Opinion

Science and more for TB p687

Traditional systems for developing drugs are failing spectacularly to deliver the goods in the fight against tuberculosis. Innovative public–private collaborations point the way forward.

doi:10.1038/35001719

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Fossil smuggling unopposed p687

Trading at fossil shows requires law enforcement.

doi:10.1038/35001721

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News

Feathers fly over Chinese fossil bird's legality and authenticity p689

Rex Dalton

doi:10.1038/35001723

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UK scientists under pressure to please p689

Natasha Loder

doi:10.1038/35001725

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The biggest, wildest fossil market in the west p690

Rex Dalton

doi:10.1038/35001727

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Protein structure groups seek to draft common ground rules p691

Paul Smaglik

doi:10.1038/35001729

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Austrian body pleads for normal contacts despite EU freeze p691

Quirin Schiermeier and Patrick Weydt

doi:10.1038/35001731

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South African government rejects AZT advice p692

Michael Cherry

doi:10.1038/35001733

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Consortium aims to kick-start TB research p692

Declan Butler

doi:10.1038/35001735

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Europe's X-ray observatory defies the jinx... p693

Alison Abbott

doi:10.1038/35001737

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...but Astro-E is yet another Japanese failure p693

Robert Triendl

doi:10.1038/35001739

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Russian presidential favourite pledges support for science p694

Carl Levitin

doi:10.1038/35001741

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Republican candidates clash on fetal tissue in research p694

Meredith Wadman

doi:10.1038/35001743

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Funding crisis for Indian biotech centre p694

K. S. Jayaraman

doi:10.1038/35001745

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Oxford professor faces business link inquiry p695

Natasha Loder

doi:10.1038/35001747

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news in brief p696

doi:10.1038/35001749

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Correspondence

Reliance on the citation index undermines the study of biodiversity p698

Antonio G. Valdecasas, Santiago Castroviejo and Leslie F. Marcus

doi:10.1038/35001751

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Proteomics could be key in battle against malaria p698

Virendra K. Bhasin

doi:10.1038/35001753

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X chromosomes forget where they came from p698

Anne McLaren

doi:10.1038/35001755

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Don't let politics put Diamond at risk p698

James H. Naismith

doi:10.1038/35001757

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Commentary

One-stop shop for microarray data p699

Is a universal, public DNA-microarray database a realistic goal?

doi:10.1038/35001676

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Book Reviews

Balancing ambition and restraint p701

India's struggle with its twin desires to have and to renounce the bomb.

Robert W. Cahn reviews India's Nuclear Bomb: The Impact on Global Proliferation By George Perkovich

doi:10.1038/35001645

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Between heavens and cloister p702

Brenda Maddox reviews Galileo's Daughter by Dava Sobel

doi:10.1038/35001648

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A rival for the Burgess Shale p703

Douglas Palmer reviews The Chengjiang Fauna: Exceptionally Well-Preserved Animals from 530 Million Years Ago by Hou Xianguang, Jan Bergström, Wang Haifeng, Feng Xianghong and Chen Ailin

doi:10.1038/35001651

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Problem squares and virtuous circles p703

Jeremy Gray reviews A History of Algorithms: From the Pebble to the Microchip

doi:10.1038/35001654

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Science in culture p704

Martin Kemp reviews Quicker than the eye

doi:10.1038/35001656

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Millennium Essay

Where do babies come from? p705

William Harvey spent a lifetime searching for the earliest moments of life.

R.V. Short

doi:10.1038/35001679

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Futures

Total internal reflection p707

The secret of the accidental immortals can now be made known.

Gwyneth Jones

doi:10.1038/35001682

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News and Views

Linguistics: Taiwan's gift to the world p709

Study of the giant Austronesian language family tells us a great deal about the history of Pacific peoples and boatbuilding, as well as about Aboriginal Australia.

