Table of contents


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Naturejobs

Prospects

Moving benchmarks p3

Paul Smaglik

doi:10.1038/nj6868-03a


postdocs

Postdocs & students: Private foundations push for higher postdoc salaries p5

Karen Kreeger

doi:10.1038/nj6868-05a


Top

Opinion

Errors in citation statistics p101

A curious absence from a list of 'hot papers' has led Nature to uncover some inaccuracies in the citation statistics compiled by the ISI. This adds to worries about relying heavily on these figures when rating scientific performance.

doi:10.1038/415101a


Lynch mob turns on lynx researchers p101

Biologists who tried to test the performance of a lab conducting genetic analysis have been unfairly pilloried.

doi:10.1038/415101b


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News

Xenotransplant experts express caution over knockout piglets p103

Declan Butler

doi:10.1038/415103a


Clone pioneer calls for health tests p103

David Adam

doi:10.1038/415103b


Argentina's crisis heralds time of torment for scientists p104

Carol Marzuola

doi:10.1038/415104a


Legal move could open door to physics lab p105

Irwin Goodwin

doi:10.1038/415105a


Bushfires leave ecologists hot under the collar p105

Peter Pockley

doi:10.1038/415105b


Whale deaths caused by US Navy's sonar p106

Mark Schrope

doi:10.1038/415106a


NIH faces action over HIV cat study p106

Erika Check

doi:10.1038/415106b


Fur flies over lynx survey's suspect samples p107

Rex Dalton

doi:10.1038/415107a


Charges over computing project may set precedent p107

Erika Check

doi:10.1038/415107b


news in brief p108

doi:10.1038/415108a


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news feature

Shorter, brighter, better p110

A laser technology with military roots looks set to make a big impact on biology. By creating short pulses of intense radiation, free-electron lasers will advance our understanding of biological molecules. Navroz Patel reports.

Navroz Patel

doi:10.1038/415110a


Betting on tomorrow's chips p112

At the proteomics frontier, dozens of companies are trying to develop the protein equivalent of DNA microarrays. But designing these chips poses much tougher technical challenges, says Alison Abbott.

Alison Abbott

doi:10.1038/415112a


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Correspondence

Theoretical models of sheep BSE reveal possibilities p115

But we must remember that these theories are based on speculation, not on fact.

John R. Krebs, Robert M. May and Michael P. H. Stumpf

doi:10.1038/415115a


Dropped genetics paper lacked scientific merit p115

Neil Risch, Alberto Piazza and L. Luca Cavalli-Sforza

doi:10.1038/415115b


Top

Book Reviews

Why natural may not equal healthy p117

Many believe that the natural toxins in their food are safer than synthetic ones.

John Krebs reviews Naturally Dangerous: Surprising Facts about Food, Health, and the Environment by James P. Collman

doi:10.1038/415117a


Life as a freeloader p117

J. C. Koella and C. D. M. Müller-Graf review Les associations du vivant: L'art d'être parasite by Claude Combes

doi:10.1038/415117b


A Universal view p119

John E. Chambers reviews Higher Than Everest: An Adventurer's Guide to the Solar System by Paul Hodge and Solar System Evolution: A New Perspective. 2nd edition by Stuart Ross Taylor

doi:10.1038/415119a


A jaunt through the Solar System p119

doi:10.1038/415119b


Talking techno p120

Geoffrey Nunberg reviews Language and the Internet by David Crystal

doi:10.1038/415120a


Gone — but not forgotten p120

doi:10.1038/415120b


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concepts

Seeking universals p121

Melvin Konner

doi:10.1038/415121a


Top

News and Views

Proteomics: Protein complexes take the bait p123

Many cellular functions are carried out by proteins that are bound together in complexes. In two new large-scale studies, labelled proteins are used as 'bait' to capture and identify those complexes.

Anuj Kumar and Michael Snyder

doi:10.1038/415123a


Oceanography: Bubbling under p124

The study of hydrothermal vents is a young and fertile discipline. The latest findings, and the enticing prospects offered by new technology, came in for discussion at two meetings held late last year.

Chris German

doi:10.1038/415124a


Behavioural science: Homo reciprocans p125

Humans are often generous, but cooperation unravels when others take advantage of them. Many people punish such 'free riders', even if they do not benefit personally, and this 'altruistic punishment' sustains cooperation.

