Editorials

Policing ourselves p383

Biologists should push forward with an effort that began in California last weekend to wrestle with the implications of synthetic biology.

doi:10.1038/441383a

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Coping with complexity p383

A more detailed understanding of scientific concepts does not lead to simplicity.

doi:10.1038/441383b

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Carbon omissions p384

The European Union's greenhouse-gas trading system needs reinforcement.

doi:10.1038/441384a

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Research Highlights

Research highlights p386

doi:10.1038/441386a

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News

Synthetic biologists try to calm fears p388

Conference discusses voluntary code of conduct.

Erika Check

doi:10.1038/441388a

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Mars explorers seek spot for touchdown p389

Planetary scientists debate where to land next.

Tony Reichhardt

doi:10.1038/441389a

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Teenager waits 40 years for recognition p390

Fossil is finally hailed as new Asian plesiosaur.

Ichiko Fuyuno

doi:10.1038/441390a

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Election fever inflames the US stem-cell debate p391

Senators tackle research policy in race for seats.

Erika Check

doi:10.1038/441391a

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Named and shamed p392

As accusations of scientific misconduct in China become rife, some fear persecution reminiscent of that used in the Cultural Revolution.

David Cyranoski

doi:10.1038/441392a

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Sidelines p394

doi:10.1038/441394a

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Physicists plead to make final tweak to fusion experiment p394

Is there time to make the ITER reactor a little fuzzy?

Geoff Brumfiel

doi:10.1038/441394b

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News in brief p396

doi:10.1038/441396a

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News Features

Genetics: What is a gene? p398

The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no clear beginning or end and RNA is a key part of the information package, reports Helen Pearson.

doi:10.1038/441398a

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The dark side of the Sun p402

The Sun occasionally hurls streams of particles towards Earth, where they can wreak havoc with satellites. Predicting these solar storms is hard, but some physicists believe we're about to face the biggest bout of solar flares in years. Stuart Clark reports.

doi:10.1038/441402a

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Business

Carbon market survives gas leaks p405

Searing volatility has led some to dismiss Europe's nascent emissions market as a farce — but it is still hanging in there. Quirin Schiermeier reports on the project's teething troubles.

doi:10.1038/441405a

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Correspondence

Climate: open review may ease acceptance of report p406

Michael MacCracken

doi:10.1038/441406a

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Climate: US has always made IPCC drafts available p406

Harlan L. Watson

doi:10.1038/441406b

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HIV denialists ignore large gap in the study they cite p406

Nathan Geffen, Nicoli Nattrass and Glenda Gray

doi:10.1038/441406c

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Books and Arts

Building on failure p407

Working out why something doesn't work is a good starting point for improving the design.

J. M. Ottino reviews Success Through Failure: The Paradox of Design by Henry Petroski

doi:10.1038/441407a

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A mammoth murder mystery p408

Alan B. Shabel reviews Twilight of the Mammoths: Ice Age Extinctions and the Rewilding of America by Paul S. Martin

doi:10.1038/441408a

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Electrifying book wins Aventis Prize p408

doi:10.1038/441408b

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Everyone hates a know-all p409

David Philip Miller reviews The Last Man Who Knew Everything: Thomas Young, the Anonymous Polymath Who Proved Newton Wrong, Explained How We See, Cured the Sick, and Deciphered the Rosetta Stone, Among Other Feats of Genius by Andrew Robinson

doi:10.1038/441409a

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Life, the Universe and entropy p409

Robert J. McEliece reviews Decoding the Universe: How the New Science of Information is Explaining Everything in the Cosmos, From our Brains to Black Holes by Charles Seife

doi:10.1038/441409b

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Science in culture: Form becomes feeling p410

Siobhan Davies looks to science to shape her dance.

Martin Kemp

doi:10.1038/441410a

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News and Views

Social sciences: A New World of differences p411

For richer, for poorer — the countries of the Americas and those of the Caribbean present stark contrasts in fortune. An explanation of those contrasts invokes branching chains of cause and effect.

Shaun Miller and Jared Diamond

doi:10.1038/441411a

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Genetics: Paramutable possibilities p413

A curious genetic phenomenon allows certain genetic instructions to be passed between generations without the gene variants involved being transmitted. Some spotty mice provide clues to how this might happen.