Jared M. Diamond

doi:10.1038/35001685

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Display technology: Sidestepping the selection rules p710

I. D. W. Samuel and A. Beeby

doi:10.1038/35001688

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Physiology: Mining the genome for iron p711

Jerry Kaplan and James P. Kushner

doi:10.1038/35001691

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100 and 50 years ago p714

doi:10.1038/35001694

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Climate change: The hole record p714

Jonathan T. Overpeck

doi:10.1038/35001697

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Reproductive biology: A provirus put to work p715

Jonathan P. Stoye and John M Coffin

doi:10.1038/35001700

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Superconductivity: From obscurity to impurity p717

A. V. Balatsky

doi:10.1038/35001703

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Ecology: The complexity of co-dependency p718

Peter J. Morin

doi:10.1038/35001706

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Mathematics: A gathering of groups p719

Ian Stewart

doi:10.1038/35001708

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Developmental biology: Raising the roof p720

Miguel Manzanares and Robb Krumlauf

doi:10.1038/35001711

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Daedalus: Down-gazing Dome p721

David Jones

doi:10.1038/35001714

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Obituary: Dennis Sciama (1926–99) p722

George F.R Ellis

doi:10.1038/35001716

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Brief Communications

Conversion of diploidy to haploidy p723

Individuals susceptible to multigene disorders may now be spotted more easily.

Hai Yan, Nickolas Papadopoulos, Giancarlo Marra, Claudia Perrera, Josef Jiricny, C. Richard Boland, Henry T. Lynch, Robert B. Chadwick, Albert de la Chapelle, Karin Berg, James R. Eshleman, Weishi Yuan, Sanford Markowitz, Steven J. Laken, Christoph Lengauer, Kenneth W. Kinzler and Bert Vogelstein

doi:10.1038/35001659

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Epidemiology: Reactivation of Borrelia infection in birds p724

Åsa Gylfe, Sven Bergström, Jan Lundstróm and Björn Olsen

doi:10.1038/35001663

First paragraph | Full Text | PDF (163K)

Marine ecology: Do mussels take wooden steps to deep-sea vents? p725

Daniel L. Distel, Amy R. Baco, Ellie Chuang, Wendy Morrill, Colleen Cavanaugh and Craig R. Smith

doi:10.1038/35001667

First paragraph | Full Text | PDF (108K)

Articles

Supernova explosions in the Universe p727

Adam Burrows

doi:10.1038/35001501

Abstract | Full Text | PDF (399K)

Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification p734

Kevin J. Lee, Paula Dietrich and Thomas M. Jessell

doi:10.1038/35001507

Abstract | Full Text | PDF (617K)

See also: News and Views by Manzanares & Krumlauf

Letters to Nature

Origin of the Moon's orbital inclination from resonant disk interactions p741

William R. Ward and Robin M. Canup

doi:10.1038/35001516

First paragraph | Full Text | PDF (701K)

Preparing pure photon number states of the radiation field p743

B. T. H. Varcoe, S. Brattke, M. Weidinger and H. Walther

doi:10.1038/35001526

First paragraph | Full Text | PDF (335K)

Imaging the effects of individual zinc impurity atoms on superconductivity in Bi₂Sr₂CaCu₂O₈₊ p746

S. H. Pan, E. W. Hudson, K. M. Lang, H. Eisaki, S. Uchida and J. C. Davis

doi:10.1038/35001534

First paragraph | Full Text | PDF (677K)

See also: News and Views by Balatsky

High-efficiency fluorescent organic light-emitting devices using a phosphorescent sensitizer p750

M. A. Baldo, M. E. Thompson and S. R. Forrest

doi:10.1038/35001541

First paragraph | Full Text | PDF (467K)

See also: News and Views by Samuel & Beeby

Explanation for fracture spacing in layered materials p753

T. Bai, D. D. Pollard and H. Gao

doi:10.1038/35001550

First paragraph | Full Text | PDF (1,049K)

Temperature trends over the past five centuries reconstructed from borehole temperatures p756

Shaopeng Huang, Henry N. Pollack and Po-Yu Shen

doi:10.1038/35001556

First paragraph | Full Text | PDF (1,605K)

