Naturejobs

Part-time growth p3

Paul Smaglik

doi:10.1038/nj6912-03a

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Opinion

The trials of gene therapy p107

The news that a child in a gene-therapy trial has developed cancer has cast a cloud over the technique. But this has more to do with the field's chequered history than the particular circumstances of this tragic case.

doi:10.1038/420107a

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Frameworks can be too rigid p107

There are lessons to be learned from scientists' responses to the European Commission's latest research programme.

doi:10.1038/420107b

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News

Microbe hunt raises doubts over local benefits of bioprospecting p109

David Cyranoski

doi:10.1038/420109a

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Ground-breaking web test gears up p109

Geoff Brumfiel

doi:10.1038/420109b

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Call for more data forms basis of Bush climate strategy p110

Tony Reichhardt

doi:10.1038/420110a

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Outcry greets US plan to test smallpox vaccine on children p110

Erika Check

doi:10.1038/420110b

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Tribe blasts 'exploitation' of blood samples p111

Rex Dalton

doi:10.1038/420111a

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Space station set for sky-high profile p111

David Adam

doi:10.1038/420111b

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Conduct code mooted for bioweapons treaty p112

Natasha McDowell

doi:10.1038/420112a

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Academy slams Internet arts and sciences lookalike p112

David Adam

doi:10.1038/420112b

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Republican win sparks fears for science funds p113

Geoff Brumfiel

doi:10.1038/420113a

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Venus Express cleared for take-off p113

Alison Abbott and Quirin Schiermeier

doi:10.1038/420113b

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news in brief p114

doi:10.1038/420114a

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news feature

Gene therapy: A tragic setback p116

With one French gene-therapy patient having developed a form of cancer, a frantic detective effort is under way to determine what went wrong — and to assess the risks faced by others. Erika Check reports.

Erika Check

doi:10.1038/420116a

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Negative refraction: A lens less ordinary p119

In the 1960s, a Russian physicist considered the properties of a material that didn't yet exist. Now researchers appear to have fulfilled his predictions — but is everything as it seems? Liesbeth Venema investigates.

Liesbeth Venema

doi:10.1038/420119a

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Correspondence

The next challenge is to map the human mind p121

An ambitious project aims to chart the territory of ideas: vast but, conceivably, not infinite.

Darryl R. J. Macer

doi:10.1038/420121a

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Moving beyond 'industry vs ecologists' stereotype p121

Allison A. Snow

doi:10.1038/420121b

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Liberal world of science p121

Geraint Day

doi:10.1038/420121c

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Book Reviews

Living with capitalism p123

Similar processes affect cells and businesses. But what price sustainability?

Crispin Tickell reviews The Hidden Connections: Integrating the Biological, Cognitive, and Social Dimensions of Life into a Science of Sustainability/The Hidden Connections: A Science for Sustainable Living by Fritjof Capra

doi:10.1038/420123a

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A political view of ecology p124

Michael Ruse and Nils Chr. Stenseth review Imperial Ecology: Environmental Order in the British Empire, 1895–1945 by Peder Anker

doi:10.1038/420124a

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Bringing speciation to the surface p125

Ernst Mayr reviews Adaptive Radiation of Blind Subterranean Mole Rats by E. Nevo, E. Ivanitskaya and A. Beiles

doi:10.1038/420125a

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Trying to figure it out p125

Jeremy Gray reviews The Millennium Problems: The Seven Greatest Unsolved Mathematical Puzzles of Our Time by Keith Devlin

doi:10.1038/420125b

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Seminal Nature in Japanese p125

doi:10.1038/420125c

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Science in culture p126

Alison Abbott reviews

doi:10.1038/420126b

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concepts

Epigenetic reprogramming: Back to the beginning p127

Wolf Reik and Wendy Dean

doi:10.1038/420127a

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News and Views

Systems biology: Metabolic balance sheets p129

Application of book-keeping principles to metabolic networks provides a powerful technique for understanding the properties of microorganisms and predicting the results of genetic modification.

Athel Cornish-Bowden and María Luz Cárdenas

doi:10.1038/420129a

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Earth science: Is it all in the crust? p130

New observations suggest that earthquakes on land are only 'skin-deep', confined to the Earth's outermost layer of crust. This has prompted a rethink of what gives the tectonic plates their strength.

Simon Lamb

doi:10.1038/420130a

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Applied physics: Terahertz power p131

Although radiation at terahertz frequencies has many uses, most sources cannot generate terahertz beams with great power. Magnetic manipulation of energetic electrons inside a particle accelerator offers a solution.

