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Volume 392 Issue 6676, 9 April 1998

Opinion

  • Debates on bioprospecting tend to be dominated by historical distrust and visions of new riches. Companies and countries alike need to recognize each other's needs, but remain realistic about the issues at stake.

    Opinion

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News

  • cape town

    South Africa is to have a new Medicines Regulatory Authority, replacing the old Medicines Control Council, which clashed with government by blocking trials of a controversial AIDS drug.

    • Michael Cherry
    News
  • washington

    The former director of the World Health Organisation's Global Programme on AIDS has accused the National Institutes of Health of violating human rights by failing to proceed to large scale human efficacy trials of AIDS vaccines.

    • Meredith Wadman
    News
  • washington

    Stringent travel rules are blocking scientific collaboration between the United States and Cuba, according to a report from the American Association for the Advancement of Science.

    • Colin Macilwain
    News
  • munich

    Irish scientists have been told that there is no money for new basic research projects in the 1998 budget of the government's research agency.

    • Alison Abbott
    News
  • london

    The British government is being pressed to include a significant increase in funding for science in its eagerly awaited review of government spending.

    • David Dickson
    • Ehsan Masood
    News
  • washington

    More than 20 years after the'Mars face' picture was taken by the Viking lander, new close-ups captured by the Mars Global Surveyor now reveal that it is just a natural rock formation.

    • Tony Reichhardt
    News
  • milan

    Italy has replaced its controversial system of awarding research grants based on personal contacts to one using independent peer review - much to the chagrin of the country's powerful academic'barons'.

    • Alison Abbott
    News
  • milan

    One of Italy's largest cancer research charities is to offer start-up grants designed to lure back the many talented young scientists working abroad.

    • Alison Abbott
    News
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News Analysis

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News in Brief

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Briefing

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Correspondence

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Correction

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News & Views

  • One hundred years ago, Camillo Golgi described the cellular apparatus that has since become synonymous with his name. Although its existence was questioned for 50 years, this organelle is now established as the cell's centre for the processing and secretion of proteins.

    • Paolo Mazzarello
    • Marina Bentivoglio
    News & Views
  • Parkinson's disease is characterized by parkinsonism — rigidity, resting tremor and slowness in initiating and carrying out movement. The gene for a rare autosomal recessive form of parkinsonism (AR-JP) has now been cloned and, although AR-JP differs in some respects from Parkinson's disease, the new gene could help to shed light on the causes of Parkinson's. Termedparkin, the gene has a ubiquitin homology domain, indicating that a defect in proteasome function could be involved in Parkinson's disease.

    • Robert L. Nussbaum
    News & Views
  • A remarkable wall-painting, probably from the third century AD, was found in the centre of Rome on 4 March. It is an extremely ambitious cityscape. It has not been completely excavated, the painting has not yet been cleaned, and detailed photographs are not yet available. But clearly this one find vastly increases our store of information about Roman visual ideas of urban space, and of public and private architecture.

    • Nicholas Purcell
    News & Views
  • The regulator of gene transcription, NF-κB, was first identified in the B cells of the immune system. A further function for it is emerging through studies of the chick limb, and two new papers show that NF-κB is on the signalling pathway that specifies correct limb development — when its activity is blocked, the result is truncated limbs. This line of research is all the more intriguing because of close parallels with development in the fruitflyDrosophila, and because mutations in one of the signalling targets of NF-κB, a gene called Twist, result in a human condition characterized by limb anomalies.

    • Cheryll Tickle
    News & Views
  • Gravity bends light. That is a prediction of Einstein's theory of general relativity, and observations bear it out — most obviously, in gravitational lenses, where a distant galaxy's image is stretched or multiplied, or both, by an intervening mass. In the latest lens to be discovered, the image forms a complete ring (an Einstein ring') around the lensing galaxy. With a large enough sample of lenses, one can set constraints on the geometry of the Universe.

    • Stephen Battersby
    News & Views
  • Unconventional models of computing were discussed at a meeting in Auckland earlier this year. DNA computers, for example, can be proved to be universal computers by virtue of base-pair complementarity; and there are now several possible schemes for creating quantum computers. More concretely, a thermodynamically reversible computer was demonstrated for the first time.

    • C. S. Calude
    • J. L. Casti
    News & Views
  • Researchers employing a general circulation model have forged a previously unappreciated connection between greenhouse-gas warming and ozone in the lower stratosphere. Their conclusion is tentative but worrisome — that despite reductions in the emissions of ozone-depleting chlorofluorocarbons, levels of ozone over the Arctic will continue to decline until well into the next century. These findings will however be subject to rigorous further testing by both observation and theory.

    • Ross J. Salawitch
    News & Views
  • An illuminating test case of evolutionary theory comes from a new morphological and molecular analysis of lizards on the islands of the Greater Antilles in the Caribbean. The different'ecotypes' of lizard (that is, species adapted to different environments) on the four islands of the Antilles show a remarkable degree of convergent evolution. That in itself is no great surprise. But the authors also have a more novel finding, in that the order of evolution of the various ecomorphs seems to differ among the islands.

    • Paul H. Harvey
    • Linda Partridge
    News & Views
  • Signalling through different growth factors can lead to different outcomes. For example, whereas nerve growth factor (NGF) leads to differentiation of the PC12 cell line, signalling through epidermal growth factor (EGF) does not. How is such specificity achieved? Differentiation occurs because NGF leads to sustained activation of the extracellular-signal-regulated kinases (ERKs), whereas EGF leads to only transient activation of the ERKs. Moreover, the pathway leading to activation of ERKs was thought to hinge on the small GTPase Ras, but one group has now found that the key may be another small GTPase called Rap1.

    • Christopher J. Marshall
    News & Views
  • The mirrors of large telescopes require adaptive optical systems to correct the distortion stemming from atmospheric fluctuations and the flexing of the mirrors under their own weight. Daedalus is now working on a really adaptive, liquid mirror using mercury. His proposal is to employ an array of electrodes set in a large dish of mercury, and a set of coils by which a complex magnetic field can be imposed on the mercury. The result — forces that will produce hydrostatic pressure in the liquid and allow its surface to be shaped to order.

    • David Jones
    News & Views
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Art and Science

  • Cornelia Hesse-Honegger is fascinated by the beauty of bugs. After the Chernobyl disaster she set out with her paintbox on the trail of mutated insects, convinced that they were the result of radiation poisoning.

    • Martin Kemp
    Art and Science
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Scientific Correspondence

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Correction

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Book Review

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Scientific Correspondence

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Book Review

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Correction

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Progress

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Article

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Letter

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Erratum

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Letter

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New on the Market

  • Focusing on experimental biology, a variety of products for image analysis and microscopy are presented, as well as a line of incubators, a Saccharomyces pombe-based protein expression system and new laboratory handware. compiled by Brendan Horton from information provided by the manufacturers. c b B H f i p b t

    New on the Market
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