Samuel Bowles and Herbert Gintis

doi:10.1038/415125a


100 and 50 years ago p127

doi:10.1038/415127a


Astronomy: X-rays reveal the Galaxy's centre p128

For twenty years astronomers have wondered what is responsible for the X-ray emission from the centre of our Galaxy. New data from the sharpest X-ray eye around — the Chandra observatory — reveal all.

Andreas Eckart

doi:10.1038/415128a


Molecular motors: Stretching the lever-arm theory p129

Motor proteins are essential to life: without them, all cellular transport would grind to a halt. New results on the size of steps taken by one family of motors, the myosins, will fuel the debate about how they move.

Michael A. Geeves

doi:10.1038/415129a


Global change: Getting cool with nitrogen p131

Variations in the marine nitrogen cycle are implicated in driving glacial–interglacial climate change and producing warm spells during glacial periods. But phosphorus may also need to be taken into account.

Allan H. Devol

doi:10.1038/415131a


Daedalus: Hold on to your heat p132

David Jones

doi:10.1038/415132a


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Brief Communications

Visual systems: Predator and prey views of spider camouflage p133

Both hunter and hunted fail to notice crab-spiders blending with coloured petals.

Marc Théry and Jérôme Casas

doi:10.1038/415133a


Brain evolution (Communication arising): Analysis of mammalian brain architecture p133

Fahad Sultan

doi:10.1038/415133b


Brain evolution (Communications arising): How did brains evolve? p134

Robert A. Barton

doi:10.1038/415134a


Brain evolution (Communications arising): How did brains evolve? p135

Samuel S.-H. Wang, Partha P. Mitra and Damon A. Clark

doi:10.1038/415135a


Top

Articles

Altruistic punishment in humans p137

Ernst Fehr and Simon Gächter

doi:10.1038/415137a

See also: News and Views by Bowles & Gintis


Functional organization of the yeast proteome by systematic analysis of protein complexes p141

Anne-Claude Gavin, Markus Bösche, Roland Krause, Paola Grandi, Martina Marzioch, Andreas Bauer, Jörg Schultz, Jens M. Rick, Anne-Marie Michon, Cristina-Maria Cruciat, Marita Remor, Christian Höfert, Malgorzata Schelder, Miro Brajenovic, Heinz Ruffner, Alejandro Merino, Karin Klein, Manuela Hudak, David Dickson, Tatjana Rudi, Volker Gnau, Angela Bauch, Sonja Bastuck, Bettina Huhse, Christina Leutwein, Marie-Anne Heurtier, Richard R. Copley, Angela Edelmann, Erich Querfurth, Vladimir Rybin, Gerard Drewes, Manfred Raida, Tewis Bouwmeester, Peer Bork, Bertrand Seraphin, Bernhard Kuster, Gitte Neubauer and Giulio Superti-Furga

doi:10.1038/415141a

See also: News and Views by Kumar & Snyder


Top

Letters to Nature

A faint discrete source origin for the highly ionized iron emission from the Galactic Centre region p148

Q. D. Wang, E. V. Gotthelf and C. C. Lang

doi:10.1038/415148a

See also: News and Views by Eckart


Transition-metal-based magnetic refrigerants for room-temperature applications p150

O. Tegus, E. Brück, K. H. J. Buschow and F. R. de Boer

doi:10.1038/415150a


Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna p152

Kimberly Hamad-Schifferli, John J. Schwartz, Aaron T. Santos, Shuguang Zhang and Joseph M. Jacobson

doi:10.1038/415152a


Reduced nitrogen fixation in the glacial ocean inferred from changes in marine nitrogen and phosphorus inventories p156

Raja S. Ganeshram, Thomas F. Pedersen, Stephen Calvert and Roger François

doi:10.1038/415156a

See also: News and Views by Devol


The effect of millennial-scale changes in Arabian Sea denitrification on atmospheric CO2 p159

