Abstract
THE mouse mutant nude displays thymic aplasia which entails a defect in cell-mediated immune responses. This immune deficiency has been demonstrated by transplantation of normal allogeneic skin and heterogeneic skin from mammalian donors including man, and from avian and reptilian donors1. The nude mutant also accepts transplants of many human malignant tumours, including adenocarcinoma of the colon and rectum, malignant melanoma, squamous cell carcinoma and Burkitt's lymphoma (refs 2–4 and C. O. P., unpublished results). We report here the results of experiments involving transplantation of human foetal organs to the nude mouse.
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References
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POVLSEN, C., SKAKKEBAEK, N., RYGAARD, J. et al. Heterotransplantation of human foetal organs to the mouse mutant nude. Nature 248, 247–249 (1974). https://doi.org/10.1038/248247a0
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DOI: https://doi.org/10.1038/248247a0
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