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Editorials

Let data speak to data p531

Web tools now allow data sharing and informal debate to take place alongside published papers. But to take full advantage, scientists must embrace a culture of sharing and rethink their vision of databases.

doi:10.1038/438531a


Life at the edge p531

Successes in structural studies of membrane proteins deserve to be celebrated.

doi:10.1038/438531b


Stem-cell probe needed p532

South Korea would benefit from investigating what went wrong in its leading stem-cell lab.

doi:10.1038/438532a


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Research Highlights

Research highlights p534

doi:10.1038/438534a


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News

Clone star admits lies over eggs p536

Calls for fuller investigation as national hero confesses.

David Cyranoski and Erika Check

doi:10.1038/438536a


Antarctic ice puts climate predictions to the test p536

Frozen record of the past reveals models' shortcomings.

Michael Hopkin

doi:10.1038/438536b


Titan: tapping the flood of data p538

The first analyses of the Huygens mission to Titan are published this week. Mark Peplow charts the satellite's transition from fogbound moon to familiar landscape, and finds out why scientists long to return.

doi:10.1038/438538a


Rocky future predicted for labs that rely on postdocs p541

Dependence on foreign expertise threatens US research.

Geoff Brumfiel

doi:10.1038/438541a


Sidelines p541

doi:10.1038/438541b


Europe's cash crisis puts space plans under threat p542

ESA budget review puts mission to Mercury in jeopardy

Jenny Hogan

doi:10.1038/438542a


Hayabusa ready to head home with asteroid sample p542

Concern over engine damage mars celebrations.

Ichiko Fuyuno

doi:10.1038/438542b


News in brief p544

doi:10.1038/438544a


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News Features

Science in the web age: The expanding electronic universe p547

doi:10.1038/438547a

See also: Editor's summary


Science in the web age: Joint efforts p548

At its best, academia is a marketplace of ideas. But many scientists are reluctant to embrace the latest web tools that would allow them to communicate their ideas in new ways, says Declan Butler.

doi:10.1038/438548a


Science in the web age: The real death of print p550

Despite clashes with publishers over copyright, Google's plan to make millions of books available online is turning the tide for efforts to digitize the world's literature. Andreas von Bubnoff tracks the demise of the printed page.

doi:10.1038/438550a


Science in the web age: Start your engines p554

Google has launched another challenge to commercial search services — this time aimed at scientists. But is the new engine running as smoothly as its fans hope? Jim Giles investigates.

doi:10.1038/438554a


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Business

Swiss star finds it tough at the top p557

Serono is calling in outside advice. Colin Macilwain investigates the future of Europe's leading biotech firm.

doi:10.1038/438557a


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Correspondence

Automated grading of research performance clearly fails to measure up p559

N. Haeffner-Cavaillon, C. Graillot-Gak and C. Bréchot

doi:10.1038/438559a


Animal-rights zealots put wildlife welfare at risk p559

Peter B. Banks

doi:10.1038/438559b


Evaluation bias hits women who aren't twice as good p559

Marlene Zuk and Gunilla Rosenqvist

doi:10.1038/438559c


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Books and Arts

Different class p561

The 'big three' universities in the United States are upholding a long tradition of élitism.

John Aubrey Douglass reviews The Chosen: The Hidden History of Admissions and Exclusion at Harvard, Yale, and Princeton

doi:10.1038/438561a


Cultural reflections p562

Howard P. Segal reviews Hubris and Hybrids: A Cultural History of Technology and Science

doi:10.1038/438562a


An inside view of the Universe p563

Shawn Cruzen reviews Theaters of Time and Space: American Planetaria, 1930–1970

doi:10.1038/438563a


Science in culture: Dying for a drink p564

Evolution goes backwards in the latest Guinness advertisement.

Martin Kemp

doi:10.1038/438564a


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News and Views

Oceanography: The Atlantic heat conveyor slows p565

Computer simulations predict that global warming will weaken the ocean circulation that transports heat from the tropics to higher latitudes in the North Atlantic. Such an effect has now been detected.

Detlef Quadfasel

doi:10.1038/438565a

See also: Editor's summary


Biophysics: Assembly line inspection p566

Many of the biochemical events that occur in a cell are performed by huge complexes of proteins and nucleic acids. A cunning approach promises to show how the components convene to make a functioning 'machine'.

Sarah A. Woodson

doi:10.1038/438566a

See also: Editor's summary


50 & 100 years ago p567

doi:10.1038/438567a


Cell biology: A greasy grip p569

How do the lipids and proteins of the cell membrane interact to create a functioning barrier for the cell? A high-resolution structure of a membrane protein reveals intimate contacts with its lipid neighbours.

