Naturejobs

Another British invasion? p3

Paul Smaglik

doi:10.1038/nj6916-03a

Full Text | PDF (71K)

Fresh horizons South Korea p4

David Cyranoski

doi:10.1038/nj6916-04a

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Opinion

Prioritizing Australia p591

Australia's researchers have been set national goals by their government. The underlying agenda is to ensure that the country's institutions spend scarce funds more wisely and in a way that reflects joined-up thinking.

doi:10.1038/420591a

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Through the protein labyrinth p591

Proteomics is delivering results that pose new problems in data management and compatibility.

doi:10.1038/420591b

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News

NASA roadmap charts route to a quarter-century of exploration p593

Tony Reichhardt

doi:10.1038/420593a

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Canada stops Harvard's oncomouse in its tracks p593

Erika Check

doi:10.1038/420593b

Full Text | PDF (111K)

Paper trail reveals references go unread by citing authors p594

Philip Ball

doi:10.1038/420594a

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Radar array tests the atmosphere at pole position p594

David Cyranoski

doi:10.1038/420594b

Full Text | PDF (43K)

Bush climate-change plan gets cool response p595

Kendall Powell

doi:10.1038/420595a

Full Text | PDF (76K)

Safety panel backs principle of gene-therapy trials p595

Erika Check

doi:10.1038/420595b

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Labs cook up strategy to test transgenic food p596

Alison Abbott

doi:10.1038/420596a

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Syngenta ready to drop plans for Indian rice venture p596

K. S. Jayaraman

doi:10.1038/420596b

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Australia sets priorities for future research p597

Carina Dennis

doi:10.1038/420597a

Full Text | PDF (91K)

Ousted creationist sues over website p597

Geoff Brumfiel

doi:10.1038/420597b

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news in brief p598

doi:10.1038/420598a

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News

Clarification p599

doi:10.1038/420599a

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news feature

Alliance for cellular signaling: Into unknown territory p600

The Alliance for Cellular Signaling is exploring new frontiers, both in fundamental scientific terms and in the way in which research in cell biology is conducted. Alison Abbott reports.

Alison Abbott

doi:10.1038/420600a

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Research materials: Share and share alike? p602

Producing a popular research tool will make you a lot of friends in science. But meeting requests to supply the material puts a heavy burden on your lab. David Cyranoski examines a system under pressure.

David Cyranoski

doi:10.1038/420602a

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Correspondence

Isolationism is not the answer to bioterrorism p605

Increased support for research in the developing world would be a better strategy.

Jerome A. Singh and Peter A. Singer

doi:10.1038/420605a

Full Text | PDF (36K)

Schools can be inspired by a summer of science p605

Rosalia Vargas and Ana Noronha

doi:10.1038/420605b

Full Text | PDF (36K)

What has posterity done for us? It's not the point p605

Ken Caldeira

doi:10.1038/420605c

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What has posterity done for us? It's not the point p605

Lawrence H. Goulder and Robert N. Stavins

doi:10.1038/420605d

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Book Reviews

The conscience of physics p607

The life, work and dreams of Wolfgang Pauli.

Freeman Dyson reviews No Time to be Brief: A Scientific Biography of Wolfgang Pauli by Charles P. Enz

doi:10.1038/420607a

Full Text | PDF (261K)

Through the eyes of God's naturalist p608

Rebecca Stott reviews Glimpses of the Wonderful: The Life of Philip Henry Gosse by Ann Thwaite

doi:10.1038/420608a

Full Text | PDF (205K)

So near, but yet so far p609

Bernard Wood reviews Human Evolution Through Developmental Change by Nancy Minugh-Purvis and Kenneth J. McNamara

doi:10.1038/420609a

Full Text | PDF (53K)

The dance of chance p609

doi:10.1038/420609b

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concepts

Progressive evolution: Aspirational thinking p611

Henry Gee

doi:10.1038/420611a

Full Text | PDF (63K)

News and Views

Structural biology: On the wings of inhibition p613

Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.

Jeffrey L. Wrana

doi:10.1038/420613a

Full Text | PDF (356K)

Nuclear physics: A triple point in nuclei p614

Triple points describe states of matter in which three phases exist at the same time — such as solid, liquid and gas. The same phenomenon has now been found to occur between three different shapes of atomic nuclei.

David Warner

doi:10.1038/420614a

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Aerodynamics: Red admiral agility p615

Our understanding of insect flight is hampered by the difficulty of obtaining data when the insects are flying freely. But such experiments can be carried out and show butterflies to be masters of flight control.

