Table of contents
Volume 445 Number 7130 pp795-950
Editorials
Dolly's legacy p795
Ten years on, mammalian cloning is moving forward with central societal issues remaining unresolved. Yet human reproductive cloning seems inevitable.
doi:10.1038/445795a
See also: Editor's summary
Rise to the challenge p795
The European Research Council, launched next week, is a stimulus for weak universities.
doi:10.1038/445795b
Regulatory fist-fight p796
A move to wrest control of US federal regulations from government agencies should be opposed.
doi:10.1038/445796a
News
Special ReportCloning special: Dolly: a decade on p800
Ten years ago, the birth of Dolly the sheep sparked a media frenzy and a prolonged ethical debate. Today, the arguments have switched focus to stem cells, and the research itself is beginning to change tack.
Meredith Wadman
doi:10.1038/445800a
See also: Editor's summary
Cloning special: Dolly: a hard act to follow p802
Cloning mammals has proved to be more difficult than researchers hoped.
Erika Check
doi:10.1038/445802a
Direct view of a dark and distant world p803
Spectra from gas giant hint at a planet shrouded in cloud.
Katharine Sanderson
doi:10.1038/445803a
Japanese TV show admits faking science p804
Programme makers redubbed interviews and changed experimental results.
David Cyranoski
doi:10.1038/445804a
Sidelines p806
doi:10.1038/445806a
Role of state climatologist comes under scrutiny p806
Local governments crack down on unorthodox views.
Michael Hopkin
doi:10.1038/445806b
Business
Spy in the sky p808
Except for their use in military reconnaissance, unmanned aircraft have been seen mainly as expensive toys. But as technologies mature, Ned Stafford asks when drones are set to go commercial.
doi:10.1038/445808a
In brief p809
doi:10.1038/445809a
Market watch p809
Colin Macilwain
doi:10.1038/445809b
News Features
Forensic science: Ghost buster p811
An Italian scientist revived the hunt for the mafia's boss of bosses. Declan Butler reports.
doi:10.1038/445811a
See also: Editor's summary
Indonesian eruption: Muddy waters p812
How did a mud volcano come to destroy an Indonesian town? David Cyranoski reports from Sidoarjo.
doi:10.1038/445812a
See also: Editor's summary
Plant biology: The flower of seduction p816
Hundreds of orchid species lure their pollinators with the promise of sex, only to send them away unfulfilled. Heidi Ledford looks at how dishonesty gives them the evolutionary edge.
doi:10.1038/445816a
See also: Editor's summary
Correspondence
Concrete evidence that volcanoes can be stopped p818
John Carpenter
doi:10.1038/445818a
Newspaper scare headlines can be counter-productive p818
Mike Hulme
doi:10.1038/445818b
Niche drugs aren't a cheap alternative to blockbusters p818
W. Ross Tracey
doi:10.1038/445818c
Books and Arts
Calamity gene p819
When biotechnology spins out of control.
Michael A. Goldman reviews Next by Michael Crichton
doi:10.1038/445819a
The two faces of science p820
Richard Yeo reviews The Intelligibility of Nature: How Science Makes Sense of the World by Peter Dear
doi:10.1038/445820a
Ordering according to size p821
Victor Smetacek reviews Why Size Matters: From Bacteria to Blue Whales by John Tyler Bonner
doi:10.1038/445821a
For the love of Greece p822
doi:10.1038/445822a
The pleasure principle p822
Tim D. Spector reviews The Science of Orgasm by Barry R. Komisaruk, Carlos Beyer-Flores and Beverly Whipple
doi:10.1038/445822b
Essay
ConnectionsBringing cartoons to life p823
To understand cells as dynamic systems, mathematical tools are needed to fill the gap between molecular interactions and physiological consequences.
John J. Tyson
doi:10.1038/445823a
News and Views
Animal Behaviour: Planning for breakfast p825
It is commonly believed that planning for the future is a skill unique to humans. Could other animals, even those as evolutionarily distant as western scrub-jays, share this skill with us?
Sara J. Shettleworth
doi:10.1038/445825a
See also: Editor's summary
Organic chemistry: A tuxedo for iodine atoms p826
Iodine atoms can be fitted with a chemical jacket to control the conversion of simple carbon chains into complex iodine-containing molecules. Previously, such reactions were only possible with enzymes.
