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Article
Nature 347, 146 - 151 (13 September 1990); doi:10.1038/347146a0

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

Pierre Sokoloff*, Bruno Giros*, Marie-Pascale Martres*, Marie-Louise Bouthenet  & Jean-Charles Schwartz*

*Unité de Neurobiologie et Pharmacologie (U. 109) de I'lNSERM, Centre Paul Broca, 2ter rue d'Alésia, 75014 Paris, France
Laboratoire de Physiologic, Faculté de Pharmacie, Université René Descartes, Paris, France

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

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