Mark Sherwin

doi:10.1038/420131a

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Neuroscience: Single-neuron mnemonics p133

How can you remember what you've just read or seen or done? The issue of short-term memory has vexed neuroscientists for more than half a century; a new study adds an unexpected piece to the puzzle.

Barry W. Connors

doi:10.1038/420133a

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Solar physics: The Sun under a microscope p134

Fine details of the filamentary structure of sunspots are revealed in new observations. These high-resolution measurements herald the quality of data to be expected from a new generation of solar telescopes.

John H. Thomas

doi:10.1038/420134a

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Medicine: Lipid signals in pain control p135

Cyclooxygenase enzymes produce lipid messenger molecules whose roles in health or disease depend on their context. The discovery of cyclooxygenase-3 should enhance our knowledge of such events.

Nicolas G. Bazan and Rod J. Flower

doi:10.1038/420135a

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Developmental biology: First come, first served p138

It is more than a decade since the discovery that vertebrate Hox genes are arranged and expressed in the same order as the body parts they help to produce. New work looks at how this is achieved in fingers and toes.

Rolf Zeller and Jacqueline Deschamps

doi:10.1038/420138a

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100 and 50 years ago p139

doi:10.1038/420139a

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Obituary: Peter W. Hochachka (1937–2002) p140

Raul K. Suarez and David R. Jones

doi:10.1038/420140a

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Brief Communications

Biomechanics: Halteres used in ancient Olympic long jump p141

These athletes worked out for themselves the optimal size of hand-held weights.

Alberto E. Minetti and Luca P. Ardigó

doi:10.1038/420141a

First paragraph | Full Text | PDF (126K) | Supplementary information

Evolutionary biology (Communication arising): Significance of primate sexual swellings p142

Dietmar Zinner, Susan C. Alberts, Charles L. Nunn and Jeanne Altmann

doi:10.1038/420142a

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Evolutionary biology (Communication arising): Significance of primate sexual swellings p143

Leah G. Domb and Mark Pagel

doi:10.1038/420143a

First paragraph | Full Text | PDF (149K)

Magnetic properties (Communication arising): Parasitic ferromagnetism in a hexaboride? p143

K. Matsubayashi, M. Maki, T. Tsuzuki, T. Nishioka and N. K. Sato

doi:10.1038/420143b

First paragraph | Full Text | PDF (149K)

Magnetic properties (Communication arising): Parasitic ferromagnetism in a hexaboride? p144

D. P. Young, Z. Fisk, J. D. Thompson, H. R. Ott, S. B. Oseroff and R. G. Goodrich

doi:10.1038/420144a

First paragraph | Full Text | PDF (135K)

Article

Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs p145

Marie Kmita, Nadine Fraudeau, Yann Hérault and Denis Duboule

doi:10.1038/nature01189

Abstract | Full Text | PDF (389K) | Supplementary information

See also: News and Views by Zeller & Deschamps

Letters to Nature

Dark cores in sunspot penumbral filaments p151

Göran B. Scharmer, Boris V. Gudiksen, Dan Kiselman, Mats G. Löfdahl and Luc H. M. Rouppe van der Voort

doi:10.1038/nature01173

First paragraph | Full Text | PDF (280K) | Supplementary information

See also: News and Views by Thomas

High-power terahertz radiation from relativistic electrons p153

G. L. Carr, Michael C. Martin, Wayne R. McKinney, K. Jordan, George R. Neil and G. P. Williams

doi:10.1038/nature01175

First paragraph | Full Text | PDF (216K)

See also: News and Views by Sherwin

Ferromagnetism of a graphite nodule from the Canyon Diablo meteorite p156

J. M. D. Coey, M. Venkatesan, C. B. Fitzgerald, A. P. Douvalis and I. S. Sanders

doi:10.1038/nature01100

First paragraph | Full Text | PDF (786K)

Tristable nematic liquid-crystal device using micropatterned surface alignment p159

Jong-Hyun Kim, Makoto Yoneya and Hiroshi Yokoyama

doi:10.1038/nature01163

First paragraph | Full Text | PDF (236K)

Variability of El Niño/Southern Oscillation activity at millennial timescales during the Holocene epoch p162

Christopher M. Moy, Geoffrey O. Seltzer, Donald T. Rodbell and David M. Anderson

doi:10.1038/nature01194

First paragraph | Full Text | PDF (187K)

First-principles study of illite–smectite and implications for clay mineral systems p165

Lars Stixrude and Donald R. Peacor

doi:10.1038/nature01155

First paragraph | Full Text | PDF (219K)

