Table of contents
Volume 392 Number 6676 pp525-634
Opinion
The complex realities of sharing genetic assets p525
Debates on bioprospecting tend to be dominated by historical distrust and visions of new riches. Companies and countries alike need to recognize each other's needs, but remain realistic about the issues at stake.
doi:10.1038/33204
News
Ex-UN AIDS chief is blasted for remarks on vaccine strategy p527
Meredith Wadman
doi:10.1038/33206
South African drugs agency to be replaced p527
Michael Cherry
doi:10.1038/33209
New Chinese premier takes on the reins of scientific reform p528
David Swinbanks
doi:10.1038/33211
Call to scrap licences for travel to Cuba p529
Colin Macilwain
doi:10.1038/33214
Irish scientists face another budget blow p529
Alison Abbott
doi:10.1038/33217
British scientists in 'last chance' appeal p530
David Dickson and Ehsan Masood
doi:10.1038/33219
NASA critics silenced as Mars loses face p530
Tony Reichhardt
doi:10.1038/33221
Peer review cuts power of Italy's 'barons' p531
Alison Abbott
doi:10.1038/33224
Grants lure young researchers back home p531
Alison Abbott
doi:10.1038/33226
News Analysis
British BSE reckoning tells a dismal tale p532
Evidence heard during the first four weeks of the public inquiry into the British government's handling of the BSE affair points to a catalogue of errors enacted against a background of spending cuts and deregulation.
Declan Butler
doi:10.1038/33228
Political initiatives contributed to crisis p533
Declan Butler
doi:10.1038/33231
Briefings
When rhetoric hits reality in debate on bioprospecting p535
The growing interest of pharmaceutical and agri-business companies in genes from natural products is generating a complex set of conflicts with Third World nations, where most of the world's genetic diversity is to be found.
Colin Macilwain
doi:10.1038/33237
India seeks tighter controls on germplasm p536
K. S. Jayaraman
doi:10.1038/33240
Social equity versus private property: striking the right balance p537
Ehsan Masood
doi:10.1038/33243
Brazil's scientists warn against 'nationalistic' restrictions p538
Ricardo Bonalume Neto
doi:10.1038/33246
A formula for indigenous involvement p539
Ehsan Masood
doi:10.1038/33249
Old scores surface as African states face new opportunities p540
Ehsan Masood
doi:10.1038/33251
Correspondence
Numbers of lab animals questioned p541
Andrew N. Rowan
doi:10.1038/33254
Whither whaling? p541
Mark Simmonds and Christopher Stroud
doi:10.1038/33256
No independence for French researchers p542
Eric Buffetaut
doi:10.1038/33258
Towards European academic union p542
Jesus Martinez-Frias and Jose A. Rodriguez-Losada
doi:10.1038/33260
US teaching methods p542
Madhusudan G. Soni
doi:10.1038/33262
Correction: Funding and research performance p542
doi:10.1038/33264
News and Views
The centenarian Golgi apparatus p543
Paolo Mazzarello and Marina Bentivoglio
doi:10.1038/33266
Human genetics: Putting the Parkin into Parkinson's p544
Robert L. Nussbaum
doi:10.1038/33271
Archaeology: A panorama of ancient Rome p545
Nicholas Purcell
doi:10.1038/33273
Developmental biology: Worlds in common through NF-
B p547
Cheryll Tickle
doi:10.1038/33276
100 and 50 years ago p547
doi:10.1038/33279
Extragalactic astronomy: A ring in truth p548
Stephen Battersby
doi:10.1038/33281
Computing: Parallel thinking p549
C. S. Calude and J. L. Casti
doi:10.1038/33284
Ozone depletion: A greenhouse warming connection p551
Ross J. Salawitch
doi:10.1038/33287
Evolutionary ecology: Different routes to similar ends p552
Paul H. Harvey and Linda Partridge
doi:10.1038/33290
Signal transduction: Taking the Rap p553
Christopher J. Marshall
doi:10.1038/33293
Daedalus: The eye of mercury p554
David Jones
doi:10.1038/33296
Art and Science
Hesse-Honegger's hand-work p555
Cornelia Hesse-Honegger is fascinated by the beauty of bugs. After the Chernobyl disaster she set out with her paintbox on the trail of mutated insects, convinced that they were the result of radiation poisoning.
