Table of contents
Volume 437 Number 7062 pp1065-1206
Editorials
Every little helps p1065
Novel techniques that could help to make human embryonic stem-cell research morally acceptable will not immediately defuse the ethical debate over the work.
doi: 10.1038/4371065a
An unhealthy practice p1065
Prescription guidelines should not be written by people with financial conflicts of interest.
doi: 10.1038/4371065b
Grand ambition p1066
Germany's coalition government is well placed to reform the country's scientific system.
doi: 10.1038/4371066a
News
Cash interests taint drug advice p1070
Nature exposes close ties between scientists and manufacturers.
Rosie Taylor and Jim Giles
doi: 10.1038/4371070a
Full Text | PDF (261K) | Supplementary information (27K)
Express delivery to Venus p1071
Europe readies its first mission to Earth's neighbour.
Tony Reichhardt
doi: 10.1038/4371071a
Quake aid hampered by ban on web shots p1072
Open-access satellite images are revolutionizing responses to disasters. Yet the government of Pakistan has forced aid agencies to remove pictures of earthquake devastation from the Internet.
Declan Butler
doi: 10.1038/4371072a
Biologists forced to reassess embryo test p1075
Screening technique for genetic abnormalities under scrutiny.
Erika Check
doi: 10.1038/4371075a
China launches plans for space exploration as taikonauts touch down p1075
Safe landing and heroes welcome after five-day trip in space.
Mark Peplow and Tony Reichhardt
doi: 10.1038/4371075b
'Ethical' routes to stem cells highlight political divide p1076
Novel methods seek to avoid destruction of viable embryos.
Carina Dennis and Erika Check
doi: 10.1038/4371072b
See also: Editor's summary
Sidelines p1076
doi: 10.1038/4371076a
Korea launches network to share cloning information p1077
Government sets up international hub for stem-cell technology.
Carina Dennis
doi: 10.1038/4371077a
News in brief p1078
doi: 10.1038/4371078a
Corrections p1079
doi: 10.1038/4371079a
Clarification p1079
doi: 10.1038/4371079b
News Features
Astrobiology: Life at the cutting edge p1080
Biologists, planetary scientists and engineers have gathered in southern Spain to test a robotic drill. They hope some day to probe for life beneath the surface of Mars. Jenny Hogan investigates.
doi: 10.1038/4371080a
Human genome: Patchwork people p1084
For years it was assumed that tiny differences in our genetic make-up gave us our individual traits. Now it seems that those characteristics are caused by rearrangements of large chunks of our DNA — variations that could be the key to understanding disease. Erika Check investigates.
doi: 10.1038/4371084a
See also: Editor's summary
Business
Venture capitalists tackle Chinese hurdles p1087
David Cyranoski
doi: 10.1038/4371087a
In brief p1087
doi: 10.1038/4371087b
Correspondence
Don't underestimate the death rate from Chernobyl p1089
Timothy A. Mousseau, Neal Nelson and V. Shestopalov
doi: 10.1038/4371089a
Media reports: call for a working party is unrealistic p1089
Jonathan Cowie
doi: 10.1038/4371089b
Main effect of bureaucracy is to reduce productivity p1089
Stephen Moss
doi: 10.1038/4371089c
Concern at animal research should not be dismissed p1089
Jacqueline Zupp
doi: 10.1038/4371089d
Books and Arts
Oppenheimer: the opera p1091
A musical treatment of the development of the atomic bomb raises questions still relevant today.
Philip Campbell reviews Doctor Atomic composed by John Adams, directed by Peter Sellars. San Francisco Opera world premiere, 1 October 2005
doi: 10.1038/4371091a
See also: Editor's summary
Mathematical musings p1092
Timothy Gowers reviews Euclid in the Rainforest: Discovering Universal Truth in Logic and Math by Joseph Mazur
doi: 10.1038/4371092a
Up close and colourful p1092
doi: 10.1038/4371092b
Mixed reactions p1093
Pierluigi Nicotera reviews The Poison Paradox: Chemicals as Friends and Foes by John Timbrell
doi: 10.1038/4371093a
Essay
An explorer and surveyor p1095
Hermann Weyl made prescient contributions to both mathematics and physics, but also strove to understand reality as a whole.
Frank Wilczek
doi: 10.1038/4371095a
News and Views
Molecular biology: DNA twists and flips p1097
DNA can shape itself into many forms to achieve its purposes in life. The crystal structure of the junction between two of its forms provides insight into how DNA might accomplish some of these acrobatics.
Richard R. Sinden
doi: 10.1038/4371097a
See also: Editor's summary
Catalysis: Gold rush p1098
The chemical industry would be transformed if selective oxidation of hydrocarbons could be achieved efficiently using cheap and clean oxygen from the air. Doing that with gold as a catalyst is a method gaining in allure.
Masatake Haruta
doi: 10.1038/4371098a
See also: Editor's summary
Evolution: Along came a sea spider p1099
An investigation of brain development in sea spiders provides hints about how the earliest arthropod head evolved. These observations are bound to provoke controversy in an already acrimonious field.