Anthony G. Lee

doi:10.1038/438569a

See also: Editor's summary


Planetary science: Clays in the history of Mars p570

The stream of revelations from Mars continues. The latest news — the discovery of clays in ancient terrains — helps to fill in the picture of the past existence of liquid water on the planet's surface.

Horton Newsom

doi:10.1038/438570a

See also: Editor's summary


Cell biology: Protein choreography p571

Just under the cell surface, proteins engage in an intricate ballet to drive a transport process called endocytosis. Much is known about the individual dancers, but now the choreography is revealed.

Mara C. Duncan and Gregory S. Payne

doi:10.1038/438571a


Correction p573

doi:10.1038/438573a


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Brief Communications

Fruit bats as reservoirs of Ebola virus p575

Bat species eaten by people in central Africa show evidence of symptomless Ebola infection.

Eric M. Leroy, Brice Kumulungui, Xavier Pourrut, Pierre Rouquet, Alexandre Hassanin, Philippe Yaba, André Délicat, Janusz T. Paweska, Jean-Paul Gonzalez and Robert Swanepoel

doi:10.1038/438575a

See also: Editor's summary


Palaeoecology: A gigantic fossil arthropod trackway p576

Martin A. Whyte

doi:10.1038/438576a

See also: Editor's summary


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Brief Communications Arising

Geochronology: Age of Mexican ash with alleged 'footprints' pE7

Paul R. Renne, Joshua M. Feinberg, Michael R. Waters, Joaquin Arroyo-Cabrales, Patricia Ochoa-Castillo, Mario Perez-Campa and Kim B. Knight

doi:10.1038/nature04425

See also: Editor's summary


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Insight: Membrane biology


Insight: Membrane biology

Membrane biology p577

Deepa Nath

doi:10.1038/438577a


Membranes are more mosaic than fluid p578

Donald M. Engelman

doi:10.1038/nature04394


Solving the membrane protein folding problem p581

James U. Bowie

doi:10.1038/nature04395


Membrane curvature and mechanisms of dynamic cell membrane remodelling p590

Harvey T. McMahon and Jennifer L. Gallop

doi:10.1038/nature04396


Organelle identity and the signposts for membrane traffic p597

Rudy Behnia and Sean Munro

doi:10.1038/nature04397


Plasma membrane phosphoinositide organization by protein electrostatics p605

Stuart McLaughlin and Diana Murray

doi:10.1038/nature04398


Role of cholesterol and lipid organization in disease p612

Frederick R. Maxfield and Ira Tabas

doi:10.1038/nature04399



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Articles

Phyllosilicates on Mars and implications for early martian climate p623

F. Poulet, J.-P. Bibring, J. F. Mustard, A. Gendrin, N. Mangold, Y. Langevin, R. E. Arvidson, B. Gondet and C. Gomez and The Omega Team

doi:10.1038/nature04274

See also: Editor's summary | News and Views by Newsom


An assembly landscape for the 30S ribosomal subunit p628

Megan W. T. Talkington, Gary Siuzdak and James R. Williamson

doi:10.1038/nature04261

See also: Editor's summary | News and Views by Woodson


Lipid–protein interactions in double-layered two-dimensional AQP0 crystals p633

Tamir Gonen, Yifan Cheng, Piotr Sliz, Yoko Hiroaki, Yoshinori Fujiyoshi, Stephen C. Harrison and Thomas Walz

doi:10.1038/nature04321

See also: Editor's summary | News and Views by Lee


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Letters

Creation of a six-atom 'Schrödinger cat' state p639

D. Leibfried, E. Knill, S. Seidelin, J. Britton, R. B. Blakestad, J. Chiaverini, D. B. Hume, W. M. Itano, J. D. Jost, C. Langer, R. Ozeri, R. Reichle and D. J. Wineland

doi:10.1038/nature04251

See also: Editor's summary


Scalable multiparticle entanglement of trapped ions p643

H. Häffner, W. Hänsel, C. F. Roos, J. Benhelm, D. Chek-al-kar, M. Chwalla, T. Körber, U. D. Rapol, M. Riebe, P. O. Schmidt, C. Becher, O. Gühne, W. Dür and R. Blatt

doi:10.1038/nature04279

See also: Editor's summary


Origin of the metallic properties of heavily boron-doped superconducting diamond p647

T. Yokoya, T. Nakamura, T. Matsushita, T. Muro, Y. Takano, M. Nagao, T. Takenouchi, H. Kawarada and T. Oguchi

doi:10.1038/nature04278

See also: Editor's summary


Chemically tailorable colloidal particles from infinite coordination polymers p651

