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Gene therapy

Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)

Nature volume 443, pages E6–E7 (2006)Cite this article

Abstract

Using a lentiviral vector and a murine model of X-linked severe combined immune deficiency (X-SCID), we have shown that mice transplanted with cells constitutively overexpressing the therapeutic gene IL2RG, a subunit found in several cytokine receptors, can develop thymic lymphomas 6 to 12 months later1. Our results contradict those of Pike-Overzet et al 2and Thrasher et al.3.

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References

  1. Woods, N.-B., Bottero, V., Schmidt, M., von Kalle, C. & Verma, I. M. Nature 440, 1123 (2006).

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Authors and Affiliations

  1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, 92037, California, USA

    Niels-Bjarne Woods, Virginie Bottero & Inder M. Verma

  2. National Center for Tumor Diseases Heidelberg and Department of Translational Oncology, German Cancer Research Center, Heidelberg, 69120, Germany

    Manfred Schmidt & Christof von Kalle

Authors
  1. Niels-Bjarne Woods
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  2. Virginie Bottero
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  3. Manfred Schmidt
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  4. Christof von Kalle
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  5. Inder M. Verma
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Woods, NB., Bottero, V., Schmidt, M. et al. Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply). Nature 443, E6–E7 (2006). https://doi.org/10.1038/nature05220

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