Supplementary information
From the following article:
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Chrysiis Michaloglou, Liesbeth C. W. Vredeveld, Maria S. Soengas, Christophe Denoyelle, Thomas Kuilman, Chantal M. A. M. van der Horst, Donné M. Majoor, Jerry W. Shay, Wolter J. Mooi & Daniel S. Peeper
Nature 436, 720-724(4 August 2005)
doi:10.1038/nature03890
Supplmentary Figure S1
Ectopic overexpression of BRAFE600 causes a senescence-like cell cycle arrest.
Supplmentary Figure S2a-f
Physiologic levels of BRAFE600 induce senescence in a p16INK4a-independent manner.
Supplementary Figure 2g-l
Physiologic levels of BRAFE600 induce senescence in a p16INK4a-independent manner.
Supplmentary Figure S3
BRAFE600 fails to induce p14ARF.
Supplementary Figure S4
Sustained knockdown of p16INK4a cause an increase in cellular proliferation rate
Supplementary Figure S5
BRAFE600 mutational analysis in human congenital nevi.
Supplementary Figure S6
Mosaic pattern of p16INK4a-positivity in nevi.
Supplementary Figure S7
No apparent telomere loss in nevi.
Supplementary Figure Legends
Text to accompany the above Supplementary Figures.
Supplementary Methods
Additional descriptions of methods used in this study, to accompany those detailed in the main text.
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