Abstract
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
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Emsley, J., White, H., O'Hara, B. et al. Structure of pentameric human serum amyloid P component. Nature 367, 338–345 (1994). https://doi.org/10.1038/367338a0
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DOI: https://doi.org/10.1038/367338a0
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