Supplementary information
From the following article:
Silencing of microRNAs in vivo with 'antagomirs'
Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan & Markus Stoffel
Nature 438, 685-689(1 December 2005)
doi:10.1038/nature04303
Supplementary Figure 1
MiR-122 is quantitatively recovered from a duplex formed with antagomir-122.
Supplementary Figure 2
Annealing antagomir-122 to liver RNA in vitro does not alter miR-122 detection in formamide-containing gels.
Supplementary Figure 3
Sustained silencing of miR-122 after injection of antagomir-122 into mice.
Supplementary Figure 4
Antagomirs specifically target miRNAs that derive from the same primary transcript.
Supplementary Table 1
Affymetrix gene expression analysis of genes up-regulated 
1.4-fold in livers of mice treated with antagomir-122 compared to control mm-antagomir-122.
Supplementary Table 2
Affymetrix gene expression analysis of genes down-regulated 1.4-fold in livers of mice treated with antagomir-122 compared to control mm-antagomir-122. Probe sets with "absent (A)" to "absent" changes were excluded.
Supplementary Notes
This contains Supplementary Figure Legends and Supplementary Notes.
Supplementary Methods
This file contains additional details of the methods used in this study.
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