Opinion

Hubris, benefits and minefields of human cloning p211

One man's absurdities are a gift to witless stereotypers of scientists. They are also an unwelcome stimulus to much needed consideration of the realities and implications of an uncomfortable technology.

doi:10.1038/34480

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News

France eyes role in US mission to retrieve rocks from Mars p213

Tony Reichhardt

doi:10.1038/34482

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French inquiry to look into thesis fraud p213

Eric Glover

doi:10.1038/34486

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Quebec says yes to federal money for infrastructure p214

David Spurgeon

doi:10.1038/34488

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Biodiversity body 'needs more science' p215

Ehsan Masood

doi:10.1038/34491

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South Africa sells research to its children p215

Michael Cherry

doi:10.1038/34494

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Clinton pledges more money for science next year p216

Colin Macilwain

doi:10.1038/34496

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Collapse of charity boosts call for tighter oversight p216

Ehsan Masood

doi:10.1038/34498

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Hubble sheds new light on Saturn's poles p216

doi:10.1038/34500

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Controversial cancer drug wins local approval in Italy p217

Alison Abbott

doi:10.1038/34503

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Fire damages Germany's Einstein tower p217

Alison Abbott

doi:10.1038/34505

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Seed sows further doubts on cloning p218

Plans by a Chicago embryologist to clone a human being have renewed pressure for swift action to ban the practice in the United States. But scientists warn that an ill-drafted law could stifle genuine research.

Meredith Wadman

doi:10.1038/34508

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US ban 'would resist challenges in court' p218

Meredith Wadman

doi:10.1038/34511

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Unesco declaration lacks legal teeth p219

Meredith Wadman and Declan Butler

doi:10.1038/34513

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Europe brings in first international ban p219

Declan Butler

doi:10.1038/34515

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news in brief p220

doi:10.1038/34517

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Correspondence

Impact takes precedence over interest p222

Dirk Schoonbaert and Gilbert Roelants

doi:10.1038/34519

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Challenges for vaccine institute p222

Subhash C. Arya

doi:10.1038/34521

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News and Views

The eyes have it p223

Laurence D. Hurst and Andrew Pomiankowski

doi:10.1038/34523

Full Text | PDF (177K)

Selfish genes and meiotic drive p223

Laurence D. Hurst

doi:10.1038/34526

Full Text | PDF (177K)

Biological oceanography:  Diatoms and the silicate factor p224

Victor Smetacek

doi:10.1038/34528

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Developmental biology:  Hox gene variation and evolution p225

Axel Meyer

doi:10.1038/34530

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100 and 50 years ago p227

doi:10.1038/34533

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Isotope astrophysics:  Two cradles for the heavy elements p228

A. G. W. Cameron

doi:10.1038/34535

Full Text | PDF (269K)

Satellite mapping:  3-D glacial flow p229

John VanDecar

doi:10.1038/34539

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Structural biology:  A mechanism for all polymerases p231

Thomas A. Steitz

doi:10.1038/34542

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Smart materials:  Off and on reflection p232

Philip Ball

doi:10.1038/34547

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Tumour suppressors:  Teaming up to restrain cancer p233

Moshe Oren

doi:10.1038/34551

Full Text | PDF (237K)

Daedalus:  Bacterial diplomacy p234

David Jones

doi:10.1038/34554

Full Text | PDF (155K)

Art and Science

Goldsworthy's genera p235

Andy Goldsworthy sets out to explore some of the recurring forms in the world around us, using a variety of media drawn from nature itself — snow and sand, twigs and thorns.

Martin Kemp

doi:10.1038/34556

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Scientific Correspondence

Mudskippers store air in their burrows p237

Atsushi Ishimatsu, Yasuhiro Hishida, Toru Takita, Takeshi Kanda, Shin Oikawa, Tatsusuke Takeda and Khoo Khay Huat

doi:10.1038/34560

First paragraph | Full Text | PDF (269K)

Efficient pollination of alpine plants p238

Robin A. Bingham and Andrea R. Orthner

doi:10.1038/34564

First paragraph | Full Text | PDF (181K)

How molecular motors work in muscle p239

Andrew Huxley

doi:10.1038/34567

First paragraph | Full Text | PDF (157K)

Reply:  How molecular motors work in muscle p239

Joe Howard

doi:10.1038/34569

First paragraph | Full Text | PDF (157K)

A new classification for HIV-1 p240

E. A. Berger, R. W. Doms, E.-M. Fenyö, B. T. M. Korber, D. R. Littman, J. P. Moore, Q. J. Sattentau, H. Schuitemaker, J. Sodroski and R. A. Weiss

doi:10.1038/34571

First paragraph | Full Text | PDF (148K)

Book Reviews

The history of healing laid bare p241

Alfred W. Crosby

doi:10.1038/34573

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Industrial revolutions p242

David E. Nye

doi:10.1038/34576

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At the sharp end p243

John A. J. Gowlett

doi:10.1038/34579

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Technological heaven p244

Howard P. Segal

doi:10.1038/34582

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hypothesis

Constraints on cortical and thalamic projections: the no-strong-loops hypothesis p245

