Table of contents


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Editorial

Disease insights from stem cells p787

Confronted by religious and political opposition, proponents of embryonic-stem-cell research need to draw attention not only to new therapies but also to the understanding of diseases that they could soon yield.

doi:10.1038/422787a


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News

Historians pool resources to halt trade in Iraq's stolen treasures p789

Hannah Hoag

doi:10.1038/422789a


US debates future of Iraqi scientists p789

Erika Check

doi:10.1038/422789b


India pledges deluge of funds to water plan p790

K. S. Jayaraman

doi:10.1038/422790a


Biotech firms pin hopes on defence p790

Helen Pearson

doi:10.1038/422790b


Biologists deploy database to quash drug-resistant bacteria p791

Tom Clarke

doi:10.1038/422791a


National Academies launch grants for interdisciplinary work p791

Erika Check

doi:10.1038/422791b


University faces up to wartime use of slaves p792

Alison Abbott

doi:10.1038/422792a


Atlantic cod meet icy death p792

Hannah Hoag

doi:10.1038/422792b


Lie probes to continue at US weapons labs p793

Geoff Brumfiel

doi:10.1038/422793a


Agent Orange health investigation stuck at square one p793

Declan Butler

doi:10.1038/422793b


news in brief p794

doi:10.1038/422794a


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news feature

Rice genome: A recipe for revolution? p796

Sequencing the DNA of the world's leading food crop was the easy part. Now comes the tricky task of turning our new knowledge of the rice genome into agricultural and economic gains. David Cyranoski reports.

David Cyranoski

doi:10.1038/422796a


The Grid: Tomorrow's computing today p799

The physics lab that gave us the World Wide Web is now gearing up to make the first practical deployment of the Internet's next big thing: the Grid. Declan Butler takes a test drive.

Declan Butler

doi:10.1038/422799a


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Correspondence

Unrestricted free access works and must continue p801

Bioinformatics researchers shouldn't need coercion to act responsibly and collegially.

Steven Salzberg, Ewan Birney, Sean Eddy and Owen White

doi:10.1038/422801a


Watching an IT icon slide into history p801

W. John Cram

doi:10.1038/422801b


Secrecy is increasing in step with competition p801

John P. Walsh and Wei Hong

doi:10.1038/422801c


Pre-genomics training hinders Indian biotech p802

R. M. Ranganath

doi:10.1038/422802a


Should tobacco ban rule out governments too? p802

Richard S. Jope

doi:10.1038/422802b


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Commentaries

Who cares about the double helix? p803

Collective memory links the past to the future in science as well as history.

doi:10.1038/422803a


DNA from Alberts to Zinder p806

doi:10.1038/422806a


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BA_SB

Life, the movie p809

Fifty years after revealing the structure of DNA, James Watson looks back.

Maxine Singer reviews DNA: The Secret of Life by James D. Watson, Andrew Berry and Alfred A. Knopf

doi:10.1038/422809a


A final call for peace p810

David Hull reviews The Hedgehog, the Fox, and the Magister's Pox: Mending the Gap Between Science and the Humanities by Stephen Jay Gould

doi:10.1038/422810a


Einstein's view of Germany p811

Freeman J. Dyson reviews Einstein in Berlin by Thomas Levenson

doi:10.1038/422811a


Getting heated over glaciation p812

Euan Nisbet reviews Snowball Earth by Gabrielle Walker

doi:10.1038/422812a


Gould and God p813

Jerry A. Coyne reviews A Devil's Chaplain by Richard Dawkins

doi:10.1038/422813a


The writing on the slate p814

Andrew Berry reviews Nature via Nurture: Genes, Experience and What Makes Us Human by Matt Ridley

doi:10.1038/422814a


The evolutionary blackbird p815

Carl Zimmer reviews The Story of Life by Richard Southwood

doi:10.1038/422815a


Metabolic gardening p816

E. C. Slater reviews Wandering in the Gardens of the Mind: Peter Mitchell and the Making of Glynn by John Prebble and Bruce Weber

doi:10.1038/422816a


History in the making p816

doi:10.1038/422816b


Science in culture p817

Lynn Gamwell reviews

doi:10.1038/422817a


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Lifeline

Seeking connections: H. Eugene Stanley p819

doi:10.1038/422819a


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News and Views

Genome sequencing: Revelations from a bread mould p821

The filamentous fungus Neurospora crassa is an organism much loved by geneticists. Its genome sequence has now been unveiled, and includes some surprises — such as the relatively high number of genes.

