Table of contents


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Editorials

Dolly's legacy p795

Ten years on, mammalian cloning is moving forward with central societal issues remaining unresolved. Yet human reproductive cloning seems inevitable.

doi:10.1038/445795a

See also: Editor's summary


Rise to the challenge p795

The European Research Council, launched next week, is a stimulus for weak universities.

doi:10.1038/445795b


Regulatory fist-fight p796

A move to wrest control of US federal regulations from government agencies should be opposed.

doi:10.1038/445796a


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Research Highlights

Research highlights p798

doi:10.1038/445798a


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News

Special Report

Cloning special: Dolly: a decade on p800

Ten years ago, the birth of Dolly the sheep sparked a media frenzy and a prolonged ethical debate. Today, the arguments have switched focus to stem cells, and the research itself is beginning to change tack.

Meredith Wadman

doi:10.1038/445800a

See also: Editor's summary


Cloning special: Dolly: a hard act to follow p802

Cloning mammals has proved to be more difficult than researchers hoped.

Erika Check

doi:10.1038/445802a


Direct view of a dark and distant world p803

Spectra from gas giant hint at a planet shrouded in cloud.

Katharine Sanderson

doi:10.1038/445803a


Japanese TV show admits faking science p804

Programme makers redubbed interviews and changed experimental results.

David Cyranoski

doi:10.1038/445804a


Sidelines p806

doi:10.1038/445806a


Role of state climatologist comes under scrutiny p806

Local governments crack down on unorthodox views.

Michael Hopkin

doi:10.1038/445806b


News in brief p807

doi:10.1038/445807a


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Business

Spy in the sky p808

Except for their use in military reconnaissance, unmanned aircraft have been seen mainly as expensive toys. But as technologies mature, Ned Stafford asks when drones are set to go commercial.

doi:10.1038/445808a


In brief p809

doi:10.1038/445809a


Market watch p809

Colin Macilwain

doi:10.1038/445809b


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News Features

Forensic science: Ghost buster p811

An Italian scientist revived the hunt for the mafia's boss of bosses. Declan Butler reports.

doi:10.1038/445811a

See also: Editor's summary


Indonesian eruption: Muddy waters p812

How did a mud volcano come to destroy an Indonesian town? David Cyranoski reports from Sidoarjo.

doi:10.1038/445812a

See also: Editor's summary


Plant biology: The flower of seduction p816

Hundreds of orchid species lure their pollinators with the promise of sex, only to send them away unfulfilled. Heidi Ledford looks at how dishonesty gives them the evolutionary edge.

doi:10.1038/445816a

See also: Editor's summary


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Correspondence

Concrete evidence that volcanoes can be stopped p818

John Carpenter

doi:10.1038/445818a


Newspaper scare headlines can be counter-productive p818

Mike Hulme

doi:10.1038/445818b


Niche drugs aren't a cheap alternative to blockbusters p818

W. Ross Tracey

doi:10.1038/445818c


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Books and Arts

Calamity gene p819

When biotechnology spins out of control.

Michael A. Goldman reviews Next by Michael Crichton

doi:10.1038/445819a


The two faces of science p820

Richard Yeo reviews The Intelligibility of Nature: How Science Makes Sense of the World by Peter Dear

doi:10.1038/445820a


Ordering according to size p821

Victor Smetacek reviews Why Size Matters: From Bacteria to Blue Whales by John Tyler Bonner

doi:10.1038/445821a


For the love of Greece p822

doi:10.1038/445822a


The pleasure principle p822

Tim D. Spector reviews The Science of Orgasm by Barry R. Komisaruk, Carlos Beyer-Flores and Beverly Whipple

doi:10.1038/445822b


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Essay

Connections

Bringing cartoons to life p823

To understand cells as dynamic systems, mathematical tools are needed to fill the gap between molecular interactions and physiological consequences.

John J. Tyson

doi:10.1038/445823a


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News and Views

Animal Behaviour: Planning for breakfast p825

It is commonly believed that planning for the future is a skill unique to humans. Could other animals, even those as evolutionarily distant as western scrub-jays, share this skill with us?