Graham E. Budd and Maximilian J. Telford
doi: 10.1038/4371099a
See also: Editor's summary
50 & 100 years ago p1101
doi: 10.1038/4371101a
Quantum physics: Atom waves in passing p1102
Matter-wave interferometers are unique tools for exposing particles acting like waves — one of the stranger facets of quantum theory. They can even measure the quickening of an atom's 'pulse' as it flies past a surface.
Maarten DeKieviet and Joerg Schmiedmayer
doi: 10.1038/4371102a
Cell biology: A BID for the pathway p1103
Cells have many ways of coping with damage to their DNA, but how are these all coordinated? It seems that BID — a regulator of programmed cell death — stands at the crossroads of several damage-response pathways.
Michael B. Kastan
doi: 10.1038/4371103a
Astronomy: Odd company p1105
Black holes cannot yet be seen directly, but their influence on surrounding stars is allowing them to be identified with increasing certainty. That those stars are there to be influenced, though, raises other questions.
Fulvio Melia
doi: 10.1038/4371105a
Evolutionary biology: Fruitfly genome is not junk p1106
A comparison of two fruitfly genomes shows that much of their non-coding DNA is controlled by either negative or positive selection, dealing a double blow to the neutral theory of molecular evolution.
Alexey S. Kondrashov
doi: 10.1038/4371106a
See also: Editor's summary
Brief Communications
Intercepting the first rat ashore p1107
Keeping islands free of rats may be harder with isolated invaders as these evade conventional trapping.
James C. Russell, David R. Towns, Sandra H. Anderson and Mick N. Clout
doi: 10.1038/4371107a
First paragraph | Full Text | PDF (169K) | Supplementary information
Avian flu: Isolation of drug-resistant H5N1 virus p1108
Q. Mai Le, Maki Kiso, Kazuhiko Someya, Yuko T. Sakai, T. Hien Nguyen, Khan H. L. Nguyen, N. Dinh Pham, Ha H. Ngyen, Shinya Yamada, Yukiko Muramoto, Taisuke Horimoto, Ayato Takada, Hideo Goto, Takashi Suzuki, Yasuo Suzuki and Yoshihiro Kawaoka
doi: 10.1038/4371108a
First paragraph | Full Text | PDF (167K) | Supplementary information
See also: Editor's summary
Articles
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism p1109
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A. Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle, Hiroshi Takemori and Marc Montminy
doi: 10.1038/nature03967
Abstract | Full Text | PDF (472K) | Supplementary information
See also: Editor's summary
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines p1115
Andreas Martin, Tania A. Baker and Robert T. Sauer
doi: 10.1038/nature04031
Abstract | Full Text | PDF (412K)
See also: Editor's summary | Authors
Letters
A 'dry' condensation origin for circumstellar carbonates p1121
Alice Toppani, François Robert, Guy Libourel, Philippe de Donato, Odile Barres, Louis d'Hendecourt and Jaafar Ghanbaja
doi: 10.1038/nature04128
First paragraph | Full Text | PDF (348K) | Supplementary information
See also: Editor's summary
Secondary craters on Europa and implications for cratered surfaces p1125
Edward B. Bierhaus, Clark R. Chapman and William J. Merline
doi: 10.1038/nature04069
First paragraph | Full Text | PDF (190K)
See also: Editor's summary | Authors
Enhancing semiconductor device performance using ordered dopant arrays p1128
Takahiro Shinada, Shintaro Okamoto, Takahiro Kobayashi and Iwao Ohdomari
doi: 10.1038/nature04086
First paragraph | Full Text | PDF (300K)
See also: Editor's summary
Tunable gold catalysts for selective hydrocarbon oxidation under mild conditions p1132
Mathew D. Hughes, Yi-Jun Xu, Patrick Jenkins, Paul McMorn, Philip Landon, Dan I. Enache, Albert F. Carley, Gary A. Attard, Graham J. Hutchings, Frank King, E. Hugh Stitt, Peter Johnston, Ken Griffin and Christopher J. Kiely
doi: 10.1038/nature04190
First paragraph | Full Text | PDF (260K) | Supplementary information
See also: Editor's summary
Thermochemical structures beneath Africa and the Pacific Ocean p1136
Allen K. McNamara and Shijie Zhong
doi: 10.1038/nature04066
First paragraph | Full Text | PDF (2,400K)
Helium solubility in olivine and implications for high 3He/4He in ocean island basalts p1140
Stephen W. Parman, Mark D. Kurz, Stanley R. Hart and Timothy L. Grove
doi: 10.1038/nature04215
First paragraph | Full Text | PDF (249K) | Supplementary information
Neuroanatomy of sea spiders implies an appendicular origin of the protocerebral segment p1144
Amy Maxmen, William E. Browne, Mark Q. Martindale and Gonzalo Giribet
doi: 10.1038/nature03984
First paragraph | Full Text | PDF (306K) | Supplementary information
See also: Editor's summary
Adaptive evolution of non-coding DNA in Drosophila p1149
Peter Andolfatto
