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CD1-restricted T-cell responses and microbial infection

Nature volume 406, pages 788–792 (2000)Cite this article

Abstract

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC–peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

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Figure 1
Figure 2: The Mycobacterium tuberculosis cell envelope.
Figure 3: A comparison of the hydrophobicity of CD1d and H2-Kb antigen-binding grooves.
Figure 4: Cellular location of CD1a, CD1b, CD1c, CD1d and corresponding CD1-restricted T-cell subsets and lipid antigens.

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Acknowledgements

We thank S. Balk, M. Bonneville, M. Ferguson, J.-J. Fournie, S. Joyce, S. Kaufmann, Y. Koezuka, H.R. MacDonald, I. Orme, S. Porcelli, L. Schofield, L. Teyton, C.-R. Wang and numerous other colleagues for helpful discussions and for sharing unpublished results; P. Brennan for permission to reproduce his model of the mycobacterial cell wall; members of our laboratory for stimulating discussions; H. Piper for help in the preparation of Fig. 2 ; and B. Jabri and P. Matzinger for critical review of the manuscript. This work was supported by grants from the NIH, American Cancer Society and Juvenile Diabetes Foundation.

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  1. Department of Molecular Biology, Princeton University, Princeton, 08544, New Jersey, USA

    Se-Ho Park & Albert Bendelac

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Park, SH., Bendelac, A. CD1-restricted T-cell responses and microbial infection. Nature 406, 788–792 (2000). https://doi.org/10.1038/35021233

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