Phil S. Baran and Thomas J. Maimone
doi:10.1038/445826a
Biomechanics: Fish feeding hardly a drag p827
Mathematical simulations of prey capture in an aqueous environment, tuned by observational data, have produced a fresh view of the forces generated by suction feeding in fishes.
Mason N. Dean and Adam P. Summers
doi:10.1038/445827a
50 & 100 Years Ago p827
doi:10.1038/445827b
Human genetics: Variants in common diseases p828
Most common diseases arise from interaction between multiple genetic variations and factors such as diet. Studies of such diseases that exploit the rich data on variation in the human genome are just beginning.
Nelson B. Freimer and Chiara Sabatti
doi:10.1038/nature05568
See also: Editor's summary
Music: Let the people sing p829
Richard Webb
doi:10.1038/445829a
Glaciology: Lubricating lakes p830
More than 150 subglacial lakes have been discovered beneath the Antarctic ice sheet. The four most recent additions, found right at the start of fast flow in a large ice stream, suggest that the lakes influence ice dynamics.
Jack Kohler
doi:10.1038/445830a
See also: Editor's summary
Physical chemistry: Oil on troubled waters p831
The nature of the boundary between water and oil is crucial to many nanometre-scale assembly processes, including protein folding. But until now, what the interface really looks like remained in dispute.
David Chandler
doi:10.1038/445831a
Insight: Skin Biology -
Produced with support from:
Insight: Skin Biology
Skin Biology p833
Barbara Marte, Joshua Finkelstein and Lesley Anson
doi:10.1038/445833a
Scratching the surface of skin development p834
Elaine Fuchs
doi:10.1038/nature05659
Abstract | Full Text | PDF (2,253K)
Melanocyte biology and skin pigmentation p843
Jennifer Y. Lin and David E. Fisher
doi:10.1038/nature05660
Abstract | Full Text | PDF (791K)
Melanoma biology and new targeted therapy p851
Vanessa Gray-Schopfer, Claudia Wellbrock and Richard Marais
doi:10.1038/nature05661
Abstract | Full Text | PDF (805K)
Mechanisms of sensory transduction in the skin p858
Ellen A. Lumpkin and Michael J. Caterina
doi:10.1038/nature05662
Abstract | Full Text | PDF (2,313K)
Pathogenesis and therapy of psoriasis p866
Michelle A. Lowes, Anne M. Bowcock and James G. Krueger
doi:10.1038/nature05663
Abstract | Full Text | PDF (1,183K)
Progress and opportunities for tissue-engineered skin p874
Sheila MacNeil
doi:10.1038/nature05664
Abstract | Full Text | PDF (1,026K)
Brief Communications Arising
Bone Metastasis: Can osteoclasts be excluded? pE19
T. John Martin and Gregory R. Mundy
doi:10.1038/nature05657
First paragraph | Full Text | PDF (105K)
Bone Metastasis: Can osteoclasts be excluded? (Reply) pE19
D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger
doi:10.1038/nature05658
First paragraph | Full Text | PDF (105K)
Articles
A genome-wide association study identifies novel risk loci for type 2 diabetes p881
Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos and Philippe Froguel
doi:10.1038/nature05616
Abstract | Full Text | PDF (431K) | Supplementary information
See also: Editor's summary | News and Views by Freimer & Sabatti
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver p886
Ben Z. Stanger, Akemi J. Tanaka and Douglas A. Melton
doi:10.1038/nature05537
Abstract | Full Text | PDF (942K) | Supplementary information
See also: Editor's summary
Letters
A spectrum of an extrasolar planet p892
L. Jeremy Richardson, Drake Deming, Karen Horning, Sara Seager and Joseph Harrington
doi:10.1038/nature05636
First paragraph | Full Text | PDF (275K) | Supplementary information
See also: Editor's summary
Quantum nature of a strongly coupled single quantum dot–cavity system p896
K. Hennessy,
A. Badolato,
M. Winger,
D. Gerace,
M. Atatüre,
S. Gulde,
S. Fält,
E. L. Hu
and
A. Imamo
lu
doi:10.1038/nature05586
First paragraph | Full Text | PDF (592K) | Supplementary information
See also: Editor's summary
Enantioselective halocyclization of polyprenoids induced by nucleophilic phosphoramidites p900
Akira Sakakura, Atsushi Ukai and Kazuaki Ishihara
doi:10.1038/nature05553
