Nature 315, 550 - 554 (13 June 1985); doi:10.1038/315550a0

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

Emma Shtivelman, Batia Lifshitz, Robert P. Gale^* & Eli Canaani

Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
^*Department of Medicine (Hematology and Oncology), UCLA School of Medicine, Los Angeles, California 90024, USA

Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.

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