Sara J. Shettleworth

doi:10.1038/445825a

See also: Editor's summary


Organic chemistry: A tuxedo for iodine atoms p826

Iodine atoms can be fitted with a chemical jacket to control the conversion of simple carbon chains into complex iodine-containing molecules. Previously, such reactions were only possible with enzymes.

Phil S. Baran and Thomas J. Maimone

doi:10.1038/445826a


Biomechanics: Fish feeding hardly a drag p827

Mathematical simulations of prey capture in an aqueous environment, tuned by observational data, have produced a fresh view of the forces generated by suction feeding in fishes.

Mason N. Dean and Adam P. Summers

doi:10.1038/445827a


50 & 100 Years Ago p827

doi:10.1038/445827b


Human genetics: Variants in common diseases p828

Most common diseases arise from interaction between multiple genetic variations and factors such as diet. Studies of such diseases that exploit the rich data on variation in the human genome are just beginning.

Nelson B. Freimer and Chiara Sabatti

doi:10.1038/nature05568

See also: Editor's summary


Music: Let the people sing p829

Richard Webb

doi:10.1038/445829a


Glaciology: Lubricating lakes p830

More than 150 subglacial lakes have been discovered beneath the Antarctic ice sheet. The four most recent additions, found right at the start of fast flow in a large ice stream, suggest that the lakes influence ice dynamics.

Jack Kohler

doi:10.1038/445830a

See also: Editor's summary


Physical chemistry: Oil on troubled waters p831

The nature of the boundary between water and oil is crucial to many nanometre-scale assembly processes, including protein folding. But until now, what the interface really looks like remained in dispute.

David Chandler

doi:10.1038/445831a


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Insight: Skin Biology

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Insight: Skin Biology

Skin Biology p833

Barbara Marte, Joshua Finkelstein and Lesley Anson

doi:10.1038/445833a


Scratching the surface of skin development p834

Elaine Fuchs

doi:10.1038/nature05659


Melanocyte biology and skin pigmentation p843

Jennifer Y. Lin and David E. Fisher

doi:10.1038/nature05660


Melanoma biology and new targeted therapy p851

Vanessa Gray-Schopfer, Claudia Wellbrock and Richard Marais

doi:10.1038/nature05661


Mechanisms of sensory transduction in the skin p858

Ellen A. Lumpkin and Michael J. Caterina

doi:10.1038/nature05662


Pathogenesis and therapy of psoriasis p866

Michelle A. Lowes, Anne M. Bowcock and James G. Krueger

doi:10.1038/nature05663


Progress and opportunities for tissue-engineered skin p874

Sheila MacNeil

doi:10.1038/nature05664



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Brief Communications Arising

Bone Metastasis: Can osteoclasts be excluded? pE19

T. John Martin and Gregory R. Mundy

doi:10.1038/nature05657


Bone Metastasis: Can osteoclasts be excluded? (Reply) pE19

D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger

doi:10.1038/nature05658


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Articles

A genome-wide association study identifies novel risk loci for type 2 diabetes p881

Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos and Philippe Froguel

doi:10.1038/nature05616

See also: Editor's summary | News and Views by Freimer & Sabatti


Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver p886

Ben Z. Stanger, Akemi J. Tanaka and Douglas A. Melton

doi:10.1038/nature05537

See also: Editor's summary


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Letters

A spectrum of an extrasolar planet p892

L. Jeremy Richardson, Drake Deming, Karen Horning, Sara Seager and Joseph Harrington

doi:10.1038/nature05636

See also: Editor's summary


Quantum nature of a strongly coupled single quantum dot–cavity system p896

K. Hennessy, A. Badolato, M. Winger, D. Gerace, M. Atatüre, S. Gulde, S. Fält, E. L. Hu and A. Imamog brevelu

doi:10.1038/nature05586

See also: Editor's summary


Enantioselective halocyclization of polyprenoids induced by nucleophilic phosphoramidites p900