Jonathan Arnold and Nelson Hilton

doi:10.1038/422821a


Quantum electronics: The electron is cool p822

Temperature is an awkward concept for a single particle, but the energy of the particle's 'quivering' is a useful substitute. Feedback control of this motion can be used to cool a single electron to very low temperature.

Peter E. Toschek

doi:10.1038/422822a


Stem cells: Fusion brings down barriers p823

It remains uncertain how tissue-specific stem cells could generate the mature cell types of another tissue. In one instance, where bone-marrow-derived stem cells repair damaged liver in mice, cell fusion is the answer.

Alexander Medvinsky and Austin Smith

doi:10.1038/422823a


Astronomy: Telling the tale of the first stars p825

HE0107–5240 is a star in more than one sense of the word. Chemically, it is the most primitive object yet discovered, and it is at the centre of debate about the origins of the first elements in the Universe.

Timothy C. Beers

doi:10.1038/422825a


Ecology: A liverwort cheat p826

Tim Lincoln

doi:10.1038/422826a


Cancer: Escape from inhibition p827

Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.

Sara A. Courtneidge

doi:10.1038/422827a


100 and 50 years ago p827

doi:10.1038/422827b


news and view in brief p829

doi:10.1038/422829a


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Brief Communications

Aetiology: The earliest recorded plant virus disease p831

Pathogenic DNA paints summer foliage gold, and inspired a poet over a millennium ago.

Keith Saunders, Ian D. Bedford, Tetsukazu Yahara and John Stanley

doi:10.1038/422831a


Nutritional biochemistry: A new redox-cofactor vitamin for mammals p832

Takaoki Kasahara and Tadafumi Kato

doi:10.1038/422832a


Evolutionary biology (communication arising): Why do birds engage in extra-pair copulation? p833

Simon C. Griffith and Robert Montgomerie

doi:10.1038/422833a


Evolutionary biology (communication arising): Why do birds engage in extra-pair copulation? p833

Donald Blomqvist, Malte Andersson, Clemens Küpper, Innes C. Cuthill, János Kis, Richard B. Lanctot, Brett K. Sandercock, Tamás Székely, Johan Wallander and Bart Kempenaers

doi:10.1038/422833b


Astrophysics: How did the metals in a giant star originate? p834

Piercarlo Bonifacio, Marco Limongi and Alessandro Chieffi

doi:10.1038/422834a


addendum: Adult persistence of head-turning asymmetry p834

O. Güntürkün

doi:10.1038/422834b


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Feature

A vision for the future of genomics research p835

A blueprint for the genomic era.

Francis S. Collins, Eric D. Green, Alan E. Guttmacher and Mark S. Guyer


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Review

Genetics and the making of Homo sapiens p849

Sean B. Carroll

doi:10.1038/nature01495


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Article

The genome sequence of the filamentous fungus Neurospora crassa p859

James E. Galagan, Sarah E. Calvo, Katherine A. Borkovich, Eric U. Selker, Nick D. Read, David Jaffe, William FitzHugh, Li-Jun Ma, Serge Smirnov, Seth Purcell, Bushra Rehman, Timothy Elkins, Reinhard Engels, Shunguang Wang, Cydney B. Nielsen, Jonathan Butler, Matthew Endrizzi, Dayong Qui, Peter Ianakiev, Deborah Bell-Pedersen, Mary Anne Nelson, Margaret Werner-Washburne, Claude P. Selitrennikoff, John A. Kinsey, Edward L. Braun, Alex Zelter, Ulrich Schulte, Gregory O. Kothe, Gregory Jedd, Werner Mewes, Chuck Staben, Edward Marcotte, David Greenberg, Alice Roy, Karen Foley, Jerome Naylor, Nicole Stange-Thomann, Robert Barrett, Sante Gnerre, Michael Kamal, Manolis Kamvysselis, Evan Mauceli, Cord Bielke, Stephen Rudd, Dmitrij Frishman, Svetlana Krystofova, Carolyn Rasmussen, Robert L. Metzenberg, David D. Perkins, Scott Kroken, Carlo Cogoni, Giuseppe Macino, David Catcheside, Weixi Li, Robert J. Pratt, Stephen A. Osmani, Colin P. C. DeSouza, Louise Glass, Marc J. Orbach, J. Andrew Berglund, Rodger Voelker, Oded Yarden, Michael Plamann, Stephan Seiler, Jay Dunlap, Alan Radford, Rodolfo Aramayo, Donald O. Natvig, Lisa A. Alex, Gertrud Mannhaupt, Daniel J. Ebbole, Michael Freitag, Ian Paulsen, Matthew S. Sachs, Eric S. Lander, Chad Nusbaum and Bruce Birren

doi:10.1038/nature01554

See also: News and Views by Arnold & Hilton


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Letters to Nature

Low-mass relics of early star formation p869

R. Schneider, A. Ferrara, R. Salvaterra, K. Omukai and V. Bromm

doi:10.1038/nature01579


First-generation black-hole-forming supernovae and the metal abundance pattern of a very iron-poor star p871