Mark A. Altabet, Matthew J. Higginson and David W. Murray

doi:10.1038/415159a

See also: News and Views by Devol


Parasitic Cape honeybee workers, Apis mellifera capensis, evade policing p163

Stephen J. Martin, Madeleine Beekman, Theresa C. Wossler and Francis L. W. Ratnieks

doi:10.1038/415163a


Dynamic coding of behaviourally relevant stimuli in parietal cortex p165

Louis J. Toth and John A. Assad

doi:10.1038/415165a


Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo p168

Hiromi Yanagisawa, Elaine C. Davis, Barry C. Starcher, Takashi Ouchi, Masashi Yanagisawa, James A. Richardson and Eric N. Olson

doi:10.1038/415168a


Fibulin-5/DANCE is essential for elastogenesis in vivo p171

Tomoyuki Nakamura, Pilar Ruiz Lozano, Yasuhiro Ikeda, Yoshitaka Iwanaga, Aleksander Hinek, Susumu Minamisawa, Ching-Feng Cheng, Kazuhiro Kobuke, Nancy Dalton, Yoshikazu Takada, Kei Tashiro, John Ross Jr, Tasuku Honjo and Kenneth R. Chien

doi:10.1038/415171a


Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface p175

George L. Dale, Paul Friese, Peter Batar, Stephen F. Hamilton, Guy L. Reed, Kenneth W. Jackson, Kenneth J. Clemetson and Lorenzo Alberio

doi:10.1038/415175a


Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry p180

Yuen Ho, Albrecht Gruhler, Adrian Heilbut, Gary D. Bader, Lynda Moore, Sally-Lin Adams, Anna Millar, Paul Taylor, Keiryn Bennett, Kelly Boutilier, Lingyun Yang, Cheryl Wolting, Ian Donaldson, Søren Schandorff, Juanita Shewnarane, Mai Vo, Joanne Taggart, Marilyn Goudreault, Brenda Muskat, Cris Alfarano, Danielle Dewar, Zhen Lin, Katerina Michalickova, Andrew R. Willems, Holly Sassi, Peter A. Nielsen, Karina J. Rasmussen, Jens R. Andersen, Lene E. Johansen, Lykke H. Hansen, Hans Jespersen, Alexandre Podtelejnikov, Eva Nielsen, Janne Crawford, Vibeke Poulsen, Birgitte D. Sørensen, Jesper Matthiesen, Ronald C. Hendrickson, Frank Gleeson, Tony Pawson, Michael F. Moran, Daniel Durocher, Matthias Mann, Christopher W. V. Hogue, Daniel Figeys and Mike Tyers

doi:10.1038/415180a

See also: News and Views by Kumar & Snyder


Alternative nucleotide incision repair pathway for oxidative DNA damage p183

Alexander A. Ischenko and Murat K. Saparbaev

doi:10.1038/415183a


Co-regulator recruitment and the mechanism of retinoic acid receptor synergy p187

Pierre Germain, Jaya Iyer, Christina Zechel and Hinrich Gronemeyer

doi:10.1038/415187a


The motor domain determines the large step of myosin-V p192

Hiroto Tanaka, Kazuaki Homma, Atsuko Hikikoshi Iwane, Eisaku Katayama, Reiko Ikebe, Junya Saito, Toshio Yanagida and Mitsuo Ikebe

doi:10.1038/415192a

See also: News and Views by Geeves


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New on the Market

January sales p196

A miscellany from recent product launches.

doi:10.1038/415196a


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insight

foreword

the heart p197

Karen Birmingham

doi:10.1038/415197a


review article

Cardiac excitation–contraction coupling p198

Donald M. Bers

doi:10.1038/415198a


Seven-transmembrane-spanning receptors and heart function p206

Howard A. Rockman, Walter J. Koch and Robert J. Lefkowitz

doi:10.1038/415206a


Cardiac channelopathies p213

Eduardo Marbán

doi:10.1038/415213a


New ideas about atrial fibrillation 50 years on p219

Stanley Nattel

doi:10.1038/415219a


The failing heart p227

J. A. Towbin and N. E. Bowles

doi:10.1038/415227a


Myocardial gene therapy p234

Jeffrey M. Isner

doi:10.1038/415234a


progress

Myocyte renewal and ventricular remodelling p240

Piero Anversa and Bernardo Nadal-Ginard

doi:10.1038/415240a


corporate support

The Heart and Drug Therapy p244

Peter Thoren, Ingemar Jacobson, Håkan Wennbo and Mikael Dohlsten

doi:10.1038/415244a


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