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HIV chemotherapy

Nature volume 410, pages 995–1001 (2001)Cite this article

Abstract

The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenesis and the viral and cellular dynamics of HIV infection. But challenges remain. Treatment does not suppress HIV replication in all patients, and the emergence of drug-resistant virus hinders subsequent treatment. Chronic therapy can also result in toxicity. These challenges prompt the search for new drugs and new therapeutic strategies to control chronic viral replication.

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Figure 1: Three-year treatment with indinavir, zidovudine and lamivudine.
Figure 2: Estimated incidence of AIDS and deaths of adults/adolescents with AIDS in the United States during the period 1985–1999.
Figure 3: Mechanism of action of nucleoside and non-nucleoside reverse-transcriptase inhibitors.
Figure 4: Mechanism of action of protease inhibitors.

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Acknowledgements

A limited review of such an extensive field can achieve neither completeness nor balance. I apologize to my many colleagues whose contributions have not been explicitly acknowledged. D.R. is supported by grants from the UCSD Center for AIDS Research, the National Institutes of Health, and the Research Center for AIDS and HIV Infection of the Veterans Affairs San Diego Healthcare System.

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  1. Departments of Pathology and Medicine 0679, Veterans Affairs San Diego Healthcare System and University of California San Diego, 9500 Gilman Drive, La Jolla, 92093-0679, California, USA

    Douglas D. Richman

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Richman, D. HIV chemotherapy. Nature 410, 995–1001 (2001). https://doi.org/10.1038/35073673

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