Hideyuki Umeda and Ken'ichi Nomoto

doi:10.1038/nature01571


No mixing of superconductivity and antiferromagnetism in a high-temperature superconductor p873

I. Bozovic, G. Logvenov, M. A. J. Verhoeven, P. Caputo, E. Goldobin and T. H. Geballe

doi:10.1038/nature01544


Experimental detection of alpha-particles from the radioactive decay of natural bismuth p876

Pierre de Marcillac, Noël Coron, Gérard Dambier, Jacques Leblanc and Jean-Pierre Moalic

doi:10.1038/nature01541


Magmatic events can produce rapid changes in hydrothermal vent chemistry p878

Marvin D. Lilley, David A. Butterfield, John E. Lupton and Eric J. Olson


A test of the unified neutral theory of biodiversity p881

Brian J. McGill

doi:10.1038/nature01583


Ecological interference between fatal diseases p885

P. Rohani, C. J. Green, N. B. Mantilla-Beniers and B. T. Grenfell

doi:10.1038/nature01542


Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing p888

Shuang-Xi Ren, Gang Fu, Xiu-Gao Jiang, Rong Zeng, You-Gang Miao, Hai Xu, Yi-Xuan Zhang, Hui Xiong, Gang Lu, Ling-Feng Lu, Hong-Quan Jiang, Jia Jia, Yue-Feng Tu, Ju-Xing Jiang, Wen-Yi Gu, Yue-Qing Zhang, Zhen Cai, Hai-Hui Sheng, Hai-Feng Yin, Yi Zhang, Gen-Feng Zhu, Ma Wan, Hong-Lei Huang, Zhen Qian, Sheng-Yue Wang, Wei Ma, Zhi-Jian Yao, Yan Shen, Bo-Qin Qiang, Qi-Chang Xia, Xiao-Kui Guo, Antoine Danchin, Isabelle Saint Girons, Ronald L. Somerville, Yu-Mei Wen, Man-Hua Shi, Zhu Chen, Jian-Guo Xu and Guo-Ping Zhao

doi:10.1038/nature01597


The methylated component of the Neurospora crassa genome p893

Eric U. Selker, Nikolaos A. Tountas, Sally H. Cross, Brian S. Margolin, Jonathan G. Murphy, Adrian P. Bird and Michael Freitag

doi:10.1038/nature01564


Cell fusion is the principal source of bone-marrow-derived hepatocytes p897

Xin Wang, Holger Willenbring, Yassmine Akkari, Yumi Torimaru, Mark Foster, Muhsen Al-Dhalimy, Eric Lagasse, Milton Finegold, Susan Olson and Markus Grompe

doi:10.1038/nature01531

See also: News and Views by Medvinsky & Smith


Transplanted bone marrow regenerates liver by cell fusion p901

George Vassilopoulos, Pei-Rong Wang and David W. Russell

doi:10.1038/nature01539

See also: News and Views by Medvinsky & Smith


Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway p905

Ken-Ichi Takemaru, Shinji Yamaguchi, Young Sik Lee, Yang Zhang, Richard W. Carthew and Randall T. Moon

doi:10.1038/nature01570


DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing p909

Alexander Saveliev, Christopher Everett, Tammy Sharpe, Zoë Webster and Richard Festenstein

doi:10.1038/nature01596


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Technology Features

Pharmacogenetics and Genotyping: On the trail of SNPs p917

Extracting useful data from the human genome sequence is a major challenge. Lisa Melton examines the early steps towards personal genotyping.

Lisa Melton

doi:10.1038/422917a


Crime busters p917

doi:10.1038/422917b


Risk assessment p919

doi:10.1038/422919a


Haplotypes of pools? p921

doi:10.1038/422921a


table of suppliers p924

doi:10.1038/422924a


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Naturejobs

Prospects

Beyond the helix p927

Paul Smaglik

doi:10.1038/nj6934-927a


SPECIAL REPORT

Stem-cell research p928

Complex political, ethical and legal issues surround research on human embryonic stem cells. Diane Gershon explores the field's long-term career prospects.

Diane Gershon

doi:10.1038/nj6934-928a


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