doi: 10.1038/nature04107
First paragraph | Full Text | PDF (201K) | Supplementary information
See also: Editor's summary
Natural selection on protein-coding genes in the human genome p1153
Carlos D. Bustamante, Adi Fledel-Alon, Scott Williamson, Rasmus Nielsen, Melissa Todd Hubisz, Stephen Glanowski, David M. Tanenbaum, Thomas J. White, John J. Sninsky, Ryan D. Hernandez, Daniel Civello, Mark D. Adams, Michele Cargill and Andrew G. Clark
doi: 10.1038/nature04240
First paragraph | Full Text | PDF (777K) | Supplementary information
See also: Editor's summary
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories p1158
Terra D. Barnes, Yasuo Kubota, Dan Hu, Dezhe Z. Jin and Ann M. Graybiel
doi: 10.1038/nature04053
First paragraph | Full Text | PDF (412K) | Supplementary information
See also: Editor's summary
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution p1162
Elodie Ghedin, Naomi A. Sengamalay, Martin Shumway, Jennifer Zaborsky, Tamara Feldblyum, Vik Subbu, David J. Spiro, Jeff Sitz, Hean Koo, Pavel Bolotov, Dmitry Dernovoy, Tatiana Tatusova, Yiming Bao, Kirsten St George, Jill Taylor, David J. Lipman, Claire M. Fraser, Jeffery K. Taubenberger and Steven L. Salzberg
doi: 10.1038/nature04239
First paragraph | Full Text | PDF (351K) | Supplementary information
See also: Editor's summary
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus p1167
Etienne Meylan, Joseph Curran, Kay Hofmann, Darius Moradpour, Marco Binder, Ralf Bartenschlager and Jürg Tschopp
doi: 10.1038/nature04193
First paragraph | Full Text | PDF (746K) | Supplementary information
Towards a proteome-scale map of the human protein–protein interaction network p1173
Jean-François Rual, Kavitha Venkatesan, Tong Hao, Tomoko Hirozane-Kishikawa, Amélie Dricot, Ning Li, Gabriel F. Berriz, Francis D. Gibbons, Matija Dreze, Nono Ayivi-Guedehoussou, Niels Klitgord, Christophe Simon, Mike Boxem, Stuart Milstein, Jennifer Rosenberg, Debra S. Goldberg, Lan V. Zhang, Sharyl L. Wong, Giovanni Franklin, Siming Li, Joanna S. Albala, Janghoo Lim, Carlene Fraughton, Estelle Llamosas, Sebiha Cevik, Camille Bex, Philippe Lamesch, Robert S. Sikorski, Jean Vandenhaute, Huda Y. Zoghbi, Alex Smolyar, Stephanie Bosak, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael E. Cusick, David E. Hill, Frederick P. Roth and Marc Vidal
doi: 10.1038/nature04209
First paragraph | Full Text | PDF (1,712K) | Supplementary information
Photosystem II core phosphorylation and photosynthetic acclimation require two different protein kinases p1179
Vera Bonardi, Paolo Pesaresi, Thomas Becker, Enrico Schleiff, Raik Wagner, Thomas Pfannschmidt, Peter Jahns and Dario Leister
doi: 10.1038/nature04016
First paragraph | Full Text | PDF (323K) | Supplementary information
Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases p1183
Sung Chul Ha, Ky Lowenhaupt, Alexander Rich, Yang-Gyun Kim and Kyeong Kyu Kim
doi: 10.1038/nature04088
First paragraph | Full Text | PDF (405K) | Supplementary information
See also: Editor's summary | Authors
Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover p1187
Anastasia J. Callaghan, Maria Jose Marcaida, Jonathan A. Stead, Kenneth J. McDowall, William G. Scott and Ben F. Luisi
doi: 10.1038/nature04084
First paragraph | Full Text | PDF (384K) | Supplementary information
Technology Features
DNA microarrays: More than gene expression p1195
DNA microarrays are diversifying in new directions, including in vitro diagnostics. Diane Gershon takes a look at what's around the corner for microarray applications.
Diane Gershon
doi: 10.1038/4371195a
See also: Editor's summary
DNA microarrays: It's a small world p1195
doi: 10.1038/4371195b
DNA microarrays: Microarrays move downstream p1196
doi: 10.1038/4371196a
DNA microarrays: On the hardware front p1198
doi: 10.1038/4371198a
Table of suppliers p1199
doi: 10.1038/4371199a
Naturejobs
ProspectThe path to success p1201
EMBO award winner points to good working environment as secret to his success.
Paul Smaglik
doi:10.1038/nj7062-1201a
Career Views
You say genomics, I say genetics... p1202
Whatever title is afforded today's practitioners of molecular genetics, one thing is certain — success hinges on having a wide set of skills. Ricki Lewis reports.
Ricki Lewis
doi:10.1038/nj7062-1202a
David Bentley, chief scientist, Solexa, Chesterford, UK p1204
Key early encounters fuels biotech career.
Corie Lok
doi:10.1038/nj7062-1204a
Scientists & Societies p1204
German organization aims to bring young scientists out of isolation.
Ulrich Schollwöck
doi:10.1038/nj7062-1204b
Graduate Journal: Eye-opening meeting p1204
Poster session leads to networking opportunities.
Karolina Tkaczuk
doi:10.1038/nj7062-1204c