See also: News and Views by Overpeck

Effect of stream channel size on the delivery of nitrogen to the Gulf of Mexico p758

Richard B. Alexander, Richard A. Smith and Gregory E. Schwarz

doi:10.1038/35001562

First paragraph | Full Text | PDF (1,216K) | Supplementary information

Producer–decomposer co-dependency influences biodiversity effects p762

Shahid Naeem, Daniel R. Hahn and Gregor Schuurman

doi:10.1038/35001568

First paragraph | Full Text | PDF (158K)

See also: News and Views by Morin

The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS p764

James H. Millonig, Kathleen J. Millen and Mary E. Hatten

doi:10.1038/35001573

First paragraph | Full Text | PDF (413K)

See also: News and Views by Manzanares & Krumlauf

Forebrain peptides modulate sexually polymorphic vocal circuitry p769

James L. Goodson and Andrew H. Bass

doi:10.1038/35001581

First paragraph | Full Text | PDF (271K)

Mapping the conformational wave of acetylcholine receptor channel gating p773

Claudio Grosman, Ming Zhou and Anthony Auerbach

doi:10.1038/35001586

First paragraph | Full Text | PDF (5,970K)

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter p776

Adriana Donovan, Alison Brownlie, Yi Zhou, Jennifer Shepard, Stephen J. Pratt, John Moynihan, Barry H. Paw, Anna Drejer, Bruce Barut, Agustin Zapata, Terence C. Law, Carlo Brugnara, Samuel E. Lux, Geraldine S. Pinkus, Jack L. Pinkus, Paul D. Kingsley, James Palis, Mark D. Fleming, Nancy C. Andrews and Leonard I. Zon

doi:10.1038/35001596

First paragraph | Full Text | PDF (700K)

See also: News and Views by Kaplan & Kushner

Interaction between Wnt and TGF- signalling pathways during formation of Spemann's organizer p781

Michiru Nishita, Minako K. Hashimoto, Souichi Ogata, Micheline N. Laurent, Naoto Ueno, Hiroshi Shibuya and Ken W. Y. Cho

doi:10.1038/35001602

First paragraph | Full Text | PDF (350K) | Supplementary information

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis p785

Sha Mi, Xinhua Lee, Xiang-ping Li, Geertruida M. Veldman, Heather Finnerty, Lisa Racie, Edward LaVallie, Xiang-Yang Tang, Philippe Edouard, Steve Howes, James C. Keith, Jr and John M. McCoy

doi:10.1038/35001608

First paragraph | Full Text | PDF (337K)

See also: News and Views by Stoye & Coffin

nakedcuticle encodes an inducible antagonist of Wnt signalling p789

Wenlin Zeng, Keith A. Wharton, Jr, Judith A. Mack, Kevin Wang, Matthew Gadbaw, Kaye Suyama, Peter S. Klein and Matthew P. Scott

doi:10.1038/35001615

First paragraph | Full Text | PDF (1,296K)

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase p795

Shin-ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein and Leonard Guarente

doi:10.1038/35001622

First paragraph | Full Text | PDF (503K) | Supplementary information

The structures of HslU and the ATP-dependent protease HslU–HslV p800

Matthias Bochtler, Claudia Hartmann, Hyun Kyu Song, Gleb P. Bourenkov, Hans D. Bartunik and Robert Huber

doi:10.1038/35001629

First paragraph | Full Text | PDF (520K)

Structure of the intact transactivation domain of the human papillomavirus E2 protein p805

Alfred A. Antson, Julie E. Burns, Olga V. Moroz, David J. Scott, Cyril M. Sanders, Igor B. Bronstein, G. Guy Dodson, Keith S. Wilson and Norman J. Maitland

doi:10.1038/35001638

First paragraph | Full Text | PDF (496K) | Supplementary information

New on the Market

Biochips on a plate p811

Microarrays in their many guises are the main focus this week.

doi:10.1038/35001670

Full Text | PDF (384K)