Akira Sakakura, Atsushi Ukai and Kazuaki Ishihara

doi:10.1038/nature05553

See also: News and Views by Baran & Maimone


Large subglacial lakes in East Antarctica at the onset of fast-flowing ice streams p904

Robin E. Bell, Michael Studinger, Christopher A. Shuman, Mark A. Fahnestock and Ian Joughin

doi:10.1038/nature05554

See also: Editor's summary | News and Views by Kohler


Moisture transport across Central America as a positive feedback on abrupt climatic changes p908

Guillaume Leduc, Laurence Vidal, Kazuyo Tachikawa, Frauke Rostek, Corinne Sonzogni, Luc Beaufort and Edouard Bard

doi:10.1038/nature05578


Female fur seals show active choice for males that are heterozygous and unrelated p912

J. I. Hoffman, J. Forcada, P. N. Trathan and W. Amos

doi:10.1038/nature05558

See also: Editor's summary


An African origin for the intimate association between humans and Helicobacter pylori p915

Bodo Linz, François Balloux, Yoshan Moodley, Andrea Manica, Hua Liu, Philippe Roumagnac, Daniel Falush, Christiana Stamer, Franck Prugnolle, Schalk W. van der Merwe, Yoshio Yamaoka, David Y. Graham, Emilio Perez-Trallero, Torkel Wadstrom, Sebastian Suerbaum and Mark Achtman

doi:10.1038/nature05562

See also: Editor's summary


Planning for the future by western scrub-jays p919

C. R. Raby, D. M. Alexis, A. Dickinson and N. S. Clayton

doi:10.1038/nature05575

See also: Editor's summary | News and Views by Shettleworth


eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans p922

Popi Syntichaki, Kostoula Troulinaki and Nektarios Tavernarakis

doi:10.1038/nature05603

See also: Editor's summary


APOBEC3 inhibits mouse mammary tumour virus replication in vivo p927

Chioma M. Okeoma, Nika Lovsin, B. Matija Peterlin and Susan R. Ross

doi:10.1038/nature05540


Foxp3 occupancy and regulation of key target genes during T-cell stimulation p931

Alexander Marson, Karsten Kretschmer, Garrett M. Frampton, Elizabeth S. Jacobsen, Julia K. Polansky, Kenzie D. MacIsaac, Stuart S. Levine, Ernest Fraenkel, Harald von Boehmer and Richard A. Young

doi:10.1038/nature05478


Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells p936

Ye Zheng, Steven Z. Josefowicz, Arnold Kas, Tin-Tin Chu, Marc A. Gavin and Alexander Y. Rudensky

doi:10.1038/nature05563


TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 p941

Huaqing Cai, Sidney Yu, Shekar Menon, Yiying Cai, Darina Lazarova, Chunmei Fu, Karin Reinisch, Jesse C. Hay and Susan Ferro-Novick

doi:10.1038/nature05527


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Naturejobs

Prospect

Prospects p945

Translating global science extends beyond language.

Paul Smaglik

doi:10.1038/nj7130-945a


Careers and Recruitment

Count on it p946

It's a tough brief to fill, but geneticists with mathematical and computing skills find jobs easy to get. Virginia Gewin reports.

Virginia Gewin

doi:10.1038/nj7130-946a


Career Views

Colin Masters, executive director, Mental Health Research Institute of Victoria, Australia p948

Colin Masters prepares to tackle psychiatric disorders.

Virginia Gewin

doi:10.1038/nj7130-948a


Torn between two ladders p948

Jumping to a new discipline brings both anxiety and satisfaction.

Alexander Griekspoor

doi:10.1038/nj7130-948b


Smart moves p948

Balancing work and family has made me a better scientist.

Moira Sheehan

doi:10.1038/nj7130-948c


Recruitment

The inside track from academia and industry: Crossing boundaries, hitting barriers p950

Interdisciplinary research may be lauded, but it's not yet rewarded.

Adina Paytan & Mary Lou Zoback

doi:10.1038/nj7130-950a


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