Moonhyun Oh and Chad A. Mirkin

doi:10.1038/nature04191

See also: Editor's summary


Slowing of the Atlantic meridional overturning circulation at 25° N p655

Harry L. Bryden, Hannah R. Longworth and Stuart A. Cunningham

doi:10.1038/nature04385

See also: Editor's summary | News and Views by Quadfasel


Density dependence explains tree species abundance and diversity in tropical forests p658

Igor Volkov, Jayanth R. Banavar, Fangliang He, Stephen P. Hubbell and Amos Maritan

doi:10.1038/nature04030


Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice p662

Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, Julie A. Ellison, Eric E. Schadt, Inder M. Verma, David J. Lockhart and Carrolee Barlow

doi:10.1038/nature04250

See also: Editor's summary


Risk of severe asthma episodes predicted from fluctuation analysis of airway function p667

Urs Frey, Tanja Brodbeck, Arnab Majumdar, D. Robin Taylor, G. Ian Town, Michael Silverman and Béla Suki

doi:10.1038/nature04176

See also: Editor's summary


The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development p671

Eran Hornstein, Jennifer H. Mansfield, Soraya Yekta, Jimmy Kuang-Hsien Hu, Brian D. Harfe, Michael T. McManus, Scott Baskerville, David P. Bartel and Clifford J. Tabin

doi:10.1038/nature04138

See also: Editor's summary


Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission p675

Jennifer L. Gallop, P. Jonathan G. Butler and Harvey T. McMahon

doi:10.1038/nature04136


Global analysis of protein phosphorylation in yeast p679

Jason Ptacek, Geeta Devgan, Gregory Michaud, Heng Zhu, Xiaowei Zhu, Joseph Fasolo, Hong Guo, Ghil Jona, Ashton Breitkreutz, Richelle Sopko, Rhonda R. McCartney, Martin C. Schmidt, Najma Rachidi, Soo-Jung Lee, Angie S. Mah, Lihao Meng, Michael J. R. Stark, David F. Stern, Claudio De Virgilio, Mike Tyers, Brenda Andrews, Mark Gerstein, Barry Schweitzer, Paul F. Predki and Michael Snyder

doi:10.1038/nature04187

See also: Editor's summary


Silencing of microRNAs in vivo with 'antagomirs' p685

Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan and Markus Stoffel

doi:10.1038/nature04303

See also: Editor's summary


The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression p690

Andrew S. Turnell, Grant S. Stewart, Roger J. A. Grand, Susan M. Rookes, Ashley Martin, Hiroyuki Yamano, Stephen J. Elledge and Phillip H. Gallimore

doi:10.1038/nature04151


Erratum: Astronomical pacing of methane release in the Early Jurassic period p696

David B. Kemp, Angela L. Coe, Anthony S. Cohen and Lorenz Schwark

doi:10.1038/nature04361


Corrigendum: A network-based analysis of systemic inflammation in humans p696

Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkins and Stephen F. Lowry and The Inflammation and Host Response to Injury Large Scale Collaborative Research Program

doi:10.1038/nature04362


Corrigendum: DNA sequence and analysis of human chromosome 18 p696

Chad Nusbaum, Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Keith O'Neill, Bruno Piqani, Cherylyn L. Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakaki and Eric S. Lander

doi:10.1038/nature04363


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Technology Features

Cell biology: Ion channels and stem cells p699

Ion channels, stem cells and cell signalling are the focus of intense interest in both cell biology and drug discovery. Pete Moore takes a look at what's on offer for the researcher.

Pete Moore

doi:10.1038/438699a


Cell biology: Maximizing return p699

doi:10.1038/438699b


Cell biology: Stem-cell options p700

doi:10.1038/438700a


Cell biology: Banking on stem cells p701

doi:10.1038/438701a


Cell biology: Signals of disease p702

doi:10.1038/438702a


Cell biology: Table of suppliers p703

doi:10.1038/438703a


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Naturejobs

Prospect

Physics in crisis? p705

The falling number of physicists in England and Wales needs to be addressed.

Paul Smaglik

doi:10.1038/nj7068-705a


Careers and Recruitment

Thinking outside the cell p706

New tools and technologies are allowing cell biologists to take a more holistic view. To make the most of this, they are teaming up with scientists from other fields. Corie Lok reports.

Corie Lok

doi:10.1038/nj7068-706a


Highlights

Highlight: The National Institutes of Health

doi:10.1038/nj0100


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Futures

The Albian message p710

A blast from the past.

Oliver Morton

doi:10.1038/438710a


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