First paragraph | Full Text | PDF (272K) | Supplementary information
See also: News and Views by Baran & Maimone
Large subglacial lakes in East Antarctica at the onset of fast-flowing ice streams p904
Robin E. Bell, Michael Studinger, Christopher A. Shuman, Mark A. Fahnestock and Ian Joughin
doi:10.1038/nature05554
First paragraph | Full Text | PDF (1,763K) | Supplementary information
See also: Editor's summary | News and Views by Kohler
Moisture transport across Central America as a positive feedback on abrupt climatic changes p908
Guillaume Leduc, Laurence Vidal, Kazuyo Tachikawa, Frauke Rostek, Corinne Sonzogni, Luc Beaufort and Edouard Bard
doi:10.1038/nature05578
First paragraph | Full Text | PDF (505K) | Supplementary information
Female fur seals show active choice for males that are heterozygous and unrelated p912
J. I. Hoffman, J. Forcada, P. N. Trathan and W. Amos
doi:10.1038/nature05558
First paragraph | Full Text | PDF (175K) | Supplementary information
See also: Editor's summary
An African origin for the intimate association between humans and Helicobacter pylori p915
Bodo Linz, François Balloux, Yoshan Moodley, Andrea Manica, Hua Liu, Philippe Roumagnac, Daniel Falush, Christiana Stamer, Franck Prugnolle, Schalk W. van der Merwe, Yoshio Yamaoka, David Y. Graham, Emilio Perez-Trallero, Torkel Wadstrom, Sebastian Suerbaum and Mark Achtman
doi:10.1038/nature05562
First paragraph | Full Text | PDF (744K) | Supplementary information
See also: Editor's summary
Planning for the future by western scrub-jays p919
C. R. Raby, D. M. Alexis, A. Dickinson and N. S. Clayton
doi:10.1038/nature05575
First paragraph | Full Text | PDF (185K)
See also: Editor's summary | News and Views by Shettleworth
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans p922
Popi Syntichaki, Kostoula Troulinaki and Nektarios Tavernarakis
doi:10.1038/nature05603
First paragraph | Full Text | PDF (384K) | Supplementary information
See also: Editor's summary
APOBEC3 inhibits mouse mammary tumour virus replication in vivo p927
Chioma M. Okeoma, Nika Lovsin, B. Matija Peterlin and Susan R. Ross
doi:10.1038/nature05540
First paragraph | Full Text | PDF (307K) | Supplementary information
Foxp3 occupancy and regulation of key target genes during T-cell stimulation p931
Alexander Marson, Karsten Kretschmer, Garrett M. Frampton, Elizabeth S. Jacobsen, Julia K. Polansky, Kenzie D. MacIsaac, Stuart S. Levine, Ernest Fraenkel, Harald von Boehmer and Richard A. Young
doi:10.1038/nature05478
First paragraph | Full Text | PDF (473K) | Supplementary information
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells p936
Ye Zheng, Steven Z. Josefowicz, Arnold Kas, Tin-Tin Chu, Marc A. Gavin and Alexander Y. Rudensky
doi:10.1038/nature05563
First paragraph | Full Text | PDF (503K) | Supplementary information
TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 p941
Huaqing Cai, Sidney Yu, Shekar Menon, Yiying Cai, Darina Lazarova, Chunmei Fu, Karin Reinisch, Jesse C. Hay and Susan Ferro-Novick
doi:10.1038/nature05527
First paragraph | Full Text | PDF (376K) | Supplementary information
Naturejobs
ProspectProspects p945
Translating global science extends beyond language.
Paul Smaglik
doi:10.1038/nj7130-945a
Careers and Recruitment
Count on it p946
It's a tough brief to fill, but geneticists with mathematical and computing skills find jobs easy to get. Virginia Gewin reports.
Virginia Gewin
doi:10.1038/nj7130-946a
Career Views
Colin Masters, executive director, Mental Health Research Institute of Victoria, Australia p948
Colin Masters prepares to tackle psychiatric disorders.
Virginia Gewin
doi:10.1038/nj7130-948a
Torn between two ladders p948
Jumping to a new discipline brings both anxiety and satisfaction.
Alexander Griekspoor
doi:10.1038/nj7130-948b
Smart moves p948
Balancing work and family has made me a better scientist.
Moira Sheehan
doi:10.1038/nj7130-948c
Recruitment
The inside track from academia and industry: Crossing boundaries, hitting barriers p950
Interdisciplinary research may be lauded, but it's not yet rewarded.
Adina Paytan & Mary Lou Zoback
doi:10.1038/nj7130-950a