Paul D. Soloway

doi:10.1038/441413a

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Nanomaterials: Display of flexibility p414

Treated the right way, carbon nanotubes can be moulded into large, flexible electron-emitting sheets. The material is one half of what's needed for an electronic display you could fold up and slip in your pocket.

László Forró

doi:10.1038/441414a

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Immunology: Adaptable innate killers p415

Natural killer cells are versatile white blood cells that act in the innate immune system. Quite how adaptable they can be in the absence of other, more specialized, immune cells comes as a surprise.

Peter Parham

doi:10.1038/441415a

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Meteoritics: How to make a chondrule p416

Chondrules, the stony, seed-like grains in meteorites, were formed when some event melted rock in the solar nebula. The latest analyses narrow the possible 'when', 'where' and 'how' of that process.

Steve Desch

doi:10.1038/441416a

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Ecology: Paradox of the clumps p417

A fresh look at an established model in ecology has generated insights into how species coexist with each other. But it has also raised a vexed question: what constitutes the ecological identity of species?

Sean Nee and Nick Colegrave

doi:10.1038/441417a

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Materials science: Film review p418

Maria Bellantone

doi:10.1038/441418a

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Stem cells: Good, bad and reformable p418

The ability of stem cells to continuously supply vast numbers of cells is magnificent, but it can be devastating if it runs amok, as in some tumours. So what makes a normal stem cell turn bad, and can it be redeemed?

Viktor Janzen and David T. Scadden

doi:10.1038/441418b

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Brief Communications

Ecology: Avoidance of disease by social lobsters p421

These gregarious animals shun lobsters that carry a lethal virus, even when they still seem to be healthy.

Donald C. Behringer, Mark J. Butler and Jeffrey D. Shields

doi:10.1038/441421a

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Brief Communications Arising

Correspondence patterns: Mechanisms and models of human dynamics pE5

Alex Kentsis

doi:10.1038/nature04901

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Correspondence patterns: Mechanisms and models of human dynamics (Reply) pE5

J. G. Oliveira and A.-L. Barabàsi

doi:10.1038/nature04902

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Articles

Long -ray bursts and core-collapse supernovae have different environments p463

A. S. Fruchter, A. J. Levan, L. Strolger, P. M. Vreeswijk, S. E. Thorsett, D. Bersier, I. Burud, J. M. Castro Cerón, A. J. Castro-Tirado, C. Conselice, T. Dahlen, H. C. Ferguson, J. P. U. Fynbo, P. M. Garnavich, R. A. Gibbons, J. Gorosabel, T. R. Gull, J. Hjorth, S. T. Holland, C. Kouveliotou, Z. Levay, M. Livio, M. R. Metzger, P. E. Nugent, L. Petro, E. Pian, J. E. Rhoads, A. G. Riess, K. C. Sahu, A. Smette, N. R. Tanvir, R. A. M. J. Wijers and S. E. Woosley

doi:10.1038/nature04787

Abstract | Full Text | PDF (363K) | Supplementary information

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RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse p469

Minoo Rassoulzadegan, Valérie Grandjean, Pierre Gounon, Stéphane Vincent, Isabelle Gillot and François Cuzin

doi:10.1038/nature04674

Abstract | Full Text | PDF (442K) | Supplementary information

See also: Editor's summary | News and Views by Soloway

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells p475

Ömer H. Yilmaz, Riccardo Valdez, Brian K. Theisen, Wei Guo, David O. Ferguson, Hong Wu and Sean J. Morrison

doi:10.1038/nature04703

Abstract | Full Text | PDF (989K) | Supplementary information

See also: Editor's summary | News and Views by Janzen & Scadden

Letters

Chondrule formation in particle-rich nebular regions at least hundreds of kilometres across p483

Jeffrey N. Cuzzi and Conel M. O'D. Alexander

doi:10.1038/nature04834

First paragraph | Full Text | PDF (139K) | Supplementary information

See also: News and Views by Desch

Detection of magnetic circular dichroism using a transmission electron microscope p486

P. Schattschneider, S. Rubino, C. Hébert, J. Rusz, J. Kune, P. Novák, E. Carlino, M. Fabrizioli, G. Panaccione and G. Rossi

doi:10.1038/nature04778

First paragraph | Full Text | PDF (192K) | Supplementary information

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Ge/Si nanowire heterostructures as high-performance field-effect transistors p489

