Table of contents
Volume 410 Number 6824 pp1-130
Opinion
China's hopes and hypes p1
The scientific potential of China is great. Recent initiatives reflect the government's justified ambition for research. They also highlight unjustified secrecy and misguided policy agendas.
doi:10.1038/35065261
News
Bush declines to support drug companies' line on AIDS profits p3
David Dickson
doi:10.1038/35065220
Growers cotton on to GM bollworm p3
Rex Dalton
doi:10.1038/35065223
Farmers act to avert foot-and-mouth crisis p4
Jim Giles
doi:10.1038/35065263
Europe frames fresh funding initiative for research p4
Quirin Schiermeier
GlaxoSmithKline pushes its labs towards 'biotech' future p5
David Adam
doi:10.1038/35065225
Hepatitis pioneer takes the reins for French medicine p5
Declan Butler
doi:10.1038/35065228
Benefits of low-tar smokes just a pipe dream p6
Corie Lok
doi:10.1038/35065231
Museum suffers spiritual cramps over Mendel's work p6
David Adam
doi:10.1038/35065233
Goal-directed revamp for Japanese research p7
David Cyranoski
doi:10.1038/35065236
Israel seeks sweet smell of success p7
Haim Watzman
doi:10.1038/35065239
news feature
A great leap forward p10
After helping to sequence the human genome, Chinese scientists are debating how best to continue the push towards becoming a world power in biology. David Cyranoski reports.
David Cyranoski
doi:10.1038/35065246
Politics, ethics and collaborations p11
doi:10.1038/35065252
Breaking the mould p13
In choosing an outspoken former government science adviser as its president, the Royal Society has departed from tradition. Peter Aldhous spoke to Robert May about his plans for Britain's national scientific academy.
Peter Aldhous
doi:10.1038/35065254
Correspondence
All sectors of society must work together to save biodiversity p14
Jatna Supriatna
doi:10.1038/35065257
High rate of inbreeding in Spanish universities p14
Arcadio Navarro and Ana Rivero
doi:10.1038/35065259
Book Reviews
Highlighting the grey matter p15
An attempt to answer the perennial questions of neuroscience.
Steven P. R. Rose reviews What Makes You Tick? The Brain in Plain English by Thomas B. Czerner
doi:10.1038/35065145
The real benefits of copycats p16
Stephen Pruett-Jones reviews The Imitation Factor: Evolution Beyond the Gene by Lee Alan Dugatkin
doi:10.1038/35065148
Evolutionary celebrities p17
Axel Meyer reviews The Cichlid Fishes: Nature's Grand Experiment in Evolution by George W. Barlow
doi:10.1038/35065151
Science in culture p18
Richard Taylor reviews
words
Character-building p19
How do writing systems such as China's deal with the twenty-first century?
Alan L. Mackay
doi:10.1038/35065171
News and Views
Genie in a bottle p23
An overlooked compound has a surprise in store for physicists. It becomes superconducting at a much higher temperature than any other stable metallic compound.
Robert J. Cava
doi:10.1038/35065177
Cancer: An attractive force in metastasis p24
In breast-cancer patients, secondary tumours often form in the lungs and bone marrow, for example, but rarely in the kidneys. The explanation for this bias involves soluble attractant molecules called chemokines.
Lance A. Liotta
doi:10.1038/35065180
Planetary science: Icing Ganymede p25
Much of Jupiter's moon Ganymede is covered in comparatively young ice. Images from spacecraft are providing clues about whether this resurfacing occurred primarily through tectonic or volcanic events.
Louise M. Prockter
doi:10.1038/35065183
100 and 50 years ago p27
doi:10.1038/35065186
Particle physics: Precision precession p28
The most accurate measurement yet of the way an elementary particle wobbles — precesses — in a magnetic field is getting physicists excited. If it is right, we may be on the threshold of a new era of particle discoveries.
Frank Wilczek
doi:10.1038/35065188
Molecular biology: A big development for a small RNA p29
The RNA-processing enzyme MRP contains an RNA component that is essential for its activity. Unexpectedly, it seems that mutations in the gene encoding this RNA cause a multifaceted human disease.
