Table of contents
Volume 400 Number 6743 pp387-486
Opinion
Dutch researchers' freedoms and responsibilities p387
Following damaging cuts in public spending last year, a new research policy in the Netherlands promises more freedom to researchers to set priorities. But national interests should not be forgotten.
doi:10.1038/22584
Big Science comes of age p387
Talk of the demise of Big Science is premature. But its characteristics have changed significantly.
doi:10.1038/22586
News
Japan declares five-year plan to double genome research funds p389
Asako Saegusa
doi:10.1038/22588
UK ignored BSE vaccine advice, inquiry told p389
Natasha Loder
doi:10.1038/22591
Senate baulks at cost of collider project p390
Colin Macilwain
doi:10.1038/22593
Neurogenetic institute comes to California p390
Rex Dalton
doi:10.1038/22596
NIH budget prospect bright despite political stalemate p391
Meredith Wadman
doi:10.1038/22598
Michigan to use tobacco money to fund life sciences p391
Colin Macilwain
doi:10.1038/22601
Self-navigation put to asteroid fly-by test p392
Tony Reichhardt
doi:10.1038/22603
Scaling the degree of danger from an asteroid p392
Tony Reichhardt
doi:10.1038/22606
Spanish research to receive funding boost p393
Xavier Bosch
doi:10.1038/22609
Monkey dispute halts Indian drug tests p393
K. S. Jayaraman
doi:10.1038/22612
News Analysis
US fusion scientists seeking a fresh start p394
After years of budget cuts and internal division, things are looking up for US fusion research. At a recent meeting,the community began work on a common agenda, and tried to present a united front to funding agencies.
Colin Macilwain
doi:10.1038/22615
NIH weighs in behind improved synchrotrons p395
Meredith Wadman
doi:10.1038/22618
News in Brief p396
doi:10.1038/22621
Correction: ... as government announces creation of genome research consortium p397
doi:10.1038/22624
Correspondence
Precautionary principle stifles discovery p398
Søren Holm and John Harris
doi:10.1038/22626
Funding agencies must use their muscle p398
Benjamin White
doi:10.1038/22628
Substance versus style in scientific papers p398
Marta Pulido
doi:10.1038/22630
Flood warnings p398
Stephen Blackmore
doi:10.1038/22632
Commentary
A manual for planetary management p399
doi:10.1038/22634
Abstract | Full Text | PDF (80K)
News and Views
Rebuilding the road to cancer p401
Jonathan B. Weitzman and Moshe Yaniv
doi:10.1038/22637
Galaxy formation: Mysteries of the Milky Way p402
Gerry Gilmore
doi:10.1038/22640
Microbiology: What's eating the free lunch? p403
Gary J. Olsen
doi:10.1038/22643
100 and 50 years ago p403
doi:10.1038/22645
Condensed-matter science: Magnetic phases to order p405
Neil Mathur
doi:10.1038/22647
Reproductive biology: Distinguished sperm in competition p406
Tim Birkhead
doi:10.1038/22650
Exhibition: Roots of a conservationist p407
Tim Lincoln
doi:10.1038/22653
Earthquakes: Slow ruptures, roaring tsunamis p409
Heidi Houston
doi:10.1038/22656
Apoptosis: All's well that ends dead p410
Timothy S. Zheng and Richard A. Flavell
doi:10.1038/22659
Science policy: The business of research p411
Henk F. Moed and Marc Luwel
doi:10.1038/22662
Bioenergetics: Two phases of proton translocation p412
Denis L. Rousseau
doi:10.1038/22664
Daedalus: No difference at all p413
David Jones
doi:10.1038/22667
Obituary: George Brown (1920-99) p414
Daniel S. Greenberg
doi:10.1038/22669
Millennium Essay
Detonator of the population explosion p415
Vaclav Smil
doi:10.1038/22672
Abstract | Full Text | PDF (126K)
Scientific Correspondence
Chernobyl radioactivity persists in fish p417
Bror Jonsson, TorbjØrn Forseth and Ola Ugedal
doi:10.1038/22675
First paragraph | Full Text | PDF (125K)
Diamond formation from mantle carbonate fluids p417
Yu. N. Pal'yanov, A. G. Sokol, Yu. M. Borzdov, A. F. Khokhryakov and N. V. Sobolev
doi:10.1038/22678
First paragraph | Full Text | PDF (125K)
Ageing, fitness and neurocognitive function p418
Arthur F. Kramer, Sowon Hahn, Neal J. Cohen, Marie T. Banich, Edward McAuley, Catherine R. Harrison, Julie Chason, Eli Vakil, Lynn Bardell, Richard A. Boileau and Angela Colcombe
doi:10.1038/22682
First paragraph | Full Text | PDF (125K)
Developmental model for thalidomide action p419
Reinhard Neubert, Hans-Joachim Merker and Diether Neubert
doi:10.1038/22685
First paragraph | Full Text | PDF (89K)
reply: Developmental model for thalidomide action p420
Clifford J. Tabin
doi:10.1038/22687
First paragraph | Full Text | PDF (67K)
Book Reviews
Equality in glory and culpability p421