Jie Xiang, Wei Lu, Yongjie Hu, Yue Wu, Hao Yan and Charles M. Lieber

doi:10.1038/nature04796

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Long-term eruptive activity at a submarine arc volcano p494

Robert W. Embley, William W. Chadwick, Jr, Edward T. Baker, David A. Butterfield, Joseph A. Resing, Cornel E.J. de Ronde, Verena Tunnicliffe, John E. Lupton, S. Kim Juniper, Kenneth H. Rubin, Robert J. Stern, Geoffrey T. Lebon, Ko-ichi Nakamura, Susan G. Merle, James R. Hein, Douglas A. Wiens and Yoshihiko Tamura

doi:10.1038/nature04762

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Resource competition and social conflict in experimental populations of yeast p498

R. Craig MacLean and Ivana Gudelj

doi:10.1038/nature04624

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A simple rule for the evolution of cooperation on graphs and social networks p502

Hisashi Ohtsuki, Christoph Hauert, Erez Lieberman and Martin A. Nowak

doi:10.1038/nature04605

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Homology of arthropod anterior appendages revealed by Hox gene expression in a sea spider p506

Muriel Jager, Jérôme Murienne, Céline Clabaut, Jean Deutsch, Hervé Le Guyader and Michaël Manuel

doi:10.1038/nature04591

First paragraph | Full Text | PDF (201K) | Supplementary information

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Somatic stem cell niche tropism in Wolbachia p509

Horacio M. Frydman, Jennifer M. Li, Drew N. Robson and Eric Wieschaus

doi:10.1038/nature04756

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S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration p513

Takashi Uehara, Tomohiro Nakamura, Dongdong Yao, Zhong-Qing Shi, Zezong Gu, Yuliang Ma, Eliezer Masliah, Yasuyuki Nomura and Stuart A. Lipton

doi:10.1038/nature04782

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention p518

Jiwang Zhang, Justin C. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, Jason T. Ross, Jeffrey S. Haug, Dawn Rupp, Kimberly S. Porter-Westpfahl, Leanne M. Wiedemann, Hong Wu and Linheng Li

doi:10.1038/nature04747

First paragraph | Full Text | PDF (589K) | Supplementary information

See also: Editor's summary | News and Views by Janzen & Scadden

Identification of a tumour suppressor network opposing nuclear Akt function p523

Lloyd C. Trotman, Andrea Alimonti, Pier Paolo Scaglioni, Jason A. Koutcher, Carlos Cordon-Cardo and Pier Paolo Pandolfi

doi:10.1038/nature04809

First paragraph | Full Text | PDF (539K) | Supplementary information

GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission p528

Aurélien Roux, Katherine Uyhazi, Adam Frost and Pietro De Camilli

doi:10.1038/nature04718

First paragraph | Full Text | PDF (471K) | Supplementary information

Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis p532

Gloria A. Brar, Brendan M. Kiburz, Yi Zhang, Ji-Eun Kim, Forest White and Angelika Amon

doi:10.1038/nature04794

First paragraph | Full Text | PDF (501K) | Supplementary information

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways p537

Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar and Mark A. Kay

doi:10.1038/nature04791

First paragraph | Full Text | PDF (549K) | Supplementary information

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Naturejobs

Prospect p543

Fledgling UK postdoc association can learn from other efforts.

Paul Smaglik

doi:10.1038/nj7092-543a

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Animal intelligence p544

Use of animals for testing early in the drug-development process aims to provide vital information to make new drugs safe and effective — and the process is being constantly refined. Hannah Hoag finds out what is involved.

Hannah Hoag

doi:10.1038/nj7092-544a

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Jai Nagarkatti, president and chief executive, Sigma-Aldrich, St Louis, Missouri p546

Jai Nagarkatti shows loyalty to his company.

Virginia Gewin

doi:10.1038/nj7092-546a

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Britain's postdocs unite p546

UK postdocs form association.

John Bothwell

doi:10.1038/nj7092-546b

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Clocking out p546

The shifting passage of time in graduate school.

Milan de Vries

doi:10.1038/nj7092-546c

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Futures

Paratext p548

Step into another world.

Scarlett Thomas

doi:10.1038/441548a

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