David A. Clayton
doi:10.1038/35065191
Animal husbandry: Assessing the welfare state p31
Michael Mendl
doi:10.1038/35065194
Materials science: All chopped up p31
Physicists are always looking for new ways to increase the capacity of hard disks and data tapes. One method involves dicing magnetic media into little bits.
Josette Chen
doi:10.1038/35065196
Condensed matter: Memories of paste p32
Pastes are not the simple materials they appear to be. It seems they have a 'memory': after a force has been applied, they recover and move back in the opposite direction.
David A. Weitz
doi:10.1038/35065199
Apoptosis: Baiting death inhibitors p33
Enzymes called caspases that start the process of programmed cell death can be dangerous if activated at the wrong time. A feat of self-restraint keeps one such caspase under control.
Donald W. Nicholson
doi:10.1038/35065201
Brief Communications
Frustrations of fur-farmed mink p35
Mink may thrive in captivity but they miss having water to romp about in.
Georgia J. Mason, Jonathan Cooper and Catherine Clarebrough
doi:10.1038/35065157
See also: News and Views by Mendl
Structural colour: Now you see it — now you don't p36
P. Vukusic, J. R. Sambles, C. R. Lawrence and R. J. Wootton
doi:10.1038/35065161
First paragraph | Full Text | PDF (190K)
erratum: A viable herd of genetically uniform cattle p36
P.M. Visscher
Progress
Mammalian MAP kinase signalling cascades p37
Lufen Chang and Michael Karin
doi:10.1038/35065000
Abstract | Full Text | PDF (181K)
Articles
Synaptotagmin I functions as a calcium regulator of release probability p41
Rafael Fernández-Chacón, Andreas Königstorfer, Stefan H. Gerber, Jesús García, Maria F. Matos, Charles F. Stevens, Nils Brose, Josep Rizo, Christian Rosenmund and Thomas C. Südhof
doi:10.1038/35065004
Abstract | Full Text | PDF (440K) | Supplementary information
Involvement of chemokine receptors in breast cancer metastasis p50
Anja Müller, Bernhard Homey, Hortensia Soto, Nianfeng Ge, Daniel Catron, Matthew E. Buchanan, Terri McClanahan, Erin Murphy, Wei Yuan, Stephan N. Wagner, Jose Luis Barrera, Alejandro Mohar, Emma Verástegui and Albert Zlotnik
doi:10.1038/35065016
Abstract | Full Text | PDF (715K) | Supplementary information
See also: News and Views by Liotta
Letters to Nature
Flooding of Ganymede's bright terrains by low-viscosity water-ice lavas p57
Paul M. Schenk, William B. McKinnon, David Gwynn and Jeffrey M. Moore
doi:10.1038/35065027
First paragraph | Full Text | PDF (517K)
See also: News and Views by Prockter
Coherent manipulation of semiconductor quantum bits with terahertz radiation p60
B. E. Cole, J. B. Williams, B. T. King, M. S. Sherwin and C. R. Stanley
doi:10.1038/35065032
First paragraph | Full Text | PDF (460K)
Superconductivity at 39 K in magnesium diboride p63
Jun Nagamatsu, Norimasa Nakagawa, Takahiro Muranaka, Yuji Zenitani and Jun Akimitsu
doi:10.1038/35065039
First paragraph | Full Text | PDF (151K)
See also: News and Views by Cava
Non-thermal melting in semiconductors measured at femtosecond resolution p65
A. Rousse, C. Rischel, S. Fourmaux, I. Uschmann, S. Sebban, G. Grillon, Ph. Balcou, E. Förster, J.P. Geindre, P. Audebert, J.C. Gauthier and D. Hulin
doi:10.1038/35065045
First paragraph | Full Text | PDF (170K) | Supplementary information
Propagating solitary waves along a rapidly moving crack front p68
Eran Sharon, Gil Cohen and Jay Fineberg
doi:10.1038/35065051
First paragraph | Full Text | PDF (324K)
Orbit-related long-term climate cycles revealed in a 12-Myr continental record from Lake Baikal p71
Kenji Kashiwaya, Shinya Ochiai, Hideo Sakai and Takayoshi Kawai
doi:10.1038/35065057
First paragraph | Full Text | PDF (275K) | Supplementary information