Rafa Zbikowski

doi:10.1038/420615a

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100 and 50 years ago p617

doi:10.1038/420617a

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Planetary science: Seeing double in the Kuiper belt p618

A small fraction of Kuiper-belt objects are known to be accompanied by large moons. These double worlds may have formed in the earliest days of the Solar System through comparatively gentle gravitational encounters.

Daniel D. Durda

doi:10.1038/420618a

Full Text | PDF (191K)

Physiology: Is brain sympathetic to bone? p619

The fat-derived hormone leptin is best known for its effects on weight. But it also influences bone density, and new work reveals a role for the sympathetic nervous system in mediating this effect.

Jeffrey S. Flier

doi:10.1038/420619a

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Biomechanics: Frogs in and out of phase p621

R. McNeill Alexander

doi:10.1038/420621a

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Oceanography: Gas hydrates on the brink p622

Huge amounts of methane are locked up in deposits that lie deep beneath the sea floor. New seismic images reveal that these deposits possess unexpected features that might affect their stability.

Ingo A. Pecher

doi:10.1038/420622a

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HIV: Conformational camouflage p623

A study of the thermodynamics of antibody binding to a crucial HIV protein has shed light on why the virus so effectively evades the antibody arm of the immune response. Changes in the protein's conformation are the key.

Theodore Jardetzky

doi:10.1038/420623a

Full Text | PDF (90K)

Brief Communications

Pollination: Rotting smell of dead-horse arum florets p625

These blooms chemically fool flies into pollinating them.

Marcus C. Stensmyr, Isabella Urru, Ignazio Collu, Malin Celander, Bill S. Hansson and Anna-Maria Angioy

doi:10.1038/420625a

First paragraph | Full Text | PDF (114K)

Ontogenetic growth (Communication arising): Modelling universality and scaling p626

Jayanth R. Banavar, John Damuth, Amos Maritan and Andrea Rinaldo

doi:10.1038/420626a

First paragraph | Full Text | PDF (85K)

Ontogenetic growth (Communication arising): Modelling universality and scaling p626

Geoffrey B. West, Brian J. Enquist and James H. Brown

doi:10.1038/420626b

First paragraph | Full Text | PDF (85K)

Climate change (Communication arising): Regional warming and malaria resurgence p627

Jonathan A. Patz, Mike Hulme, Cynthia Rosenzweig, Timothy D. Mitchell, Richard A. Goldberg, Andrew K. Githeko, Subhash Lele, Anthony J. McMichael and David Le Sueur

doi:10.1038/420627a

First paragraph | Full Text | PDF (55K)

Climate change (Communication arising): Regional warming and malaria resurgence p628

Simon I. Hay, Jonathan Cox, David J. Rogers, Sarah E. Randolph, David I. Stern, G. Dennis Shanks, Monica F. Myers and Robert W. Snow

doi:10.1038/420628a

First paragraph | Full Text | PDF (37K)

Review

Rho GTPases in cell biology p629

Sandrine Etienne-Manneville and Alan Hall

doi:10.1038/nature01148

Abstract | Full Text | PDF (382K)

Article

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin p636

Jay Groppe, Jason Greenwald, Ezra Wiater, Joaquin Rodriguez-Leon, Aris N. Economides, Witek Kwiatkowski, Markus Affolter, Wylie W. Vale, Juan Carlos Izpisua Belmonte and Senyon Choe

doi:10.1038/nature01245

Abstract | Full Text | PDF (579K) | Supplementary information

See also: News and Views by Wrana

Letters to Nature

Formation of Kuiper-belt binaries by dynamical friction and three-body encounters p643

Peter Goldreich, Yoram Lithwick and Re'em Sari

doi:10.1038/nature01227

First paragraph | Full Text | PDF (316K)

See also: News and Views by Durda

Zero-resistance states induced by electromagnetic-wave excitation in GaAs/AlGaAs heterostructures p646

Ramesh G. Mani, Jürgen H. Smet, Klaus von Klitzing, Venkatesh Narayanamurti, William B. Johnson and Vladimir Umansky

doi:10.1038/nature01277

First paragraph | Full Text | PDF (462K)

Wavelength-scalable hollow optical fibres with large photonic bandgaps for CO₂ laser transmission p650

Burak Temelkuran, Shandon D. Hart, Gilles Benoit, John D. Joannopoulos and Yoel Fink

doi:10.1038/nature01275

First paragraph | Full Text | PDF (309K) | Supplementary information

Bond-controlled configurational entropy reduction in chemical vitrification p653

Silvia Corezzi, Daniele Fioretto and Pierangelo Rolla

doi:10.1038/nature01261

First paragraph | Full Text | PDF (203K)

Decreased stability of methane hydrates in marine sediments owing to phase-boundary roughness p656