Francis Crick and Christof Koch

doi:10.1038/34584

Abstract | Full Text | PDF (272K)

Article

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution p251

Sylvie Doublié, Stanley Tabor, Alexander M. Long, Charles C. Richardson and Tom Ellenberger

doi:10.1038/34593

Abstract | Full Text | PDF (672K)

See also: News and Views by Steitz

Letters to Nature

The interstellar chemistry of PAH cations p259

Theodore P. Snow, Valery Le Page, Yeghis Keheyan and Veronica M. Bierbaum

doi:10.1038/34602

First paragraph | Full Text | PDF (203K)

Tellurium in pre-solar diamonds as an indicator for rapid separation of supernova ejecta p261

S. Richter, U. Ott and F. Begemann

doi:10.1038/34605

First paragraph | Full Text | PDF (244K)

See also: News and Views by Cameron

Quantum interference in electron collision p263

R. C. Liu, B. Odom, Y. Yamamoto and S. Tarucha

doi:10.1038/34611

First paragraph | Full Text | PDF (303K)

Picosecond discharges and stick–slip friction at a moving meniscus of mercury on glass p266

R. Budakian, K. Weninger, R. A. Hiller and S. J. Putterman

doi:10.1038/34617

First paragraph | Full Text | PDF (284K)

The structure of a new phase of ice p268

C. Lobban, J. L. Finney and W. F. Kuhs

doi:10.1038/34622

First paragraph | Full Text | PDF (355K)

Silicate regulation of new production in the equatorial Pacific upwelling p270

Richard C. Dugdale and Frances P. Wilkerson

doi:10.1038/34630

First paragraph | Full Text | PDF (378K)

See also: News and Views by Smetacek

Three-dimensional glacial flow and surface elevation measured with radar interferometry p273

Johan J. Mohr, Niels Reeh and Søren N. Madsen

doi:10.1038/34635

First paragraph | Full Text | PDF (410K)

See also: News and Views by VanDecar

Male eye span in stalk-eyed flies indicates genetic quality by meiotic drive suppression p276

Gerald S. Wilkinson, Daven C. Presgraves and Lili Crymes

doi:10.1038/34640

First paragraph | Full Text | PDF (312K)

See also: News and Views by Hurst & Pomiankowski

Spontaneous sign systems created by deaf children in two cultures p279

Susan Goldin-Meadow and Carolyn Mylander

doi:10.1038/34646

First paragraph | Full Text | PDF (220K)

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes p281

Paola Bezzi, Giorgio Carmignoto, Lucia Pasti, Sabino Vesce, Daniela Rossi, Barbara Lodi Rizzini, Tullio Pozzan and Andrea Volterra

doi:10.1038/34651

First paragraph | Full Text | PDF (352K)

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway p285

Carla Boccaccio, Margherita Andò, Luca Tamagnone, Alberto Bardelli, Paolo Michieli, Carlo Battistini and Paolo M. Comoglio

doi:10.1038/34657

First paragraph | Full Text | PDF (341K)

DNA shuffling of a family of genes from diverse species accelerates directed evolution p288

Andreas Crameri, Sun-Ai Raillard, Ericka Bermudez and Willem P. C. Stemmer

doi:10.1038/34663

First paragraph | Full Text | PDF (478K)

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene p291

Hendrik W. van Veen, Richard Callaghan, Loredana Soceneantu, Alessandro Sardini, Wil N. Konings and Christopher F. Higgins

doi:10.1038/34669

First paragraph | Full Text | PDF (389K)

The candidate tumour suppressor p33^ING1cooperates with p53 in cell growth control p295

Igor Garkavtsev, Irina A. Grigorian, Valeria S. Ossovskaya, Mikhail V. Chernov, Peter M. Chumakov and Andrei V. Gudkov

doi:10.1038/34675

First paragraph | Full Text | PDF (323K)

See also: News and Views by Oren

MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes p298

Timothy J. Hemesath, E. Roydon Price, Clifford Takemoto, Tina Badalian and David E. Fisher

doi:10.1038/34681

First paragraph | Full Text | PDF (338K)

Engineering cyclophilin into a proline-specific endopeptidase p301

Eric Quéméneur, Mireille Moutiez, Jean-Baptiste Charbonnier and Andr Ménez

doi:10.1038/34687

First paragraph | Full Text | PDF (477K)

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal p304

James R. Kiefer, Chen Mao, Jeffrey C. Braman and Lorena S. Beese

doi:10.1038/34693

First paragraph | Full Text | PDF (526K)

See also: News and Views by Steitz

Erratum:  Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures p307

Pamela J. Skinner, Beena T. Koshy, Christopher J. Cummings, Ivan A. Klement, Kara Helin, Antonio Servadio, Huda Y. Zoghbi and Harry T. Orr

doi:10.1038/34701

Full Text | PDF (1,241K)