nj7152-508b
Isolation p508
Maternity leave makes me miss the lab.
Moira Sheehan
doi:10.1038/nj7152-508c
Futures
And on gloomy Sunday... p510
There goes the neighbourhood.
Anthony S. Haines
doi:10.1038/448510a