W. T. Wood, J. F. Gettrust, N. R. Chapman, G. D. Spence and R. D. Hyndman

doi:10.1038/nature01263

First paragraph | Full Text | PDF (582K)

See also: News and Views by Pecher

Unconventional lift-generating mechanisms in free-flying butterflies p660

R. B. Srygley and A. L. R. Thomas

doi:10.1038/nature01223

First paragraph | Full Text | PDF (471K) | Supplementary information

See also: News and Views by Zbikowski

Sex releases the speed limit on evolution p664

Nick Colegrave

doi:10.1038/nature01191

First paragraph | Full Text | PDF (155K)

Large clusters of co-expressed genes in the Drosophila genome p666

Alexander M. Boutanaev, Alla I. Kalmykova, Yuri Y. Shevelyov and Dmitry I. Nurminsky

doi:10.1038/nature01216

First paragraph | Full Text | PDF (178K) | Supplementary information

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel p669

Dattananda S. Chelur, Glen G. Ernstrom, Miriam B. Goodman, C. Andrea Yao, Lei Chen, Robert O' Hagan and Martin Chalfie

doi:10.1038/nature01205

First paragraph | Full Text | PDF (316K) | Supplementary information

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime p673

Hyuk Wan Ko, Jin Jiang and Isaac Edery

doi:10.1038/nature01272

First paragraph | Full Text | PDF (595K) | Supplementary information

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites p678

Peter D. Kwong, Michael L. Doyle, David J. Casper, Claudia Cicala, Stephanie A. Leavitt, Shahzad Majeed, Tavis D. Steenbeke, Miro Venturi, Irwin Chaiken, Michael Fung, Hermann Katinger, Paul W. I. H. Parren, James Robinson, Donald Van Ryk, Liping Wang, Dennis R. Burton, Ernesto Freire, Richard Wyatt, Joseph Sodroski, Wayne A. Hendrickson and James Arthos

doi:10.1038/nature01188

First paragraph | Full Text | PDF (273K) | Supplementary information

See also: News and Views by Jardetzky

Asymmetric inheritance of centrosomally localized mRNAs during embryonic cleavages p682

J. David Lambert and Lisa M. Nagy

doi:10.1038/nature01241

First paragraph | Full Text | PDF (342K)

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans p686

Daniel D. Shaye and Iva Greenwald

doi:10.1038/nature01234

First paragraph | Full Text | PDF (408K) | Supplementary information

Signal-dependent regulation of splicing via phosphorylation of Sam68 p691

Nathalie Matter, Peter Herrlich and Harald König

doi:10.1038/nature01153

First paragraph | Full Text | PDF (365K)

Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand p696

Ivan Bosanac, Jean-René Alattia, Tapas K. Mal, Jenny Chan, Susanna Talarico, Frances K. Tong, Kit I. Tong, Fumio Yoshikawa, Teiichi Furuichi, Miwako Iwai, Takayuki Michikawa, Katsuhiko Mikoshiba and Mitsuhiko Ikura

doi:10.1038/nature01268

First paragraph | Full Text | PDF (1,388K) | Supplementary information

erratum: The strength of Mg_0.9Fe_0.1Si0₃ perovskite at high pressure and temperature p700

Jiuhua Chen, Donald J. Weldner and Michael T. Vaughan

doi:10.1038/nature01293

Full Text | PDF (63K)

New on the Market

Cellular solutions p701

The latest cell biology products, including a free CD-ROM.

doi:10.1038/420701a

Full Text | PDF (119K)

Alliance for Cellular Signaling Supplement

Overview of the Alliance for Cellular Signaling p703

and Participating investigators and scientists of the Alliance for Cellular Signaling

doi:10.1038/nature01304

Abstract | Full Text | PDF (75K)

Unravelling the signal-transduction network in B lymphocytes p708

Gilberto R. Sambrano, Grischa Chandy, Sangdun Choi, Dianne Decamp, Robert Hsueh, Keng-Mean Lin, Dennis Mock, Nancy O'Rourke, Tamara Roach, Hongjun Shu, Bob Sinkovits, Mary Verghese and Henry Bourne

doi:10.1038/nature01305

Abstract | Full Text | PDF (71K)

Navigating the signalling network in mouse cardiac myocytes p712

Gilberto R. Sambrano, Iain Fraser, Heping Han, Yan Ni, Tim O'Connell, Zhen Yan and James T. Stull

doi:10.1038/nature01306

Abstract | Full Text | PDF (166K)

The Molecule Pages database p716

Joshua Li, Yuhong Ning, Warren Hedley, Brian Saunders, Yongsheng Chen, Nicole Tindill, Timo Hannay and Shankar Subramaniam

doi:10.1038/nature01307

Abstract | Full Text | PDF (168K)