Earthquake slip on oceanic transform faults p74
Rachel E. Abercrombie and Göran Ekström
doi:10.1038/35065064
First paragraph | Full Text | PDF (386K)
Isotopic evidence for microbial sulphate reduction in the early Archaean era p77
Yanan Shen, Roger Buick and Donald E. Canfield
doi:10.1038/35065071
First paragraph | Full Text | PDF (262K) | Supplementary information
A primitive sarcopterygian fish with an eyestalk p81
Min Zhu, Xiaobo Yu and Per E. Ahlberg
doi:10.1038/35065078
First paragraph | Full Text | PDF (287K) | Supplementary information
Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 p84
Chien-liang Glenn Lin, Irina Orlov, Alicia M. Ruggiero, Margaret Dykes-Hoberg, Andy Lee, Mandy Jackson and Jeffrey D. Rothstein
doi:10.1038/35065084
First paragraph | Full Text | PDF (309K) | Supplementary information
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins p89
Mandy Jackson, Wei Song, Mu-Ya Liu, Lin Jin, Margaret Dykes-Hoberg, Chien-liang G. Lin, William J. Bowers, Howard J. Federoff, Paul C. Sternweis and Jeffrey D. Rothstein
doi:10.1038/35065091
First paragraph | Full Text | PDF (292K) | Supplementary information
Aberrant CFTR-dependent HCO-3 transport in mutations associated with cystic fibrosis p94
Joo Young Choi, Daniella Muallem, Kirill Kiselyov, Min Goo Lee, Philip J. Thomas and Shmuel Muallem
doi:10.1038/35065099
First paragraph | Full Text | PDF (321K) | Supplementary information
Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice p97
Elizabeth A. Lindsay, Francesca Vitelli, Hong Su, Masae Morishima, Tuong Huynh, Tiziano Pramparo, Vesna Jurecic, George Ogunrinu, Helen F. Sutherland, Peter J. Scambler, Allan Bradley and Antonio Baldini
doi:10.1038/35065105
First paragraph | Full Text | PDF (374K)
Visualizing the generation of memory CD4 T cells in the whole body p101
R. Lee Reinhardt, Alexander Khoruts, Rebecca Merica, Traci Zell and Marc K. Jenkins
doi:10.1038/35065111
First paragraph | Full Text | PDF (519K)
Skewed maturation of memory HIV-specific CD8 T lymphocytes p106
Patrick Champagne, Graham S. Ogg, Abigail S. King, Christian Knabenhans, Kim Ellefsen, Massimo Nobile, Victor Appay, G. Paolo Rizzardi, Sylvain Fleury, Martin Lipp, Reinhold Förster, Sarah Rowland-Jones, Rafick-P. Sékaly, Andrew J. McMichael and Giuseppe Pantaleo
doi:10.1038/35065118
First paragraph | Full Text | PDF (320K)
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis p112
Srinivasa M. Srinivasula, Ramesh Hegde, Ayman Saleh, Pinaki Datta, Eric Shiozaki, Jijie Chai, Ryung-Ah Lee, Paul D. Robbins, Teresa Fernandes-Alnemri, Yigong Shi and Emad S. Alnemri
doi:10.1038/35065125
First paragraph | Full Text | PDF (340K)
See also: News and Views by Nicholson
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins p116
Monika Lachner, Dónal O'Carroll, Stephen Rea, Karl Mechtler and Thomas Jenuwein
doi:10.1038/35065132
First paragraph | Full Text | PDF (228K)
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain p120
Andrew J. Bannister, Philip Zegerman, Janet F. Partridge, Eric A. Miska, Jean O. Thomas, Robin C. Allshire and Tony Kouzarides
doi:10.1038/35065138
First paragraph | Full Text | PDF (442K)
New on the Market
Scanning the spectrum p125
Programs, gadgets and instrumentation for spectroscopy and fluorimetry.
doi:10.1038/35065166
Careers and Recruitment
Better microscopes will be instrumental in nanotechnology development p127
Customizing and combining existing tools may help advance the fledgling field of nanoscience, says Steve Bunk.
Steve Bunk
doi:10.1038/35065204
Sandia scientists develop instruments at the crossroads p128
Steve Bunk
doi:10.1038/35065208
Mass-spectrometry experience is in demand p129
Alok Jha and Paul Smaglik
doi:10.1038/35065211
