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Nature 418, 252-258 (11 July 2002) | doi:10.1038/418252a
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Director, UQ Centre for Clinical Research
- University of Queensland, Brisbane, Australia
- Brisbane, Queensland, Australia
Beamline Scientist PROXIMA 2
- Synchrotron Soleil
- Gif Sur Yvette 91190 France
review article Emerging clinical applications of RNA
Bruce A. Sullenger & Eli Gilboa
Abstract
RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our genetic information. It is not surprising then that researchers have sought to exploit the inherent properties of RNAs so as to interfere with or repair dysfunctional nucleic acids or proteins and to stimulate the production of therapeutic gene products in a variety of pathological situations. The first generation of the resulting RNA therapeutics are now being evaluated in clinical trials, raising significant interest in this emerging area of medical research.
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