Martin Kemp
doi:10.1038/33298
Scientific Correspondence
Florida's mystery coral-killer identified p557
Laurie L. Richardson, Walter M. Goldberg, Kevin G. Kuta, Richard B. Aronson, Garriet W. Smith, Kim B. Ritchie, John C. Halas, Joshua S. Feingold and Steven L. Miller
doi:10.1038/33302
First paragraph | Full Text | PDF (243K)
Termites fumigate their nests with naphthalene p558
J. Chen, G. Henderson, C. C. Grimm, S. W. Lloyd and R. A. Laine
doi:10.1038/33305
First paragraph | Full Text | PDF (176K)
Vitamin C exhibits pro-oxidant properties p559
Ian D. Podmore, Helen R. Griffiths, Karl E. Herbert, Nalini Mistry, Pratibha Mistry and Joseph Lunec
doi:10.1038/33308
First paragraph | Full Text | PDF (151K)
Regulatory factor linked to late-onset diabetes? p560
Sanjoy Dutta, Susan Bonner-Weir, Marc Montminy and Christopher Wright
doi:10.1038/33311
First paragraph | Full Text | PDF (361K)
Correction p560
doi:10.1038/33314
Book Reviews
New testament on retroviruses p561
Robin A. Weiss
doi:10.1038/33316
Connoisseur's collection p561
A. Lindsay Greer
doi:10.1038/33318
Reproductive thermodynamics p561
doi:10.1038/33320
Mathematics of the natural world p562
doi:10.1038/33323
Scientific Correspondence
When language doesn't add up p562
Geoffrey K. Pullum
doi:10.1038/33326
Book Reviews
Detecting the undetectable p563
Peter L. Biermann
doi:10.1038/33328
History repeats itself p564
Leslie Sage
doi:10.1038/33331
New in paperback p564
doi:10.1038/33334
Scientific Correspondence
Corrections p564
doi:10.1038/33336
Corrections p564
doi:10.1038/33338
Progress
Chemokines and leukocyte traffic p565
Marco Baggiolini
doi:10.1038/33340
Abstract | Full Text | PDF (296K)
Article
Essential role of mouse telomerase in highly proliferative organs p569
Han-Woong Lee, Maria A. Blasco, Geoffrey J. Gottlieb, James W. Horner, II, Carol W. Greider and Ronald A. DePinho
doi:10.1038/33345
Abstract | Full Text | PDF (532K)
Letters to Nature
Large convection cells as the source of Betelgeuse's extended atmosphere p575
Jeremy Lim, Chris L. Carilli, Stephen M. White, Anthony J. Beasley and Ralph G. Marson
doi:10.1038/33352
First paragraph | Full Text | PDF (410K)
Extreme oxygen-isotope compositions in magnetite from unequilibrated ordinary chondrites p577
Byeon-Gak Choi, Kevin D. McKeegan, Alexander N. Krot and John T. Wasson
doi:10.1038/33356
First paragraph | Full Text | PDF (400K)
Superconductivity at 25.5 K in electron-doped layered hafnium nitride p580
Shoji Yamanaka, Ken-ichi Hotehama and Hitoshi Kawaji
doi:10.1038/33362
First paragraph | Full Text | PDF (316K)
Structures of medium-sized silicon clusters p582
Kai-Ming Ho, Alexandre A. Shvartsburg, Bicai Pan, Zhong-Yi Lu, Cai-Zhuang Wang, Jacob G. Wacker, James L. Fye and Martin F. Jarrold
doi:10.1038/33369
First paragraph | Full Text | PDF (326K)
Interactive effects of ozone depletion and vertical mixing on photosynthesis of Antarctic phytoplankton p585
Patrick J. Neale, Richard F. Davis and John J. Cullen
doi:10.1038/33374
First paragraph | Full Text | PDF (308K)
Increased polar stratospheric ozone losses and delayed eventual recovery owing to increasing greenhouse-gas concentrations p589
Drew T. Shindell, David Rind and Patrick Lonergan
doi:10.1038/33385
First paragraph | Full Text | PDF (348K)
See also: News and Views by Salawitch
Variability of the path of the Kuroshio ocean current over the past 25,000 years p592
Ken Sawada and Nobuhiko Handa
doi:10.1038/33391
First paragraph | Full Text | PDF (302K)
Dissociation of the neural correlates of implicit and explicit memory p595
Michael D. Rugg, Ruth E. Mark, Peter Walla, Astrid M. Schloerscheidt, Claire S. Birch and Kevin Allan