Synchronization of animal population dynamics by large-scale climate p168

Eric Post and Mads C. Forchhammer

doi:10.1038/nature01064

First paragraph | Full Text | PDF (268K)

Selective habituation shapes acoustic predator recognition in harbour seals p171

Volker B. Deecke, Peter J. B. Slater and John K. B. Ford

doi:10.1038/nature01030

First paragraph | Full Text | PDF (157K)

Graded persistent activity in entorhinal cortex neurons p173

Alexei V. Egorov, Bassam N. Hamam, Erik Fransén, Michael E. Hasselmo and Angel A. Alonso

doi:10.1038/nature01171

First paragraph | Full Text | PDF (516K) | Supplementary information

See also: News and Views by Connors

The F-box protein Slimb controls the levels of clock proteins Period and Timeless p178

Brigitte Grima, Annie Lamouroux, Elisabeth Chélot, Christian Papin, Bernadette Limbourg-Bouchon and François Rouyer

doi:10.1038/nature01122

First paragraph | Full Text | PDF (328K) | Supplementary information

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response p182

Cecilia Garlanda, Emilio Hirsch, Silvia Bozza, Antonietta Salustri, Marika De Acetis, Rachele Nota, Alessia Maccagno, Federica Riva, Barbara Bottazzi, Giuseppe Peri, Andrea Doni, Luca Vago, Marina Botto, Rita De Santis, Paolo Carminati, Gregorio Siracusa, Fiorella Altruda, Annunciata Vecchi, Luigina Romani and Alberto Mantovani

doi:10.1038/nature01195

First paragraph | Full Text | PDF (406K) | Supplementary information

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth p186

Rafael U. Ibarra, Jeremy S. Edwards and Bernhard O. Palsson

doi:10.1038/nature01149

First paragraph | Full Text | PDF (499K)

Metabolic network structure determines key aspects of functionality and regulation p190

Jörg Stelling, Steffen Klamt, Katja Bettenbrock, Stefan Schuster and Ernst Dieter Gilles

doi:10.1038/nature01166

First paragraph | Full Text | PDF (259K) | Supplementary information

See also: News and Views by Cornish-Bowden & Luz Cárdenas

The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry p193

Haining Zhong, Laurie L. Molday, Robert S. Molday and King-Wai Yau

doi:10.1038/nature01201

First paragraph | Full Text | PDF (648K)

Establishment of transcriptional competence in early and late S phase p198

Jianmin Zhang, Feng Xu, Tamar Hashimshony, Ilana Keshet and Howard Cedar

doi:10.1038/nature01150

First paragraph | Full Text | PDF (335K)

erratum: Reassessing the evidence for the earliest traces of life p202

Mark A. van Zuilen, Aivo Lepland and Gustaf Arrhenius

doi:10.1038/nature01177

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corrigendum: Recovery of 16S ribosomal RNA gene fragments from ancient halite p202

Steven A. Fish, Thomas J. Shepherd, Terry J. McGenity and William D. Grant

doi:10.1038/nature01192

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corrigendum: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA p202

Marcella Calfon, Huiqing Zeng, Fumihiko Urano, Jeffery H. Till, Stevan R. Hubbard, Heather P. Harding, Scott G. Clark and David Ron

doi:10.1038/nature01193

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New on the Market

Stars of the screen p203

The latest releases for high-throughput analysis.

doi:10.1038/420203a

Full Text | PDF (52K)

insight

Computational biology p205

Christopher Surridge

doi:10.1038/nature01253

Full Text | PDF (91K)

Computational systems biology p206

Hiroaki Kitano

doi:10.1038/nature01254

Abstract | Full Text | PDF (122K)

The language of genes p211

David B. Searls

doi:10.1038/nature01255

Abstract | Full Text | PDF (305K)

The structure of the protein universe and genome evolution p218

Eugene V. Koonin, Yuri I. Wolf and Georgy P. Karev

doi:10.1038/nature01256

Abstract | Full Text | PDF (145K)

Engineered gene circuits p224

Jeff Hasty, David McMillen and J. J. Collins

doi:10.1038/nature01257

Abstract | Full Text | PDF (255K)

Control, exploitation and tolerance of intracellular noise p231

Christopher V. Rao, Denise M. Wolf and Adam P. Arkin

doi:10.1038/nature01258

Abstract | Full Text | PDF (540K)

Computational approaches to cellular rhythms p238

Albert Goldbeter

doi:10.1038/nature01259

Abstract | Full Text | PDF (256K)

The community of the self p246

Timothy G. Buchman

doi:10.1038/nature01260

Abstract | Full Text | PDF (221K)