David Joravsky
doi:10.1038/22689
Journey into a strange affliction p422
Mary Robertson
doi:10.1038/22692
Getting at where it hurts p423
John Carmody
doi:10.1038/22695
A provincial setting for the oceans p423
Yves Dandonneau
doi:10.1038/22698
Loose round-up lacks even circular logic p424
Ivor Grattan-Guinness
doi:10.1038/22700
New in paperback p424
doi:10.1038/22702
Article
Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction p425
J. E. T. Corrie, B. D. Brandmeier, R. E. Ferguson, D. R. Trentham, J. Kendrick-Jones, S. C. Hopkins, U. A. van der Heide, Y. E. Goldman, C. Sabido-David, R. E. Dale, S. Criddle and M. Irving
doi:10.1038/22704
Abstract | Full Text | PDF (314K)
Letters to Nature
Discovery of the acoustic Faraday effect in superfluid 3He-B p431
Y. Lee, T. M. Haard, W. P. Halperin and J. A. Sauls
doi:10.1038/22712
First paragraph | Full Text | PDF (159K)
Similarities between the growth dynamics of university research and of competitive economic activities p433
Vasiliki Plerou, Luís A. Nunes Amaral, Parameswaran Gopikrishnan, Martin Meyer and H. Eugene Stanley
doi:10.1038/22719
First paragraph | Full Text | PDF (276K)
Abrupt changes in North American climate during early Holocene times p437
F. S. Hu, D. Slawinski, H. E. Wright, Jr, E. Ito, R. G. Johnson, K. R. Kelts, R. F. McEwan and A. Boedigheimer
doi:10.1038/22728
First paragraph | Full Text | PDF (242K)
Large-scale freshening of intermediate waters in the Pacific and Indian oceans p440
Annie P. S. Wong, Nathaniel L. Bindoff and John A. Church
doi:10.1038/22733
First paragraph | Full Text | PDF (365K)
Rigidity variations with depth along interplate megathrust faults in subduction zones p443
Susan L. Bilek and Thorne Lay
doi:10.1038/22739
First paragraph | Full Text | PDF (25K)
Missing lithotroph identified as new planctomycete p446
Marc Strous, John A. Fuerst, Evelien H. M. Kramer, Susanne Logemann, Gerard Muyzer, Katinka T. van de Pas-Schoonen, Richard Webb, J. Gijs Kuenen and Mike S. M. Jetten
doi:10.1038/22749
First paragraph | Full Text | PDF (367K)
Sperm competition between Drosophila males involves both displacement and incapacitation p449
Catherine S. C. Price, Kelly A. Dyer and Jerry A. Coyne
doi:10.1038/22755
First paragraph | Full Text | PDF (139K)
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide p452
Peter M. Zygmunt, Jesper Petersson, David A. Andersson, Huai-hu Chuang, Morten Sørgård, Vincenzo Di Marzo, David Julius and Edward D. Högestätt
doi:10.1038/22761
First paragraph | Full Text | PDF (531K)
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles p457
Iris Augustin, Christian Rosenmund, Thomas C. Südhof and Nils Brose
doi:10.1038/22768
First paragraph | Full Text | PDF (386K) | Supplementary information
Cohesin Rec8 is required for reductional chromosome segregation at meiosis p461
Yoshinori Watanabe and Paul Nurse
doi:10.1038/22774
First paragraph | Full Text | PDF (281K)
Creation of human tumour cells with defined genetic elements p464
William C. Hahn, Christopher M. Counter, Ante S. Lundberg, Roderick L. Beijersbergen, Mary W. Brooks and Robert A. Weinberg
doi:10.1038/22780
First paragraph | Full Text | PDF (246K)
Essential role for oncogenic Ras in tumour maintenance p468
Lynda Chin, Alice Tam, Jason Pomerantz, Michelle Wong, Jocelyn Holash, Nabeel Bardeesy, Qiong Shen, Ronan O'Hagan, Joe Pantginis, Hao Zhou, James W. Horner, II, Carlos Cordon-Cardo, George D. Yancopoulos and Ronald A. DePinho#
doi:10.1038/22788
First paragraph | Full Text | PDF (472K)
Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor p472
Scott A. Lloyd, Frank G. Whitby, David F. Blair and Christopher P. Hill
doi:10.1038/22794
First paragraph | Full Text | PDF (270K)
Structure of cytochrome c nitrite reductase p476
Oliver Einsle, Albrecht Messerschmidt, Petra Stach, Gleb P. Bourenkov, Hans D. Bartunik, Robert Huber and Peter M. H. Kroneck
doi:10.1038/22802
First paragraph | Full Text | PDF (383K)
Proton translocation by cytochrome c oxidase p480
Michael I. Verkhovsky, Audrius Jasaitis, Marina L. Verkhovskaya, Joel E. Morgan and Mårten Wikström
doi:10.1038/22813
First paragraph | Full Text | PDF (1,271K)
New on the Market
Super models in the laboratory p485
A culling of molecular modelling and other chemistry programs from commercial and.edu sources. Packages vary from the educational to the 'professional', with some with a foot in both camps.
Compiled in the C i t Nature office from information provided by the manufacturers.
doi:10.1038/22818
