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Supplementary information

From the following article:

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher and William R. Sellers

Nature 436, 117-122(7 July 2005)

doi:10.1038/nature03664

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Supplementary Figure S1

Full cluster-ordered data set of NCI60 samples and SNPs (derived from CentXbaTM array data).

Supplementary Figure S2

Melanoma tissue array clinical parameters-I: age, gender, and anatomic location of tumour.

Supplementary Figure S3

Melanoma tissue array clinical parameters -II: Clark level, Breslow depth, and immune response.

Supplementary Figure S4

Expression of dominant-negative MITF following adenoviral infection.

Supplementary Figure S5

Pharmacologic analysis of NCI60 cell lines with and without copy gain at the MITF (3p) locus.

Supplementary Figure Legends

Legends to accompany Supplementary Figures.

Supplementary Methods

This file contains additional SNP array descriptions, methods, and references.

Supplementary Table S1

Primer sequences used for quantitative and allele-specific PCR.

Supplementary Table S2

3p14 dosage, BRAF(V600E) mutation, and CDKN2A (p16) status in NCI60 melanoma cell lines.

Supplementary Table S3

MITF copy number distribution on the melanoma tissue microarray.

Supplementary Notes

MIAME Checklist

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