doi:10.1038/33396
First paragraph | Full Text | PDF (328K)
A cortical representation of the local visual environment p598
Russell Epstein and Nancy Kanwisher
doi:10.1038/33402
First paragraph | Full Text | PDF (370K)
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice p601
Christophe Mulle, Andreas Sailer, Isabel Pérez-Otaño, Heather Dickinson-Anson, Pablo E. Castillo, Ingrid Bureau, Cornelia Maron, Fred H. Gage, Jeffrey R. Mann, Bernhard Bettler and Stephen F. Heinemann
doi:10.1038/33408
First paragraph | Full Text | PDF (369K)
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism p605
Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori, Hiroto Matsumine, Yasuhiro Yamamura, Shinsei Minoshima, Masayuki Yokochi, Yoshikuni Mizuno and Nobuyoshi Shimizu
doi:10.1038/33416
First paragraph | Full Text | PDF (335K) | Supplementary information
See also: News and Views by Nussbaum
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells p608
Brian P. Zambrowicz, Glenn A. Friedrich, Eric C. Buxton, Stan L. Lilleberg, Christophe Person and Arthur T. Sands
doi:10.1038/33423
First paragraph | Full Text | PDF (298K) | Supplementary information
Role of Rel/NF-B transcription factors during the outgrowth of the vertebrate limb p611
Yumi Kanegae, Ana Teresa Tavares, Juan Carlos Izpisúa Belmonte and Inder M. Verma
doi:10.1038/33429
First paragraph | Full Text | PDF (462K) | Supplementary information
See also: News and Views by Tickle
Inhibition of NF-B activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis p615
Paul B. Bushdid, Dana M. Brantley, Fiona E. Yull, Gareth L. Blaeuer, Loren H. Hoffman, Lee Niswander and Lawrence D. Kerr
doi:10.1038/33435
First paragraph | Full Text | PDF (818K) | Supplementary information
See also: News and Views by Tickle
A proteolytic system that compensates for loss of proteasome function p618
Rickard Glas, Matthew Bogyo, John S. McMaster, Maria Gaczynska and Hidde L. Ploegh
doi:10.1038/33443
First paragraph | Full Text | PDF (383K)
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor p622
Randall D. York, Hong Yao, Tara Dillon, Cindy L. Ellig, Stephani P. Eckert, Edwin W. McCleskey and Philip J. S. Stork
doi:10.1038/33451
First paragraph | Full Text | PDF (419K)
See also: News Analysis by Butler
The 
2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange p626
Randy A. Hall, Richard T. Premont, Chung-Wai Chow, Jeremy T. Blitzer, Julie A. Pitcher, Audrey Claing, Robert H. Stoffel, Larry S. Barak, Shirish Shenolikar, Edward J. Weinman, Sergio Grinstein and Robert J. Lefkowitz
doi:10.1038/33458
First paragraph | Full Text | PDF (319K)
Correction: Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein p630
Stefan Brocke, Koenraad Gijbels, Mark Allegretta, Iris Ferber, Christopher Piercy, Thomas Blankenstein, Roland Martin, Ursula Utz, Nathan Karin, Dennis Mitchell, Timo Veromaa, Ari Waisman, Amitabh Gaur, Paul Conlon, Nicholas Ling, Paul J. Fairchild, David C. Wraith, Anne O'Garra, C. Garrison Fathman and Lawrence Steinman
doi:10.1038/33465
A new pattern for helix–turn–helix recognition revealed by the PU.1 ETS-domain–DNA complex p630
Ramadurgam Kodandapani, Frédéric Pio, Chao-Zhou Ni, Gennaro Piccialli, Michael Klemsz, Scott McKercher, Richard A. Maki and Kathryn R. Ely
doi:10.1038/33467
New on the Market
Federation special p631
Focusing on experimental biology, a variety of products for image analysis and microscopy are presented, as well as a line of incubators, a Saccharomyces pombe-based protein expression system and new laboratory handware.
compiled by Brendan Horton from information provided by the manufacturers. c b B H f i p b t
doi:10.1038/33469
